ANALYSIS OF CHANGES IN CELLULAR AND HUMORAL IMMUNE SYSTEM IN WOMEN WITH GENITAL VIRAL INFECTION UNDER THE INFLUENCE OF COMPLEX TREATMENT.

Authors

  • I. V. Kravchuk

DOI:

https://doi.org/10.11603/24116-4944.2015.1.4703

Keywords:

genital viral infection, cellular and humoral immunity, treatment, Kagocel, ozone therapy.

Abstract

Viral infection of the genital tract in women of reproductive age leads to background and precancerous cervical diseases and accompanied by the development of immunopathological reactions. An examination of 100 patients of reproductive age with genital viral infection was found credible general immunity disorders that manifestated changes its humoral with higher levels of Ig G, Ig M and Ig A and cell imbalance by reducing the level of T-helper cells and natural killer cells and a significant increase the number of T-suppressors. To analyze changes in the above parameters of the immune system in patients administered a comprehensive treatment of genital viral infection using antiviral immunomodulator Kagocel and ozone therapy. After treatment was diagnosed normalization of humoral and cellular immune response units total in all patients treated with the proposed method as opposed to conventional therapy. High efficiency appointment Kagocel and ozone therapy in the treatment of genital viral infection in women of reproductive age was proven.

References

Apolykhyna Y. A. Papyllomavyrusnaya ynfektsyya henytalyy: aktualʹnaya problema sovremennoy hynekolohyy y puty ee reshenyya / Y. A. Apolykhyna, E. D. Denysova // Voprosy pedyatryy, akusherstva y hynekolohyy. - 2007. - № 6. - S. 70-75.

Zaporozhan V. M. Stan imunnoyi systemy u zhinok z papilomavirusnoyu infektsiyeyu vysokoho onkohennoho ryzyku / V. M. Zaporozhan, N. M. Rozhkovsʹka, O. V. Shevchuk // Onkolohyya. - 2003. - T. 5, № 2. - S. 125-126.

Khmilʹ S. V. Stan systemnoho imunitetu pry papilomavirusniy infektsiyi ta korektsiya yoho za dopomohoyu kompleksnoyi terapiyi / S. V. Khmilʹ, L. R. Fedoreyko // Visnyk naukovykh doslidzhenʹ. - 2005. - № 1. -S. 47-48.

Zastosuvannya ozonoterapiyi v akusherstvi i hinekolohiyi (metodychni rekomendatsiyi) / Ministerstvo okhorony zdorov'ya Ukrayiny, Ukrayinsʹkyy tsentr naukovoyi medychnoyi informatsiyi ta patentno-litsenziynoyi roboty.- K., 2005. - 39 s.

Pat. 28999 Ukrayina, MPK A 61 R 31/00. Sposib likuvannya patolohiyi shyyky matky, asotsiyovanoyi z papilomavirusnoyu infektsiyeyu / Kravchuk I. V., Drinʹ T. M.; zayavl. 27.09.07 ; opubl. 25.12.07, Byul. № 21.

Human papillomavirus, human immunodeficiency virus and immunosupression / L. A. Denny, S. Franceschi, S. de Saniose [et al.] // Vaccine. - 2012. - № 5. - R. 168-174.

Onda T. Characterization of Ig A response among women with incident HPV 16 infection / T. Onda, J. Carter, L. Koutsky // Virology. - 2003. - Vol. 312, № 1. - P. 213-221.

Vyznachennya stanu pokaznykiv klitynnoho imunitetu pry papilomavirusniy infektsiyi statevykh orhaniv zhinok / V. P. Lakatosh, L. M. Lazarenko, M. YA. Spyvak [ta in.] // Likarsʹka sprava. - 1999. - № 4. - S. 98-102.

Luxton J. Human papillomavirus antigens and Tcell recognition / J. Luxton, P. Shepherd // Curr. Opin. Infect. Dis. - 2001. - Vol. 14, № 2. - P. 139-143.

Dysbalans ymmunorehulyatornykh Th1- y Th2- tsytokynov pry persystentnykh vyrusnykh ynfektsyyakh / Y. O. Naslednykova, N. V. Ryazantseva, V. V. Novytskyy [y dr.] // Medytsynskaya ymmunolohyya. - 2007. - T. 9, № 1. - S. 53-60.

Published

2015-07-17

How to Cite

Kravchuk, I. V. (2015). ANALYSIS OF CHANGES IN CELLULAR AND HUMORAL IMMUNE SYSTEM IN WOMEN WITH GENITAL VIRAL INFECTION UNDER THE INFLUENCE OF COMPLEX TREATMENT. Actual Problems of Pediatrics, Obstetrics and Gynecology, (1). https://doi.org/10.11603/24116-4944.2015.1.4703

Issue

Section

OBSTETRICS AND GYNECOLOGY