METHODS ТО IMPROVE OVARIAN RESPONSE WHILE REDUCING THE INDICATORS OF OVARIAN RESERVE.
DOI:
https://doi.org/10.11603/24116-4944.2015.2.4822Keywords:
infertility, oxidative stress, melatonin, 8-isoprostan, ovarian stimulation, in vitro fertilization, IVF.Abstract
There was studied the content of melatonin and 8-izoprostan in serum and follicular fluid on the background of ovarian stimulation in 66 patients who suffer from infertility, who were divided into 2 equal groups. The control group comprised 33 healthy women of reproductive age. It was found that melatonin has a strong antioxidant effect, thereby increasing the number of oocytes obtained in poor responders and 8-isoprostan a reliable indicator of oxidative stress and antioxidant system in blood serum and follicular fluid. The use of antagonists and agonists of gonadotropin releasing hormone for the purpose of inducing superovulation leads to increased oxidative stress processes in follicular fluid.
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