DIAGNOSTIC CAPACITY OF ULTRASOUND AND MORPHOLOGICAL STUDY OF THE ENDOMETRIUM CONDITION IN PATIENTS WITH INFERTILITY AND A COMPROMISED COVID-19 ANAMNESIS
DOI:
https://doi.org/10.11603/24116-4944.2024.1.14738Keywords:
SARS-CoV-2 virus, post-covid syndrome, coronavirus disease-2019, endometrium, ultrasound diagnostics, morphological examination, infertility, assisted reproductive technologiesAbstract
The aim of the study – to assess sonographic and histopathological examination informativeness in women with infertility and post-COVID syndrome anamnesis.
Materials and Methods. During 2022-2023, 69 women with diagnosed infertility and a moderate to severe course of COVID-19 (and the subsequent development of post-covid syndrome) in the study group and 62 women with infertility without a compromised COVID-19 anamnesis were examined. The chosen research methods were: ultrasound diagnosis of pelvic organs and morphological samples of endometrial tissue.
Results and Discussion. During ultrasound, the following indicators were evaluated, which were unified into the following 4 categories: changes in the echogenicity of the endometrium, changes in hemodynamics in the uterine arteries, changes in the uterine cavity, changes in the thickness and structure of the myometrium. During the morphological analysis, the features that were of interest and were ranked as distinctive included plasma cells in the field of view, lymphohistiocytic infiltration, detection of loci of fibrotic stroma, groups of spiral endometrial arteries with sclerotic changes. The study group was characterized by the presence of all 4 morphological signs in 7 people (10%), the maximum number of 3 signs was detected in the comparison group. The minimum number of pathohistological signs was 2 in the study group, while in the comparison group there was only one sign in 4 cases (6.5%). In the study group, when conducting a correlation analysis between the number of detected ultrasonic and morphological signs, a relationship of moderate strength was established (r=0.444, р=0.0046). To analyze the quality of the ultrasound diagnostic test in the assessment of the endometrium condition, a ROC curve was constructed, the area under which was 0.722, p=0.013, which was determined as a good quality of the classifier.
Conclusions. Ultrasound diagnostics has a good diagnostic ability in assessing of the endometrium condition, and a moderate correlation has been established between the number of ultrasound and morphological signs of endometrial pathology in women with a post-COVID syndrome anamnesis.
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