BIOREGULATORY AND IMMUNOLOGICAL FEATURES OF PREMATURE LABOR
DOI:
https://doi.org/10.11603/24116-4944.2022.1.13250Keywords:
premature birth, relaxin, interleukin-6Abstract
The aim of the study – to analyze the potential correlation between the level of the hormone relaxin in the mother’s serum and the increased risk of preterm birth, as well as to study the role of cytokines, including interleukin-6 (IL-6) in the development of this pathology.
Materials and Methods. A survey of 75 pregnant women was carried out, who were divided into 3 clinical groups. The main group consisted of 30 women with preterm labor at 35–37 weeks. The comparison group consisted of 35 pregnant women with the physiological course of the first stage of labor. The control group consisted of women with the physiological course of the third trimester of pregnancy. All pregnant women underwent anamnesis collection, complete clinical and laboratory examination, immunological studies, and studies of the level of relaxin were carried out by the method of enzyme-linked immunosorbent assay. Statistical processing of the obtained results was carried out on a personal computer using the STATISTICA-6 program.
Results and Discussion. A significant increase in the content of relaxin in pregnant women with preterm labor (p <0.05) and a significant increase in the level of IL-6 in pregnant women with preterm labor and especially in physiological term labor were found. The important biological role of the studied molecular biological parameters in the complex pathogenetic mechanism of the onset of labor has been determined.
Conclusions. The onset of preterm labor associated with an increase in the concentration of relaxin and pro-inflammatory myokines, in particular IL-6. The investigated factors can become reliable immunobiological markers of predictors of preterm labor.
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