ANALYSIS OF RISK FACTORS OF ACUTE KIDNEY INJURY IN FULL-TERM NEONATES.
DOI:
https://doi.org/10.11603/24116-4944.2016.1.5974Keywords:
аcute kidney injury, full-term neonates, perinatal pathology, risk factors, odds ratio, confidence interval.Abstract
The associations between probable risk factors and formation of acute kidney injury (AKI) in critically sick full-term neonates have been studied considering health status peculiarities of mothers, the course of antenatal period of development and the period of labor as well as clinical manifestations of the perinatal pathology. A comprehensive clinical-paraclinical examination of 65 full-term neonates have been conducted. Disorders of functional kidney condition have been found in 35 infants against perinatal pathology (I group), and AKI has been diagnosed against severe forms of perinatal pathology in 30 infants (II group). Statistically significant prenatal risk factors of AKI formation in full-term infants have been found to be those connected with pathology of the maternal urinary system (OR 2.68; 95 % CI 1.080–6.680) and complicated obstetrical anamnesis (OR 2.76; 95 % CI 1.129–6.764). The development of AKI in infants with severe perinatal pathology is statistically significant connected with the evaluation by Apgar score no less than 3 at the end of the fifth minute of life (OR 5.08; 95 % CI 1.215–21.263) and clinical signs of multisystem injuries of the body: positive symptom of «a white spot» (OR 7.78; 95 % CI 2.946–20.537). arterial hypotension syndrome (OR 4.19; 95 % CI 1.67–10.516). convulsive syndrome (OR 5.52; 95 % CI 1.891–16.132). hemorrhagic syndrome (OR 5.14; 95 % CI 1.548–17.09) and dietary intolerance (OR 3.42; 95 % CI 1.347–8.497).The clinical signs connected with a high probability of AKI formation and those which lead considerable changes of biochemical markers are: gain of the body weight ≥5 % from the initial one on the second day of life (OR 8.68; CI 1.675–44.912) and swelling syndrome (OR 3.55; 95 % CI 1.174–10.740).
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