INFLUENCE of С-511Т POLYMORPHISM Of The INTERLEUKIN 1 р GENE On PTODUCTION of INTERLEUKIN 1 р of CHILDREN WITH FREQUENT RECURRENCE of RESPIRATORY INFECTION.
DOI:
https://doi.org/10.11603/24116-4944.2014.2.4831Keywords:
genetic polymorphism, interleukin 1 р, recurrence of respiratory infection.Abstract
An analysis of the influence of C-511T single nucleotide polymorphism of the interleukin 1 р gene on production of interleukin 1 р was carried out in 80 children with frequent recurrence of respiratory infection and 35 healthy children. The association of the mutant T-allele of the C-511T single nucleotide polymorphism of the interleukin 1р gene and increase of production of interleukin 1р was found. Dominant genotype in healthy children was heterozygous CT-option C-511T polymorphism of IL-1 р (62,86%), while in children with frequent and prolonged episodes of respiratory infections was dominated by CC homozygous genotype of this polymorphism (51.25 %).
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