OPTIMIZATION OF THE METHODS FOR PRENATAL DIAGNOSIS OF RH-CONFLICT
DOI:
https://doi.org/10.11603/24116-4944.2014.2.5866Keywords:
pregnancy, haemolytic disease, Rh sensitization, amniocentesis, rhezus factor.Abstract
Studing new approaches of managing pregnants with immunological-conflict diseases remains actual issue. Prenatal diagnostic of hemolitic disease is the most difficult. It requires confirmation of the fact of the disease, level of sensitization and degree of mother's antibodies impact on fetus. High anti-Rh antibody titer shows only probability of fetus damage and development of haemolytic disease of newborn. We studied 120 pregnant women with Rh sensitization. We performed amniocentesis in 31 cases from 16 to 37 weeks of pregnancy for determination of rhezus factor of fetus. 5 of those patients had Rh-negative blood type. In 26 cases pregnantwere diagnosed by Rh sensitization from 1:2 to 1:512 titer, but had no ultrasound features of Rhconflict. In 21 cases fetus Rh-positive factor were determined, meanwhile 5 (23,8%) patients had Rh-negative fetus blood type with anti-Rh antibody titer from 1:64to 1:512. It helped of avoiding of stimulation of preterm delivery and it redused duration of stay in hospital. Pregnants with Rh-positive fetus blood type and had Rh-sensitization remained in hospital under doctor's control and were undergoing dynamic measurement of Rh-antibodies titer in the blood, ultrasound examination. The results were verified after delivery.
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