EFFECT OF GENE POLYMORPHI3M FAMILY GLUTATHIONE-3-TRAN3FERA3E3 IN THE DEVELOPMENT AND MORBIDITY OF PREMATURE INFANT3 WITH BRONCHOPULMONARY DY3PLA3IA.
DOI:
https://doi.org/10.11603/24116-4944.2015.1.4678Keywords:
bronchopulmonary dysplasia, psychoemotional development, morbidity, GSTT1, GSTM1, GSTR1 genes.Abstract
The purpose of the present paper was to study the morbidity and development of premature infants with BPD in the first two years of life and to identify risk factors including G3T genespolymorphisms that are significantly associated with the negative outcomes of BPD. A cohort prospective study included 33 children with BPD who were discharged from Poltava children hospitals during 2010-2013. Their psychoemotional and statokinetic development in 6,12,18 and 24 months of life were studied. Incidence of acute respiratory viral infections, bronchitis and pneumonia in the same ages was reviewed. The rate of detection of polymorphism G3TT1, G3TM1 and G3TR1 genes was studied. Multiple logistic regression analysis was conducted in order to study the relationship between certain independent variables, clinical and genetic factors. Deletion of glutathione-3-transferas polymorphism is not associated with statokinetic and psychoemotional development of children with BPD and with increased rate of acute infectious respiratory diseases during the first two years of life. Psychoemotional development of childrenwith BPD was significantly associated with the duration of mechanical ventilation (OR 1.269; 95 % CI 1.01-1.603, p=0.045) and not associated with other factors (birth weight, gestational age, providing calories after 28 days of life, providing protein at 28 days of life, male). There was no significant effect of clinical and genetic factors on the development of premature infants with BPD and rate of acute infectious respiratory diseases. Further studies on larger cohort of patients are needed to find clinical and genetic factors that influence on adverse developmental and clinical outcomes in children with BPD.
References
Outcomes of extremely low birth weight infants with bronchopulmonary dysplasia: impact of the physiologic definition / G. Natarajan, A. Pappas, S. Shankaran [et al.] // Early Hum. Dev. - 2012. - Vol. 88, №7. - P. 509-515.
Bronchopulmonary dysplasia predicts adverse developmental and clinical outcomes in very-lowbirthweight infants / S. F. Jeng, C. H. Hsu, P. N. Tsao [et al.] // Dev. Med. Child. Neurol. - 2008. - Vol. 50, №1. - P. 51-57.
Woynarowska M. Risk factors, frequency and severity of bronchopulmonary dysplasia (BPD) diagnosed according to the new disease definition in preterm neonates / M. Woynarowska, M. Rutkowska, K. Szamotulska //Med. Wieku Rozwoj. - 2008. - Vol. 12. - P. 933-941.
Asotsiatsiyi mizh bronkholehenevoyu dysplaziyeyu ta pozytyvnoyu kulʹturoyu krovi u peredchasno narodzhenykh ditey uprodovzh neonatalʹnoho periodu / Kova-lʹova O. M., Horovenko N. H., Chernyavsʹka YU. I., Honcharova YU. O. // Aktualʹni problemy suchasnoyi medytsyny. - 2014. - T.14, № 1 (45). - S. 68-71.
Hayes J. D. Glutathione-S-transferase polymorphisms and their biological consequences / J. D. Hayes, R. C. Strange // Pharmacology. - 2000. - Vol. 61. - R. 154-166.
Otsenka vlyyanyya faktorov ryska polymorfyzma GST-henov na razvytye bronkholehochnoy dysplazyy u prezhdevremenno rozhdennykh detey / Kovaleva E. M., Horovenko N. H., Pokhylʹko V. Y. [y dr.] //GMN: Medytsynskye hruzynskye novosty. - 2014. -№ 9 (234). - S. 105-112.
Klinichnyy protokol medychnoho dohlyadu za zdorovoyu dytynoyu vikom do 3 rokiv : nakaz MOZ Ukrayiny № 149 vid 20.03.2008 r. // Ofitsiynyy visnyk Ukrayiny.- 2008. - 67 s.
A Multiplex Polymerase Chain Reaction Protocol for the Simultaneous Analysis of the Glutathione S-Transferase GSTM1 and GSTT1 Polymorphisms / M. Arand, R. Muhlbauer, J. Hengstler [et al.] // Analytical Biochemistry. - 1996. - № 236. - P.184-186.
Kovalʹova O. M. Doslidzhennya asotsiatsiyi polimorfizmu heniv simeystva hlutation^-transferaz: GSTM1, GSTT1, GSTP1 z rozvytkom bronkholehenevoyi dysplaziyi ta potreboyu v respiratorniy pidtrymtsi / O. M. Kovalʹova, V. I. Pokhylʹko, YU. O. Honcharova // Neonatolohiya, khirurhiya ta perynatalʹna medytsyna. - 2014. - T. 4,№ 2 (12). - S. 50-57.
Bhandari A. Pulmonary outcomes in bronchopulmonary dysplasia / A. Bhandari, H. B. Panitch //Semin. Perinatol. - 2006. - Vol. 30. - P. 219-226.
Wu Weidong. Role of GSTM1 in Resistance to Lung Inflammation / Weidong Wu, David Peden, David Diaz-Sanchez// Free Radic. Biol. Med. -2012. -Vol. 53, №4.- P. 721-729.
Vyznachennya henetychnoyi determinanty u rozvytku perynatalʹnoyi asfiksiyi novonarodzhenykh / N. H. Horovenko, T. K. Znamensʹka, V. I. Pokhylʹko [ta in.] // Perynatolohyya y pedyatryya. - 2009. -№ 4 (40). - S. 37-40.
Saadat M. Genetic polymorphism of glutathione S-transferase T1, M1 and asthma, a meta-analysis of the literature / M. Saadat, M. Ansari-Lari // Pak. J. Biol. Sci.- 2007. - Vol. 10, № 23. - P. 4183-4189.
Glutathione-S-transferase GSTP1 , GSTM1, exercise, ozone and asthma incidence in school children / T. Islam, K. Berhane, R. McConnell [et al.] // Thorax.- 2009. - Vol. 64, № 3. - P. 197-202.
Downloads
Published
How to Cite
Issue
Section
License
Authors who publish in this journal agree to the following terms:
1. The authors reserve the right to authorship of the work and pass the journal right of first publication of this work is licensed under a Creative Commons Attribution License, which allows others to freely distribute the work published with reference to the authors of the original work and the first publication of this magazine.
2. Authors are entitled to enter into a separate agreement on additional non-exclusive distribution of work in the form in which it was published in the magazine (eg work place in the electronic repository institution or publish monographs in part), provided that the reference to the first publication of this magazine.
3. Policy magazine allows and encourages authors placement on the Internet (eg, in storage facilities or on personal websites) manuscript of how to submit the manuscript to the editor and during his editorial processing, since it contributes to productive scientific discussion and positive impact on the efficiency and dynamics of citing published work (see. The Effect of Open Access).
