THE EFFECT OF INOSITOL ON WOMEN WITH POLYCYSTIC OVARY SYNDROME AND OBESITY: METABOLIC AND REPRODUCTIVE ASPECTS
(LITERATURE REVIEW)
DOI:
https://doi.org/10.11603/24116-4944.2024.1.14741Keywords:
infertility, obesity, polycystic ovary syndrome, insulin resistance, anovulation, inositolAbstract
The aim of the study - to assess the impact of obesity and determine the effectiveness of pregravid preparation in patients with polycystic ovary syndrome (PCOS) in assisted reproductive technology (ART) protocols.
Materials and Methods. A systematic review and comparative analysis of 44 scientific publications and literature sources from the PubMed database over the past 5 years related to research in the field of reproductive medicine on the impact of polycystic ovary syndrome and obesity on the reproductive potential of women and methods of pathogenetic correction at the stage of pregravid preparation was conducted.
Results and Discussion. The analysis of literature data showed that inositol helps to improve the metabolic profile, reduce insulin resistance and regulate hormonal balance. In addition, inositol intake improves reproductive functions and helps to improve the quality of eggs in in vitro fertilization protocols. The results confirm the feasibility of using inositol as part of a comprehensive approach to the treatment of women with PCOS and obesity, opening up prospects for further research in this area.
Conclusions. Polycystic ovary syndrome is a complex heterogeneous disease that requires an integrated approach to management. The use of inositol in women with comorbid PCOS and obesity demonstrates positive effects in the context of the metabolic profile and reproductive health of this group of women.
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