RESULTS OF A RETROSPECTIVE ANALYSIS OF THE COURSE OF PREGNANCY, CHILDBIRTH AND PERINATAL OUTCOMES IN WOMEN – INTERNALLY DISPLACED PERSONS WITH A THREAT OF PREGNANCY TERMINATION

Authors

DOI:

https://doi.org/10.11603/24116-4944.2024.2.15085

Keywords:

pregnancy, spontaneous premature childbirth, premature rupture of membranes, vaginal microbiocenosis

Abstract

The aim of the study – to establish the main risk factors for the threat of termination of pregnancy and the development of premature birth in internally displaced women and to develop highly specific criteria for individual prognosis in order to improve perinatal outcomes based on retrospective analysis.

Materials and Methods. A retrospective study of 250 histories of pregnancy and childbirth of women – internally displaced persons, who had a threat of abortion in the Ist and IInd trimesters and premature birth in the gestational period of 22–36 weeks, was conducted. We studied the peculiarities of the course of pregnancy, childbirth of the examined women who were in hospital treatment for the threat of abortion, as well as those who were observed in outpatient health care Sumy city institutions during 2022-2024. The condition of their newborns was also investigated.

Results and Discussion. Important risk factors for premature rupture of membranes (PROM) in preterm pregnancy included the presence of sexually transmitted diseases (χ2=31.188, p=0.001), bacterial vaginosis (χ2=30.913, p=0.0001), a history of abortion and/or preterm birth (χ2=16.62, p=0.0002), acute respiratory viral infections during pregnancy (χ2=16.444, p=0.0002), chronic adnexitis in anamnesis (χ2=11.522, p=0.0031), inflammatory cervical disease (χ2=11.437, p=0.0032), anaemia (χ2=10.815, p=0.0044), isthmic-cervical insufficiency (ІСІ) (χ2=10.345, p=0.0057), chronic pyelonephritis with exacerbation (χ2=9.16, p=0.01), smoking during pregnancy (χ2=10.815, p=0.0044).

Conclusions. The results of a retrospective analysis of 250 cases of preterm birth at 22 to 36 weeks allowed us to identify ways to effectively use existing diagnostic measures to determine readiness for pregnancy and the possibility of prolonging pregnancy to the viability of the newborn. Ways to improve the prevention of preterm birth and the design of further research were identified.

Author Biographies

V. V. Dіadіushka, Sumy State University

obstetrician-gynecologist, postgraduate student of the Department of Obstetrics

I. M. Nikitina, Sumy State University

Doctor of Medical Sciences, Professor of the Department of Obstetrics, Gynecology and Family Planning

V. I. Boіko, Sumy State University

Doctor of Medical Sciences, Professor, Head of the Department of Obstetrics, Gynecology and Family Planning

T. V. Babar, Sumy State University

Candidate of Medical Sciences, Associate Professor of the Department of Obstetrics, Gynecology and Family Planning

N. V. Kalashnyk, Sumy State University

Candidate of Medical Sciences, Associate Professor of the Department of Obstetrics, Gynecology and Family Planning

References

Kim, C. J., Romero, R. & Chaemsaithong Р. (2015). Acute chorioamnionitis and funisitis: definition, pathologic features, and clinical significance. Am J Obstet Gynecol., 213(4), 29-52. DOI: 10.1016/j.ajog.2015.08.040. DOI: https://doi.org/10.1016/j.ajog.2015.08.040

Gorbenko, N. I., Borikov, O. Yu. & Ivanova, O. V. (2019). The effect of quercetin on oxidative stress markers and mitochondrial permeability transition in the heart of rats with type 2 diabetes. Ukr. Biochem. J., 91(5), 46-54. DOI: https://doi.org/10.15407/ubj91.05.046

Vitale, S. G., Marilli, І. & Rapisarda, А. М. (2014). Cellular and biochemical mechanisms, risk factors and management of preterm birth: state of the art. Minerva Ginecol., 66(6), 589-595.

Areia, A. L., Moura, Р. & Mota-Pinto А. (2019). The role of innate immunity in spontaneous preterm labor: A systematic reviеw. J. Reprod. Imunol., 136, 102-616. DOI: https://doi.org/10.1016/j.jri.2019.102616

Weiner, Е., Barrett, J. & Zaltz А. (2019). Amniotic fluid volume at presentation with early preterm prelabor rupture of membranes and association with severe neonatal respiratory morbidity. Ultrasound Obstet Gynecol., 54 (6), 767-773. DOI: 10.1002/uog.20257. DOI: https://doi.org/10.1002/uog.20257

He, X. G., Xu, F. D. & Li J. F. (2020). Effect of different antibiotic use strategies on infection in neonates with premature rupture of membranes and high-risk factors for neonatal infection. Zhongguo Dang Dai Er Ke Za Zhi., 22 (4), 310-315. DOI: 10.7499/j.issn.1008-8830.1910170.

Ehsanipoor, R., Pettker, С. М. (2020). Prelabor Rupture of Membranes. ACOG Practice Bulletin, Number 217 Practice Guideline. Obstet Gynecol., 135(3), 80-97. DOI: 10.1097/AOG.0000000000003700. DOI: https://doi.org/10.1097/AOG.0000000000003700

Romero, R., Gomez-Lopez, N. & Winters, A. D. (2019). Evidence that intra-amniotic infections are often the result of an ascending invasion a molecular microbiological study. J. Perinat Med., 47 (9), 915-931. DOI: 10.1515 / jpm-2019-0297. DOI: https://doi.org/10.1515/jpm-2019-0297

Brown, R. G., Al-Memar, М. & Marchesi J. R. (2019). Establishment of vaginal microbiota composition in early pregnancy and its association with subsequent preterm prelabor rupture of the fetal membranes. Transl. Res., 207, 30-43. DOI: https://doi.org/10.1016/j.trsl.2018.12.005

Cobo, Т., Jacobsson, В. & Kacerovsky, М. (2017). Systemic and Local Inflammatory Response in Women with Preterm Prelabor Rupture of Membranes. PLoS One, 12(10), 95-905. DOI: https://doi.org/10.1371/journal.pone.0095905

Carrapato, M. R. G., Pereira, Т. & Silva, М. (2018). Late preterms: are they all the same? J. Matern. Fetal. Neonatal. Med., 29, 1-6. DOI: 10.1080/14767058.2018.1527897. DOI: https://doi.org/10.1080/14767058.2018.1527897

Sim, W. H. & Sheehan, Р. (2020). Maternal and neonatal outcomes following expectant management of preterm prelabor rupture of membranes before viability. J. Matern. Fetal. Neonatal. Med., 33(4), 533-541. DOI: 10.1080/147677058.2018.1495706. DOI: https://doi.org/10.1080/14767058.2018.1495706

Published

2025-01-22

How to Cite

Dіadіushka V. V., Nikitina, I. M., Boіko V. I., Babar, T. V., & Kalashnyk, N. V. (2025). RESULTS OF A RETROSPECTIVE ANALYSIS OF THE COURSE OF PREGNANCY, CHILDBIRTH AND PERINATAL OUTCOMES IN WOMEN – INTERNALLY DISPLACED PERSONS WITH A THREAT OF PREGNANCY TERMINATION. Actual Problems of Pediatrics, Obstetrics and Gynecology, (2), 55–60. https://doi.org/10.11603/24116-4944.2024.2.15085

Issue

Section

OBSTETRICS AND GYNECOLOGY