THERAPEUTIC STRATEGIES IN CORRECTION OF THE PROGRAM OF VAGINAL MICROBIOTA IN OVERWEIGHT PATIENTS
DOI:
https://doi.org/10.11603/24116-4944.2023.1.13938Keywords:
overweight, obesity, vaginal candidiasis, bacterial vaginosis, liraglutide, synbiotics, treatment and prevention of relapsesAbstract
The aim of the study – to evaluate the mucosal ecosystem of the vagina and change in its parameters when using the microbiome regulation program in young patients suffering from obesity and dysbiosis.
Materials and Methods. A study of the vaginal microbiome of 120 patients aged 19 to 35 years was conducted: 60 overweight women (group 1) and 30 patients with class I–II obesity (group 2). The control group was formed by 30 patients with a normal body mass index. Treatment of vaginal dysbiosis disorders was supplemented by correction of metabolic imbalance using dietary strategies and pharmacotherapy – an analogue of glucagon-like peptide-1 in combination with a complex of omega-3 polyunsaturated fatty acids and a combined synbiotic.
Results and Discussion. Normocenosis, characteristic of patients with a normal body mass index in 56.7 % of observations, is practically absent in the case of obesity and is only 8.3 % in women with excessive body weight. In the case of excess body weight, a third of the observations showed a predominance of non-specific vaginitis (31.6 %), while in obesity there was an increase in the proportion of both monoinfection (30.0 %) and combination with BV (36.7 %).
Conclusions. With a change in the body mass index and an increase in metabolic abnormalities, the main parameters of the vaginal ecosystem deteriorate – with the predominance of non-specific vaginitis and the combination of VVC with BV. Monitoring and assessment of parameters of the vaginal ecosystem during 12 months demonstrated restoration of normocenosis in the main group up to control parameters, as well as a decrease in the rate of relapses – by 2.6 times.
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