THE ANALYSIS OF THE EFFECTIVENESS OF PRENATAL DIAGNOSIS IN FAMILIES WITH REPRODUCTIVE LOSSES IN ANAMNESIS
DOI:
https://doi.org/10.11603/24116-4944.2014.2.5867Keywords:
prenatal diagnosis of congenital malformations, chromosomal abnormalities.Abstract
The aim was to study the effectiveness of prenatal diagnosis in families with a history of reproductive losses . We examined 50 pregnant women at risk of chromosomal disease: genetic counseling pregnant, prenatal fetal research, invasive prenatal diagnosis. Complex examination of 50 families found that the clinical course of pregnancy in women with a history of reproductive losses accompanied by a high level of miscarriage (13.0%), preterm delivery (13.8%), and intrauterine growth retardation (IUGR) (28.7%) due to placental insufficiency (60.0 %). In 21 cases (42.4%) diagnosed with IUGR in women with children born with a chromosomal abnormality in history; 15 (30.5%) of them revealed abnormal karyotypes (balanced) one of the spouses, which can be interpreted as a possible etiology of IUGR . We examined 21 families who underwent ultrasound and found carriage of chromosomal rearrangements in one of the spouses in 15 (71%). After invasive prenatal diagnosis in 18 of 21 families were born healthy children (85%). In two cases, as a result of invasive prenatal diagnosis revealed a balanced translocation and healthy children were born. The proposed forecasting techniques using different methods of prenatal diagnosis (biochemical screening I and II trimesters and invasive prenatal diagnosis by prescription) provide an opportunity to preventthe occurrence of a high probability of loss of reproductive and perinatal pathology.
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