MODERN APPROACHES TO PHARMACOTHERAPY IN CHILDREN
DOI:
https://doi.org/10.11603/24116-4944.2022.1.13254Keywords:
pain in children, opioid analgesics, non-opioid analgesics, pharmacology of analgesics, pharmacotherapy of painAbstract
The aim of the study – to summarize the latest available data on the clinical pharmacology of analgesics and pharmacocorrection of pain in children.
Materials and Methods. A bibliographic search for results of the study of the analgesics use for pain relief in children was conducted using PubMed EMBASE databases as the main search engines.
Results and Discussion. The main scales for assessing pain in children, adapted to those developed in the USA and Great Britain, are presented. Opioid analgesics are quite often used for acute pain, in particular, morphine at a dose of 50–200 μg/kg; methadone orally at a dose of 50–200 μg/kg; fentanyl (0.5–4 μg/kg); alfentanil (10–20 μg/kg); sufentanil (10–15 μg/kg) and remifentanil (5 μg/kg) intravenously. Short-acting opioid analgesics fentanyl, alfentanil, sufentanil, and remifentanil are used for very severe and unbearable pain. Non-opioid analgesics are prescribed for moderate pain. Paracetamol (acetaminophen at a dose of 12–15 mg/kg), midazolam (50–150 μg/kg), which is not recommended for newborns, and propafol (2.5 mg/kg) can be used.
Conclusions. In recent years, preference is given to non-opioid analgesics for non-acute pain relief in pediatric patients.
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