NEW PERSPECTIVES ON MECHANISMS OF PATHOGENESIS OF UTERINE LEIOMYOMA.
DOI:
https://doi.org/10.11603/24116-4944.2015.1.4711Keywords:
uterine leiomyoma, immunohistochemical study, pathogenesis.Abstract
Etiology and pathogenesis of uterine leiomyoma - very common female benign tumor are still not very clear. Taking into account the great role of local endocrine regulation of leiomyoma growth, we proposed possible involvement of morphologically normal myometrium in leiomyoma pathogenesis. Based on the proven fact of unfavorable influence of multiple myoma on recurrence rate we conducted a comparative analysis of the expression of immunohistochemical markers in unchanged myometrium of women with uterine leiomyomas. According to data obtained it was possible to distinguish two different types of normal myometrium in women with uterine fibroids. Women with multiple myoma had statistically significant increase of expression of aromatase, TSP-1, VEGF and increased vascular density (CD34).
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