THE LEVEL OF ENDOGENOUS INTOXICATION IN EXPERIMENTS ON DIFFERENT DOSES OF METHOTREXATE AND PROTECTIVE ACTION OF CALCIUM FOLINATE.
DOI:
https://doi.org/10.11603/24116-4944.2015.1.4723Keywords:
methotrexate, endogenous intoxication index, calcium folio.Abstract
We have studied the index of endogenous intoxication in rats in 54 researches during single and double use methotrexate at a dose of 1 mg/kg for 3 and 7 days. We have explored the protective effect of calcium folio (dose 0.1 mg/kg), at 24 h after injection of methotrexate. One-time use of methotrexate leads to a significant increase of the level of toxicity in rat plasma. Two-time use of methotrexate intoxication make erythrocytic index worse. Using of calcium folio improves index endogenous intoxication and does not depends on a single or double entry cytostatics.
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