ENDOMETRIAL PATHOLOGY. AGE AND REPRODUCTIVE ASPECTS

Authors

DOI:

https://doi.org/10.11603/24116-4944.2022.2.13457

Keywords:

endometrial pathology, infertility, age categories, hysteroscopy

Abstract

The aim of this study – to study the structure of endometrial pathology, its age-related and reproductive aspects in women who underwent hysteroscopic examination.

Materials and Methods. A retrospective study of the structure of endometrial pathology, its age-related and reproductive aspects was carried out in 1187 women who underwent hysteroscopic examination. Liquid hysteroscopy, ultrasonography, histological examination, and statistical processing methods were used.

Results and Discussion. The study of women of different age with endometrial pathology showed that women of active reproductive age made a majority (55.77 %), patients in the late reproductive and pre-menopausal period made one-third of the sample (36.31%), the least common were menopausal patients age (7.92 %). It turned out that in 55.8 % of cases women of active reproductive age were referred for hysteroscopy mainly because of infertility. A comparison of the structure of endometrial pathology depending on the form of infertility revealed that primary infertility is characterized by hyperplastic changes of the endometrium, while secondary infertility – by inflammatory processes. Women of late reproductive and premenopausal age have the greatest risks of endometrial hyperplasia and chronic endometritis.

Conclusions. It was discovered that endometrial polyps dominate the structure of endometrial pathology in all age groups. The pathological profile of the endometrium with underlying primary infertility is characterized by hyperplastic changes, and with underlying secondary infertility – by inflammatory processes. Hysteroscopic examination significantly improves the diagnosis of pathological changes in the endometrium, especially with primary infertility diagnosis.

Author Biography

S. М. Korniyenko, Odesa National Medical University

MD, Professor, Odesa National Medical University, Department of Obstetrics and Gynecology, Ukraine

References

Temchenko, O.I. (2006). Hiperplastychni protsesy endometriia u zhinok perekhidnoho viku [Hyperplastic processes of the endometrium in women of transitional age]. Nova medytsyna – New Medicine, 2, 38-43 [in Ukrainian].

Cartier, S., Mayrand, M. H., Gougeon, F., & Simard-Émond, L. (2022). Endometrial Biopsy in Low-Risk Women: Are We Over-Investigating? Journal of Obstetrics and Gynecology Canada, 44(10), 1097-1101. DOI: 10.1016/j.jogc.2022.05.010.

Horbatiuk, O.H., Shatkovska, A.S., Hryhorenko, A.P., Binkovska, A.M., & Onyshko, V.Yu. (2017). Metod vidnovlennia retseptyvnosti endometriia pry endometrialnii formi nepliddia [Method of restoration of endometrial receptivity in endometrial form of infertility]. Medychni aspekty zdorovia zhinky – Medical Aspects of Women's Health, 6, 42-44 [in Ukrainian].

McGowan, M.A., Davies, J.M., Addley, S., Honeyman, L.J., Kolhe, S.N., & Phillips, A.J. (2022). Does the presence of single compared to multiple endometrial polyps alter the risk of cancer in post-menopausal women? European Journal of Obstetrics, Gynecology, and Reproductive Biology, 279, 118-121. DOI: 10.1016/j.ejogrb.2022.10.018.

Orishchak, I.K., Makarchuk, O.M., Henyk, N.I., Ostrovska, O.M., & Havryliuk, H.M. (2022). Sonoelastography evaluation in the diagnosis of endometrial pathology combined with chronic endometritis in infertile women. Journal of Medicine and Life, 15(3), 397-404. DOI: 10.25122/jml-2021-0358.

Van Hanegem, N., Prins, M.M., Bongers, M.Y., Opmeer, B.C., Sahota, D.S., Mol, B.W., & Timmermans, A. (2016). The accuracy of endometrial sampling in women with postmenopausal bleeding: a systematic review and meta-analysis. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 197, 147-155. DOI: 10.1016/j.ejogrb.2015.12.008.

De Franciscis, P., Riemma, G., Schiattarella, A., Cobellis, L., Guadagno, M., Vitale, S.G., … Colacurci, N. (2019). Concordance between the Hysteroscopic Diagnosis of Endometrial Hyperplasia and Histopathological Examination. Diagnostics (Basel, Switzerland), 9(4), 142. DOI: 10.3390/diagnostics9040142.

Heremans, R., Van Den Bosch, T., Valentin, L., Wynants, L., Pascual, M. A., Fruscio, R., … IETA Consortium (2022). Ultrasound features of endometrial pathology in women without abnormal uterine bleeding: results from the International Endometrial Tumor Analysis study (IETA3). Ultrasound in Obstetrics & Gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, 60(2), 243-255. DOI: 10.1002/uog.24910.

Sanderson, P.A., Esnal-Zufiaurre, A., Arends, M.J., Herrington, C.S., Collins, F., Williams, A.R.W., & Saunders, P.T.K. (2022). Improving the Diagnosis of Endometrial Hyperplasia Using Computerized Analysis and Immunohistochemical Biomarkers. Frontiers in Reproductive Health, 4, 896170. DOI: 10.3389/frph.2022.896170.

Ring, K.L., Mills, A.M., & Modesitt, S.C. (2022). Endometrial Hyperplasia. Obstetrics and Gynecology, 140(6), 1061-1075. DOI: 10.1097/AOG.0000000000004989.

Tatarchuk, T.F., Dubossarska, Y.O., Dubossarska, Z.М., Reheda, S.I., & Zanko, O.V. (2021). Endometrial hyperplasia: modern approaches to diagnosis and treatment. Reproductive Endocrinology, 2(58), 18-27. DOI: 10.18370/2309-4117.2021.58.18-27.

Korniyenko, S.M. (2011). Histeroskopiya v diahnostytsi ta likuvanni vnutrishnomatkovoyi patolohiyi u zhinok piznoho reproduktyvnoho ta premenopauzalnoho viku [Hysteroscopy in the diagnosis and treatment of intrauterine pathology in women of late reproductive and premenopausal age]. Pediatriya, akusherstvo ta hinekolohiya – Pediatrics, Obstetrics and Gynecology, 73(4), 219-222 [in Ukrainian].

Detti, L., Christiansen, M.E., & Peregrin-Alvarez, I. (2022). Endometrial Abnormalities: Correlation Between Different Diagnostic Modalities. J. Ultrasound Med., 41(8), 1981-1989. DOI: 10.1002/jum.15880.

Xu, Y., & Xie, D. (2022). Prediction of Factors Associated with Abnormal Uterine Bleeding by Transvaginal Ultrasound Combined with Bleeding Pattern. Computational and Mathematical Methods in Medicine, 28, 5653250. DOI: 10.1155/2022/5653250.

Laban, M., El-Swaify, S.T., Ali, S.H., Refaat, M.A., Sabbour, M., & Farrag, N. (2022). Preoperative detection of occult endometrial malignancies in endometrial hyperplasia to improve primary surgical therapy: A scoping review of the literature. International Journal of Gynaecology and Obstetrics, 159(1), 21-42. DOI: 10.1002/ijgo.14139.

Riemma, G., Vitale, S. G., Manchanda, R., Rathore, A., Török, P., De Angelis, C., … Tesarik, J. (2022). The role of hysteroscopy in reproductive surgery: Today and tomorrow. Journal of Gynecology Obstetrics and Human Reproduction, 51(4), 102350. DOI: 10.1016/j.jogoh.2022.102350.

Kravchenko, O.A. (2008). Zastosuvannia histeroskopii u zhinok z hiperplastychnymy protsesamy endometriia [Application of hysteroscopy in women with hyperplastic processes of the endometrium]. Shpytalna khirurhiia – Hospital Surgery, 2, 75-77 [in Ukrainian].

Di Spiezio Sardo, A., Saccone, G., Carugno, J., Pacheco, L.A., Zizolfi, B., Haimovich, S., & Clark, T.J. (2022). Endometrial biopsy under direct hysteroscopic visualisation versus blind endometrial sampling for the diagnosis of endometrial hyperplasia and cancer: Systematic review and meta-analysis. Facts, Views & Vision in Ob. Gyn., 14(2), 103-110. DOI: 10.52054/FVVO.14.2.023.

Al-Asadi, F.A.H.S., & Jasim, S.K. (2022). Accuracy of office hysteroscopy in diagnosis of endometrial pathologies compared to ultrasound and histopathology in Baghdad Teaching Hospital. Journal of Population Therapeutics and Clinical Pharmacology, 29(3), e104-e108. DOI: 10.47750/jptcp.2022.954.

Petersdorf, K., Groettrup-Wolfers, E., Overton, P.M., Seitz, C., & Schulze-Rath, R. (2022). Endometrial hyperplasia in pre-menopausal women: A systematic review of incidence, prevalence, and risk factors. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 271, 158-171. DOI: 10.1016/j.ejogrb.2022.02.015.

Hooker, A.B., de Leeuw, R.A., Emanuel, M.H., Mijatovic, V., Brolmann, H.A.M., & Huirne, J.A.F. (2022). The link between intrauterine adhesions and impaired reproductive performance: a systematic review of the literature. BMC Pregnancy and Childbirth, 22(1), 837. DOI: 10.1186/s12884-022-05164-2.

Published

2022-12-15

How to Cite

Korniyenko S. М. (2022). ENDOMETRIAL PATHOLOGY. AGE AND REPRODUCTIVE ASPECTS. Actual Problems of Pediatrics, Obstetrics and Gynecology, (2), 92–96. https://doi.org/10.11603/24116-4944.2022.2.13457

Issue

Section

OBSTETRICS AND GYNECOLOGY