CYTOPROTECTIVE THERAPY IN PATHOLOGY OF UPPER GASTROINTESTINAL TRACT IN CHILDREN WITH BRONCHIAL ASTHMA.
DOI:
https://doi.org/10.11603/24116-4944.2015.2.4746Keywords:
children, bronchial asthma, pathology of upper part of gastrointestinal tract, sucralfate.Abstract
The article presents the results of a study of clinical and immunological efficiency of суЬэргс^есШе therapy with sucralfate in children with bronchial asthma (BA) and concomitant pathology of upper part of gastrointestinal tract (UPGIT). 78 children suffering BA and concomitant pathology of UPGIT were observed. Randomization was performed with method of pairs-copies in 2 groups: I group is 39 children who received sucralfate during 2nd week of treatment for 28 days, in addition to standard therapy of the pathology of UPGIT, conducted according to current protocol (order of Ministry of Health of Ukraine № 438 from 26.05.2010). II group is 39 children who underwent standard therapy only. The group of comparison included 42 children with BA without pathology of UPGIT. Clinical efficiency was estimated on the bases of clinical dynamics, duration of remission of pathology of UPGIT, asthma control during following 12 months after treatment, immunological - on the dynamics of serum levels of IFN-y, IL-4, IL-5, IL-13 before and after treatment. ВА in children with pathology of UPGIT had more severe course and worse control. increased level serum levels of IFN-y, IL-4, IL-5, IL-13 was found as compared to children with BA without pathology of UPGIT. Addition of cytoprotective therapy with sucralfate to complex treatment of pathology of UPGIT in children with BA leads to prolongation of remission of UDGIT pathology, improvement of asthma control, decrease serum levels of proinflammatory cytokines.
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