FEATURES OF THE ALGORITHM OF CLINICAL AND LABORATORY DIAGNOSIS OF LYME BORRELIOSIS IN CHILDREN
DOI:
https://doi.org/10.11603/24116-4944.2023.2.14256Keywords:
Lyme disease, children, immunofluorescence analysis, ELISA test, blot testAbstract
The aim of the study – to improve the algorithm of clinical and laboratory diagnosis of Lyme borreliosis in children.
Materials and Methods. The search and analysis of available literature sources of the PubMed database is carried out, using a combination of keywords "Lyme disease in children", " Clinical and Laboratory diagnostic". A group of children (62) aged 1 to 17 years was observed to identify pathogens of haemotransmissible infections among children. C-reactive protein (CRP) was determined, which is a protein and reagent of the acute phase. To confirm the diagnosis of PM, determine the form of the lesion and identify the antigens of the pathogen, a routine two-step method of blood analysis was used.
Results and Discussion. The algorithm for the diagnosis of Lyme borreliosis in children has been developed for use in making a diagnosis. Clinical: complaints – malaise, fatigue, headache, arthralgia, myalgia, subfebrile body temperature; anamnesis – tick bites, location of bites, time of appearance of symptoms after the bite; objective – lymphadenopathy, arthritis, pain syndrome, intoxication syndrome; laboratory and instrumental diagnostics: biochemical blood analysis (increased level of C-reactive protein, rheumatoid factor is rarely detected), ultrasound of joints, immunological examination (immunofluorescence analysis and blot test), detection of Borrelia by PCR method in synovial fluid.
Conclusions. Proposed algorithm for diagnosing the Lyme disease in children.
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