TISSUE HYPOXIA OF THE RENAL PARENCHYMA IN CHILDREN WITH DYSMETABOLIC NEPHROPATHY
DOI:
https://doi.org/10.11603/24116-4944.2024.2.14710Keywords:
dysmetabolic nephropathy, children, tissue hypoxia, calcium phosphates, calcium oxalatesAbstract
The aim of the study – to determine the role of tissue hypoxia in children with dysmetabolic nephropathy in the pathogenesis of this pathology.
Materials and Methods. Two groups of children were examined: those with a complicated course of dysmetabolic nephropathy (cDMN), with the presence of an episode of inflammation of the urinary system in the past (group I – cDMN, 52 children), and dysmetabolic nephropathy with persistent crystalluria (group II – DMN, 56 children). Indicators characterizing the degree of tissue hypoxia of the renal parenchyma were determined in children of both groups: the anti-crystallizing ability of urine and the daily excretion of oxalates and phosphates in children, which not only verify the diagnosis of dysmetabolic nephropathy but also to diagnose the presence of tissue hypoxia of the renal parenchyma.
Results and Discussion. The analysis showed that the anti-crystallizing ability of urine to calcium oxalates and calcium phosphates was significantly reduced in all examined children of both groups, with a tendency to decrease more significantly in children with severe cDMN. In all 100.0 % of the examined children of both groups, the daily urinary excretion of calcium oxalates and calcium phosphates was significantly (2–3 times) higher, with a tendency to greater excretion in children with complicated courses of DMN.
Conclusions. The obtained data suggest that children with dysmetabolic nephropathy require antihypoxic agent therapy in the complex treatment of dysmetabolic nephropathy.
References
Ruas, A. F. L., Lébeis, G. M., de Castro, N. B., Palmeira, V. A., Costa, L. B., Lanza, K., & Simões e Silva, A. C. (2022). Acute kidney injury in pediatrics: an overview focusing on pathophysiology. Pediatric Nephrology, 37(9), 2037–2052. DOI: https://doi.org/10.1007/s00467-021-05346-8
Wang, L., He, J., Xu, K., & Zhu, W. (2021). Differential expressions of TGF-β1, HIF-1, VEGF, α-SMA and E-cadherin in renal tissues of a neonatal rat model of hydronephrosis. Tropical Journal of Pharmaceutical Research, 20(9), 1855–1860. DOI: https://doi.org/10.4314/tjpr.v20i9.11
Huang, L. T., & Chen, C. M. (2022). Kidney Injuries and Evolution of Chronic Kidney Diseases Due to Neonatal Hyperoxia Exposure Based on Animal Studies. International journal of molecular sciences, 23(15), 8492. DOI: https://doi.org/10.3390/ijms23158492
Wang, B., Li, Z. L., Zhang, Y. L., Wen, Y., Gao, Y. M., & Liu, B. C. (2022). Hypoxia and chronic kidney disease. EBioMedicine, 77. DOI: https://doi.org/10.1016/j.ebiom.2022.103942
Della Rocca, Y., Fonticoli, L., Rajan, T. S., Trubiani, O., Caputi, S., Diomede, F., ... & Marconi, G. D. (2022). Hypoxia: molecular pathophysiological mechanisms in human diseases. Journal of physiology and biochemistry, 78(4), 739–752. DOI: https://doi.org/10.1007/s13105-022-00912-6
Myroshnychenko, M. (2022). The effect of different types of hypoxia on the morpho-functional state of the kidneys of fetuses and newborns: the results of own long-term experimental studies. Inter Collegas, 9(1), 86–92. DOI: https://doi.org/10.35339/ic.9.1.86-92
Liang, P., Chen, Y., Li, S., Xu, C., Yuan, G., Hu, D., ... & Li, Z. (2021). Noninvasive assessment of kidney dysfunction in children by using blood oxygenation level-dependent MRI and intravoxel incoherent motion diffusion-weighted imaging. Insights into Imaging, 12, 1–13. DOI: https://doi.org/10.1186/s13244-021-01091-6
Luo, F., Liao, Y., Cui, K., & Tao, Y. (2020). Noninvasive evaluation of renal oxygenation in children with chronic kidney disease using blood-oxygen-level-dependent magnetic resonance imaging. Pediatric Radiology, 50, 848–854. DOI: https://doi.org/10.1007/s00247-020-04630-3
Sugahara, M., Tanaka, T., & Nangaku, M. (2020). Hypoxia-inducible factor and oxygen biology in the kidney. Kidney360, 1(9), 1021–1031. DOI: https://doi.org/10.34067/KID.0001302020
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Н. Р. Айб, Н. С. Лук’яненко, К. А. Кенс
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish in this journal agree to the following terms:
1. The authors reserve the right to authorship of the work and pass the journal right of first publication of this work is licensed under a Creative Commons Attribution License, which allows others to freely distribute the work published with reference to the authors of the original work and the first publication of this magazine.
2. Authors are entitled to enter into a separate agreement on additional non-exclusive distribution of work in the form in which it was published in the magazine (eg work place in the electronic repository institution or publish monographs in part), provided that the reference to the first publication of this magazine.
3. Policy magazine allows and encourages authors placement on the Internet (eg, in storage facilities or on personal websites) manuscript of how to submit the manuscript to the editor and during his editorial processing, since it contributes to productive scientific discussion and positive impact on the efficiency and dynamics of citing published work (see. The Effect of Open Access).
