MULTISYSTEM INFLAMMATORY SYNDROME ASSOCIATED WITH CORONAVIRUS INFECTION IN CHILDHOOD: ANALYSIS OF UKRAINIAN AND EUROPEAN DATA
DOI:
https://doi.org/10.11603/24116-4944.2022.1.13257Keywords:
multisystem inflammatory syndrome, COVID-19, children's age, clinical and laboratory signsAbstract
The aim of the study – to analyze clinical and laboratory signs of MIS-C among children in the observation group and compare them with the main characteristics in European countries.
Materials and Methods. Analysis of 11 medical cards of children undergoing inpatient treatment in Ternopil health care institutions – Ternopil Regional Children’s Hospital and Ternopil City Children’s Hospital from August 2021 to March 2022 for MIS-C associated with SARS-CoV2.
Results and Discussion. The diagnosis of MIS-C was established in 11 children in the Ternopil hospital based on the diagnostic criteria of the protocol approved by the Ministry of Health of Ukraine [10]. The average age of the children was 6.6 years (range 1.7–12.2 years), gender structure boys: girls = 9:2. Ten children (91 %) have a history of contact with COVID-19. Hyperthermic syndrome was noted in all children, cardiovascular system involvement and neurological symptoms were noted in 10 (91 %), seven (81 %) children had manifestations of skin-mucosal and respiratory syndrome, more than half of children 6 (54 %) had manifestations of gastrointestinal disorders. Lymphopenia was observed in 9 (81 %), anemia in 8 (72 %), abnormal platelet levels in 5 (63 %), high activity of inflammatory markers (CRP, ferritin, ESR) in all children. Decreased ejection fraction according to ECHO data in 2 children, pericarditis in 10 (90 %) patients, aneurysmal and dilatational changes of coronary vessels were observed in two children. Glucocorticosteroid therapy was included in the treatment plan of all children, 8 (72 %) children each received human immunoglobulin and antiplatelet drugs, 9 (81 %) received antibacterial drugs, 3 (27 %) received anticoagulants, one child needed oxygen therapy using nasal cannulae. Complete clinical and laboratory recovery occurred in 100 % of patients.
Conclusions. The development of MIS in children due to previous contact with the SARS-CoV-2 virus can cause severe inflammatory changes in any organs and tissues. Comparing the obtained data of the observation group with European studies, it is necessary to note their practical identity according to clinical and laboratory characteristics.
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