LIVER TRANSPLANTATION IN A CHILD DUE TO BILIARY ATRESIA: A CLINICAL CASE

Authors

DOI:

https://doi.org/10.11603/24116-4944.2025.2.15824

Keywords:

biliary atresia, Kasai procedure, liver transplantation, children, clinical case

Abstract

Biliary atresia is a rare but life-threatening congenital malformation of the hepatobiliary system, characterized by progressive obliterative process of the bile ducts with the development of cholestasis, biliary cirrhosis and liver failure. A clinical case of a 14-year-old boy with biliary atresia is presented, who underwent Kasai – Tanaki surgery at the age of 2 months, and orthotopic liver transplantation from a cadaveric donor at the age of 1 year and 3 months due to progressive liver failure. The postoperative period was complicated by numerous relaparotomies, recurrent peritonitis, sepsis, and prolonged respiratory therapy. The patient's condition subsequently stabilized. The case highlights the importance of early diagnosis, timely surgical intervention, multidisciplinary management, and individualized immunosuppressive therapy for long-term survival of children after liver transplantation.

Author Biographies

L. V. Besh, Danylo Halytsky Lviv National Medical University

Doctor of Medical Sciences, Professor, Head of the Department Department of Pediatrics №2

O. I. Matsyura, Danylo Halytsky Lviv National Medical University

Doctor of Medical Sciences, Professor Department of Pediatrics № 2

Z. L. Slyuzar, Danylo Halytsky Lviv National Medical University

Department of Pediatrics № 2

D. S. Lyalyuk, Danylo Halytsky Lviv National Medical University

Student

References

Antala, S., & Taylor, S. A. (2022). Biliary atresia in children: Update on disease mechanism, therapies, and patient outcomes. Clinics in Liver Disease, 26(3), 341-354. DOI: https://doi.org/10.1016/j.cld.2022.03.001

Asma, I., & Ahmad, T. (2023). Biliary atresia. In StatPearls [Internet]. StatPearls Publishing.

Baruah, R.R., Bhatnagar, V., Agarwala, S., & Gupta, S.D. (2015). Correlation of pre- and post-operative liver function, duct diameter at porta hepatis, and portal fibrosis with surgical outcomes in biliary atresia. Journal of Indian Association of Pediatric Surgeons, 20(4), 184-188. DOI: https://doi.org/10.4103/0971-9261.161040

Bezerra, J.A., Spino, C., Magee, J.C., Shneider, B.L., Rosenthal, P., Wang, K.S., Erlichman, J., Haber, B.,

Hertel, P.M., Karpen, S.J., Kerkar, N., Loomes, K.M., Molleston, J.P., Murray, K.F., Romero, R., Schwarz, K.B., Shepherd, R., Suchy, F.J., Turmelle, Y.P., Whitington, P.F., ... Sokol, R.J. (2014). Use of corticosteroids after hepatoportoenterostomy for bile drainage in infants with biliary atresia: The START randomized clinical trial. JAMA, 311(17), 1750-1759. DOI: https://doi.org/10.1001/jama.2014.2623

Bezerra, J.A., Wells, R.G., Mack, C.L., Karpen, S.J., Hoofnagle, J.H., Doo, E., & Sokol, R.J. (2018). Biliary atresia: Clinical and research challenges for the twenty-first century. Hepatology, 68(3), 1163-1173. DOI: https://doi.org/10.1002/hep.29905

Brahee, D.D., & Lampl, B.S. (2022). Neonatal diagnosis of biliary atresia: A practical review and update. Pediatric Radiology, 52(4), 685-692. DOI: https://doi.org/10.1007/s00247-021-05148-y

Cosme, M. (2022, April 22). Liver transplantation. Medscape.

Davenport, M. (2017). Adjuvant therapy in biliary atresia: Hopelessly optimistic or potential for change? Pediatric Surgery International, 33(12), 1263-1273. DOI: https://doi.org/10.1007/s00383-017-4157-5

Hartley, J.L., Davenport, M., & Kelly, D.A. (2009). Biliary atresia. The Lancet, 374(9702), 1704-1713. DOI: https://doi.org/10.1016/S0140-6736(09)60946-6

Hoshino, E., Hayashi, K., Suzuki, M., Obatake, M., Urayama, K.Y., Nakano, S., Taura, Y., Nio, M., & Takahashi, O. (2017). An iPhone application using a novel stool color detection algorithm for biliary atresia screening. Pediatric Surgery International, 33(10), 1115-1121. DOI: https://doi.org/10.1007/s00383-017-4146-8

Lakshminarayanan, B., & Davenport, M. (2016). Biliary atresia: A comprehensive review. Journal of Autoimmunity, 73, 1-9. DOI: https://doi.org/10.1016/j.jaut.2016.06.005

LeeVan, E., Matsuoka, L., Cao, S., Groshen, S., & Alexopoulos, S. (2019). Biliary-enteric drainage vs primary liver transplant as initial treatment for children with biliary atresia. JAMA Surgery, 154(1), 26-32. DOI: https://doi.org/10.1001/jamasurg.2018.3180

Nio, M., Wada, M., Sasaki, H., Tanaka, H., & Watanabe, T. (2015). Long-term outcomes of biliary atresia with splenic malformation. Journal of Pediatric Surgery, 50(12), 2124-2127. DOI: https://doi.org/10.1016/j.jpedsurg.2015.08.040

Robie, D.K., Overfelt, S.R., Xie, L. (2014). Differentiating biliary atresia from other causes of cholestatic jaundice. Am Surg, 80(9), 827-831. DOI: https://doi.org/10.1177/000313481408000908

Schwarz, S. M. (2024, July 19). Pediatric biliary atresia. Medscape.

Tam, P. K. H., Wells, R. G., Tang, C. S. M., Lui, V. C. H., Hukkinen, M., Luque, C. D., ... & Bezerra, J. A. (2024). Biliary atresia. Nature Reviews Disease Primers, 10(1), 47. DOI: https://doi.org/10.1038/s41572-024-00533-x

Wang, L., Yang, Y., Chen, Y., & Zhan, J. (2018, April). Early differential diagnosis methods of biliary atresia: A meta-analysis. Pediatric Surgery International, 34(4), 363-380. DOI: https://doi.org/10.1007/s00383-018-4229-1

Kurylo, H.V. (2025). Transplantatsiya pechinky v ditey: taktyka dotransplantatsiynoyi pidhotovky [Liver transplantation in children: tactics of pretransplantation]. Khirurhiya dytyachoho viku (Ukrayina) [Surgery of the pediatric age (Ukraine)], 1(86), 40-44. [in Ukrianian]. DOI: 10.15574/PS.2025.1(86).4044. DOI: https://doi.org/10.15574/PS.2025.1(86).4044

Downloads

Published

2025-12-15

How to Cite

Besh, L. V., Matsyura, O. I., Slyuzar, Z. L., & Lyalyuk, D. S. (2025). LIVER TRANSPLANTATION IN A CHILD DUE TO BILIARY ATRESIA: A CLINICAL CASE. Actual Problems of Pediatrics, Obstetrics and Gynecology, (2), 113–115. https://doi.org/10.11603/24116-4944.2025.2.15824

Issue

No. 2 (2025)

Section

PEDIATRICS

License

Copyright (c) 2026 Л. В. Беш, О. І. Мацюра, З. Л. Слюзар, Д. С. Лялюк

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish in this journal agree to the following terms:

1. The authors reserve the right to authorship of the work and pass the journal right of first publication of this work is licensed under a Creative Commons Attribution License, which allows others to freely distribute the work published with reference to the authors of the original work and the first publication of this magazine.

Результат пошуку зображень за запитом "CC-BY logo"

 2. Authors are entitled to enter into a separate agreement on additional non-exclusive distribution of work in the form in which it was published in the magazine (eg work place in the electronic repository institution or publish monographs in part), provided that the reference to the first publication of this magazine.

3. Policy magazine allows and encourages authors placement on the Internet (eg, in storage facilities or on personal websites) manuscript of how to submit the manuscript to the editor and during his editorial processing, since it contributes to productive scientific discussion and positive impact on the efficiency and dynamics of citing published work (see. The Effect of Open Access).