PLACENTAL INSUFFICIENCY, PRO-INFLAMMATORY CYTOKINES AND THE SARS-COV-2 VIRUS
DOI:
https://doi.org/10.11603/24116-4944.2024.1.14740Keywords:
cytokines, pregnancy, SARS-CoV-2Abstract
The aim of the study – to study the levels of pro-inflammatory cytokines in pregnant women with placental insufficiency and SARS-CoV-2 in pregnant women.
Materials and Methods. We examined 60 pregnant women (the main group) with transmitted SARS-CoV-2, confirmed by the PCR method during pregnancy, with placental insufficiency due to intrauterine growth retardation syndrome (IFRS) of the II-III degrees (group 2 - 20 women) and with placental insufficiency without SIRF (1 group – 40 women) in the period of 32–34 weeks of pregnancy. The control group consisted of 25 women with an uncomplicated pregnancy. To study the concentration of pro-inflammatory cytokines in the blood (tumor necrosis factor-α (TNF-α), interleukin-1-β (IL-1-β), interleukin-6 (IL-6)) reagents manufactured by the company "Vector-Best" were used (Ukraine). Statistical analysis was performed using Microsoft Excel and "Statistica -10" software.
Results and Discussion. A significant (p<0.05) increase in the level of IL-1-β compared to controls was observed in pregnant women with placental insufficiency, which was realized as a delay in intrauterine development of the fetus against the background of post-covid syndrome. Levels of other pro-inflammatory cytokines, namely TNF-α and IL-6, were also increased in the blood of women in the experimental group (p<0.05) compared to the norm. Taking this into account, it can be assumed that SARS-CoV-2 plays a negative role in the establishment of physiological relationships between the immune system of the mother and pregnancy both at the stage of implantation and in later stages of gestation and needs further study in its role in the development of complicated pregnancy.
Conclusions. It can be considered an established fact that the SARS-CoV-2 virus in pregnant women probably has a negative effect on the course of pregnancy and contributes to the development of placental insufficiency, which is realized in the form of a delay in intrauterine development of the fetus and is accompanied by activation of the pro-inflammatory link of immunity, manifested in the form of an increase in TNF levels -α, IL-1-β and IL-6.
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