HALITOSIS AS AN ADDITIONAL CLINICAL MARKER OF STREPTOCOCCAL TONSILLITIS IN CHILDREN: OUTPATIENT OBSERVATION
DOI:
https://doi.org/10.11603/24116-4944.2025.2.15820Keywords:
halitosis, streptococcal tonsillitis, pediatric diagnosis, group A β-hemolytic streptococcus (GABHS), oral malodor, chronic tonsillitis, rapid antigen test, bacterial pharyngitis, outpatient pediatrics, diagnostic markersAbstract
The aim of the study – to evaluate the clinical significance of halitosis as a supplementary marker of streptococcal tonsillitis in children aged 3–18, including its correlation with confirmed Group A β-hemolytic streptococcal (GABHS) infection.
Materials and Methods. A total of 279 children presenting with symptoms of acute or chronic tonsillopharyngitis were assessed between January and May 2025. Clinical examination included halitosis evaluation and a rapid antigen test for GABHS. Patients with non-streptococcal or unrelated conditions were excluded.
Results and Discussion. Of 190 children with confirmed streptococcal infection, halitosis was observed in 128 (67.4 %). The symptom was most prevalent in follicular (89.3 %) and lacunar (78.5 %) tonsillitis and during exacerbations of chronic tonsillitis (81 %). Younger children (7–10 years) exhibited the highest prevalence (73.2 %). Halitosis intensity was moderate in 50.8 % and severe in 27.3 % of cases. A strong correlation was found between halitosis and positive rapid streptococcal test results (87.5 % of halitosis cases were GABHS-positive), versus 36 % among viral cases.
Conclusions. Halitosis may be a valuable, easily detectable marker for streptococcal pharyngotonsillitis in children, especially in settings with limited diagnostic tools. Its integration into clinical algorithms could improve early identification of bacterial infections and guide antibiotic prescribing, supporting efforts to reduce antibiotic resistance.
References
Yoo, H.J., Jwa, S.K., Kim, D.H., & Ji, Y.J. (2020). Inhibitory effect of Streptococcus salivarius K12 and M18 on halitosis in vitro. Clinical and experimental dental research, 6(2), 207–214. https://doi.org/10.1002/cre2.269. DOI: https://doi.org/10.1002/cre2.269
Sikorska-Żuk, M., & Bochnia, M. (2018). Halitosis in children with adenoid hypertrophy. Journal of breath research, 12(2), 026011. https://doi.org/10.1088/1752-7163/aa9b3a. DOI: https://doi.org/10.1088/1752-7163/aa9b3a
Bawazir, O.A. (2021). Risk Factors, Diagnosis, and Management of Halitosis in Children: A Comprehensive Review. The journal of contemporary dental practice, 22(8), 959–963. DOI: https://doi.org/10.5005/jp-journals-10024-3139
Smith, K.L., Hughes, R., & Myrex, P. (2023). Tonsillitis and Tonsilloliths: Diagnosis and Management. American family physician, 107(1), 35–41.
Brant Pinheiro, S.V., de Freitas, V.B., de Castro, G.V., Rufino Madeiro, B.C., de Araújo, S.A., Silva Ribeiro, T.F., & Simões E Silva, A.C. (2022). Acute Post-Streptococcal Glomerulonephritis in Children: A Comprehensive Review. Current medicinal chemistry, 29(34), 5543–5559. https://doi.org/10.2174/0929867329666220613103316. DOI: https://doi.org/10.2174/0929867329666220613103316
Sika-Paotonu, D., Beaton, A., Raghu, A., ... & Fischetti, V.A. Acute Rheumatic Fever and Rheumatic Heart Disease. 2017 Mar 10 [Updated 2017 Apr 3]. In: Ferretti J.J., Stevens D.L., Fischetti V.A., editors. Streptococcus pyogenes: Basic Biology to Clinical Manifestations [Internet]. Oklahoma City (OK): University of Oklahoma Health Sciences Center; 2016. Available from: https://www.ncbi.nlm.nih.gov/books/NBK425394/.
Gokdogan, O., Catli, T., & Ileri, F. (2015). Halitosis in otorhinolaryngology practice. Iranian journal of otorhinolaryngology, 27(79), 145–153.
Tungare, S., Zafar N., & Paranjpe, A.G. Halitosis. [Updated 2023 Aug 14]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK534859/.
Aylıkcı, B.U., & Colak, H. (2013). Halitosis: From diagnosis to management. Journal of natural science, biology, and medicine, 4(1), 14–23. https://doi.org/10.4103/0976-9668.107255. DOI: https://doi.org/10.4103/0976-9668.107255
Bondarenko, Y., & Birjukova, M. (2025). Etiopathogenetic mechanisms of recurrent tonsillitis development in children in organized groups. Grail of Science, 49, 1109–1119. https://doi.org/10.36074/grail-of-science.21.02.2025.158. DOI: https://doi.org/10.36074/grail-of-science.21.02.2025.158
Bondarenko, Y., Zhuravel, Y., & Ognev, V. (2025). Determinants of health in preschool and school-age children: challenges of recurrent tonsillitis. Grail of Science, 49, 1089–1100. https://doi.org/10.36074/grail-of-science.21.02.2025.157. DOI: https://doi.org/10.36074/grail-of-science.21.02.2025.157
Yaegaki, K., & Sanada, K. (1992). Biochemical and clinical factors influencing oral malodor in periodontal patients. Journal of periodontology, 63(9), 783–789. https://doi.org/10.1902/jop.1992.63.9.783. DOI: https://doi.org/10.1902/jop.1992.63.9.783
Bondarenko, Y., & Biriukova, M. (2025). Clinical and Diagnostic Significance of the Color and Consistency of Discharge from the Upper and Lower Respiratory Tracts in Assessing the Bacterial or Viral Etiology of Disease. Young Scientist, 2(133), 25–31. https://doi.org/10.32839/2304-5809/2025-2-133-33. DOI: https://doi.org/10.32839/2304-5809/2025-2-133-33
Guntinas-Lichius, O., Geißler, K., Mäkitie, A.A., Ronen, O., Bradley, P.J., Rinaldo, A., ... & Ferlito, A. (2023). Treatment of recurrent acute tonsillitis-a systematic review and clinical practice recommendations. Frontiers in surgery, 10, 1221932. https://doi.org/10.3389/fsurg.2023.1221932. DOI: https://doi.org/10.3389/fsurg.2023.1221932
Sharma, K., Das, S., & Goswami, A. (2022). A Study on Acute Membranous Tonsillitis, Its Different Etiologies and Its Clinical Presentation in a Tertiary Referral Centre. Indian journal of otolaryngology and head and neck surgery: official publication of the Association of Otolaryngologists of India, 74(Suppl 3), 4543–4548. https://doi.org/10.1007/s12070-021-02572-2. DOI: https://doi.org/10.1007/s12070-021-02572-2
Sidell, D., & Shapiro, N.L. (2012). Acute tonsillitis. Infectious disorders drug targets, 12(4), 271–276. https://doi.org/10.2174/187152612801319230. DOI: https://doi.org/10.2174/187152612801319230
Windfuhr, J.P., Toepfner, N., Steffen, G., Waldfahrer, F., & Berner, R. (2016). Clinical practice guideline: tonsillitis I. Diagnostics and nonsurgical management. European archives of oto-rhino-laryngology: official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS): affiliated with the German Society for Oto-Rhino-Laryngology – Head and Neck Surgery, 273(4), 973–987. https://doi.org/10.1007/s00405-015-3872-6. DOI: https://doi.org/10.1007/s00405-015-3872-6
Bird, J.H., Biggs, T.C., & King, E.V. (2014). Controversies in the management of acute tonsillitis: an evidence-based review. Clinical otolaryngology: official journal of ENT-UK; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery, 39(6), 368–374. https://doi.org/10.1111/coa.12299. DOI: https://doi.org/10.1111/coa.12299
Abu Bakar, M., McKimm, J., Haque, S.Z., Majumder, M.A.A., & Haque, M. (2018). Chronic tonsillitis and biofilms: a brief overview of treatment modalities. Journal of inflammation research, 11, 329–337. https://doi.org/10.2147/JIR.S162486. DOI: https://doi.org/10.2147/JIR.S162486
Alrayah, M. (2023). The Prevalence and Management of Chronic Tonsillitis: Experience From Secondary Care Hospitals in Rabak City, Sudan. Cureus, 15(2), e34914. https://doi.org/10.7759/cureus.34914. DOI: https://doi.org/10.7759/cureus.34914
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