DYNAMIC CONDITION OF ANTIGEN-PRESENTING CELLS IN EXTERNAL GENITAL ENDOMETRIOSIS.
DOI:
https://doi.org/10.11603/24116-4944.2015.1.4715Keywords:
women's infertility, endometriosis, endosurgery, immunotherapy.Abstract
The results of observations of 120 infertile patients with external endometriosis are presented in the article. Age of the examined patients was from 21 to 35 years. The most frequent among the clinical manifectations of the disease were: chronic pelvic pain in 83 (69.2 %) patients, algodismenorrhea in 59 (49.2 %), dyspareunia in 46 (38.3 %). Endometriosis of the first and second stage was more frequent - 37 (30.8 %) and 41 (34.2 %) cases accordingly in diagnostic laparoscopy. Adhesions of varying severity were identified in the abdominal cavity in the majority of the patients (61 %). Decreased activity of nature dendritic cells (to 5.2±0.5 kl./mm2 CD23) in the functional layer of the endometrium and (6.0±0.5 kl./mm2 CD23) in the basal layer and increasing of the activity of immature dendritic cells in the basal layer of the endometrium (CD1a kl./mm2 21.2 to 34.2) were found during immunogostochemical study. The foregoing demonstrates a functional suppresion of local immunity and may be a factor that reduces the reproductive function which in turn requires an immunomodulation.
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