CONTENTS OF ANTlMlCROBlAL PEPTlDES AND CELLULAR COMPOSlTlON OF OROPHARYNGEAL SECRETlONS lN CHlLDREN WlTH RECURRENT RESPlRATORY TRACT DlSEASES.
DOI:
https://doi.org/10.11603/24116-4944.2014.2.4838Keywords:
children, respiratory diseases, antimicrobial peptides, cellular composition oropharyngeal secretions, atopic dermatitis.Abstract
ln the work determination of antimicrobial peptides and cellular composition of oropharyngeal secretions (OS) from 37 children with recurrent respiratory tract infections (RRTl). Of these, 20 patients with RRTl, 17 - with RRTl and atopic dermatitis (AD). The control group consisted of 10 children who suffered from acute respiratory infections than 4 times a year. ln (OS) was determined the content of defensins в 1-3, lysozyme, lactoferrin, secretory immunoglobulin A (slgA), epithelial cells, neutrophils, lymphocytes. lt was established that the level of defensins в 1- 3 in OS in control group children was 4,04 ± 0,6 mg/ml. At the level of defensins в1- 3 in children with RRTl tended to decrease and reached 3,05 ±0,04 g/ml. ln children with RRTl and AD reported significant reduction of defensin в1- 3 in OS (p <0,01) - 1,58 ±0,2 mg/ml compared with the control group. Under children with RRTl 4-7 years local content protection factors had no significant changes. ln children with RRTl only 8-12 years a statistically significant decrease in slgA - 0,14 ±0,05 g/l compared with the corresponding figure in the control group - 0,43 ±0,17 g/l. Under children with RRTl and AD (4-7 years) tended to decrease the content of all investigated protective factors in the OS significantly the levels of defensins в1-3 and lactoferrin. Underchildren with RRTl and AD 8-12 years registered high levels of lactoferrin and slgA. At children with RRTl and atopic dermatitis (4-7 years) observed the highest content of lymphocytes and decreasing trends of epithelial cells.
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