MULTISYSTEM INFLAMMATORY SYNDROME (MIS-C) ASSOCIATED WITH CORONAVIRUS INFECTION IN CHILDHOOD: A COHORT STUDY IN UKRAINE
DOI:
https://doi.org/10.11603/24116-4944.2023.2.14240Keywords:
multisystem inflammatory syndrome in children, MIS-C, PIMS-TS, SARS-CoV-2, Coronavirus, COVID-19, childrenAbstract
The aim of the study – to identify the clinical and laboratory features of MIS-C in children based on gender, age, and disease severity, and establish a statistical clinical-laboratory correlation for the purpose of predicting the course of the disease.
Materials and Methods. Cohort observation of a group of children conducted in healthcare institutions from September 2020 to September 2022. Patients aged 1 month to 18 years who met the diagnostic criteria for MIS-C according to the CDC [1].
Results And Discussion. Forty-seven children were examined, of which 27 (57.4 %) were boys and 20 (42.6 %) were girls. Among boys, the most common age group affected was 6–11 years (31.91 %), while among girls, it was 2–5 years (19.15 %). Males were more prone to a severe course of multisystem inflammatory syndrome compared to the female group. In female patients, the hyperinflammatory syndrome was characterized by more frequent elevation of ESR, CRP, leukocytes, lymphocytes, and fibrinogen levels, while in boys, there were higher levels of procalcitonin, neutrophils, hypoalbuminemia, and D-dimer. No significant correlation was found between organ and system involvement and gender. Neurological symptoms were equally observed in patients regardless of the course of MIS, whereas other organs and systems were more frequently involved in patients with a severe degree.
Conclusion. The features of the course of multisystem inflammatory syndrome in children in the observation group, depending on age, gender, and clinical presentation, can be used by clinicians to predict the course and involve specific organs and systems.
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