THE STATE OF REDOX HAEMOSTASIS IN PATIENTS WITH DYSHORMONAL BREAST DISEASES IN COMORBIDITY WITH GENITAL ENDOMETRIOSIS
DOI:
https://doi.org/10.11603/24116-4944.2023.2.14338Keywords:
redox haemostasis, dyshormonal diseases, mammary glands, comorbidity, genital endometriosis, oxidant-antioxidant systemAbstract
The aim of the study - is to assess the state of oxidant and antioxidant system in patients with dyshormonal breast diseases in comorbidity with genital endometriosis.
Materials and Methods. The study included 90 patients with dyshormonal breast diseases in comorbidity with genital endometriosis and 25 women in the control group. The patients were divided into three groups depending on the method of treatment: the first group consisted of 30 patients who received progesterone hormone therapy from day 11 to day 25 of the menstrual cycle for 3 months; the second group (30) received gonadotropin-releasing hormone agonists (a-GnRH) monthly for 3 menstrual cycles; the third group (30 patients) received our proposed treatment regimen with the use of gonadotropin-releasing hormone agonists monthly for 3 menstrual cycles with additional administration of Vitex agnus castus herb extract BNO 1095 and the antioxidant selenium active at a dose of 200 mg per day for three months. The study was conducted in accordance with current clinical protocols. BI-RADS Breast Imaging-Reporting and Data System is a standardised scale for assessing the results of mammography, ultrasound and MRI for the risk of breast cancer. To assess the intensity of free radical oxidation in patients, the content of diene conjugates (DC) was determined by the method of I.D. Stalnaya, malondialdehyde (MDA) by the method of I.D. Stalnaya and T.G. Garishvili. The activity of superdismutase (SDS) and glutathione reductase (GR) was studied spectrophotometrically at 340 nm.
Results and Discussion. After analysing the data obtained, complaints of lumping, increased volume, increased sensitivity and tenderness during breast palpation in the second phase of the menstrual cycle were observed in 88 (97.8 %) of the subjects. Infertility was the reason for the visit in 30 (33.3 %) patients and menstrual irregularities in 40 (44.4 %) patients. Changes in the mammary glands were determined by the BI-RADS scale. The analysis of the obtained data revealed that in patients with dyshormonal breast diseases in comorbidity with genital endometriosis, there is an increase in the activity of lipid peroxidation, as evidenced by an increase in the level of MDA and DC. The administration of the developed complex trapezoid allows to normalise the ratio of lipid peroxidation and antioxidant system.
Conclusions. It was found that in the plasma of patients of the study group there was an increase in the activity of lipid peroxidation and an decrease in the activity of glutathione reductase and a recurrent decrease in the activity of superoxide dismutase. The described changes are characteristic of metabolic acidosis and indicate a strain on adaptive capacities. The administration of the developed complex trapezoid allows to normalise the ratio of lipid peroxidation and antioxidant system.
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