VIOLATION OF VAGINAL ECOSYSTEM MICROBIOTA AND FEATURES OF THE STRUCTURAL PARAMETERS OF THE OVARIES IN PATIENTS WITH REPRODUCTIVE LOSSES IN EARLY PREGNANCY
DOI:
https://doi.org/10.11603/24116-4944.2022.1.13217Keywords:
miscarriage, endometrial dysfunction, microbiota of the vaginal ecosystem, structural components of ovarian tissue, chronic endometritis, ovarian reserveAbstract
The aim of the study is to evaluate the structural parameters of the ovaries and the state of the microbiocenosis of the vaginal mucosa in patients with uterine factors of infertility and reproductive losses.
Materials and methods. A retrospective study, analysis of medical records and evaluation of the microbiota of the vaginal ecosystem was conducted in 90 examined women with diagnosed intrauterine pathology and impaired reproductive function, among them with infertility (46.7%) and reproductive losses in history (53.3%).The control group included 30 practically healthy women who gave birth. Instrumental examination methods (ultrasound), dopplerometry, immunofermentic methods of ovarian reserve assessment, and statistical calculation methods were used.
Research results and their discussion. The following violations of normobiocenosis were established: severe dysbiosis by 5.8 times (p<0.05) in patients of the main group, etiological agents are Candida fungi and anaerobic microorganisms associated with bacterial vaginosis. The volume of the ovarian tissue tended to decrease, against the background of increased peripheral resistance of the ovarian vascular bed and decreased tissue blood flow. The established share of retention formations in the structure of morphological variants of benign ovarian tumors is more than a quarter. A high proportion of sonographic signs of chronic endometritis suggests the possibility of an inflammatory component in the genesis of implantation failure.
Conclusions. The risk of reproductive losses increases with the presence of an inflammatory component in the genesis of implantation failure.
References
Boichuk, A. V., Shadrina, V. S., & Vereshchahina, T. V. (2019). Hiperplaziia endometriia – suchasnyi systemno-patohenetychnyi pohliad na problemu (ohliad literatury) [Endometrial hyperplasia – a modern systemic-pathogenetic view of the problem (literature review)]. Aktualni pytannia pediatrii, akusherstva ta hinekolohii – Current issues of pediatrics, obstetrics and gynecology, 1, 67–72 [in Ukrainian].
Blesmanovych A.E., & Alekhyna, A.H., & Petrov, Yu.A. (2017). Besplodye kak sledstvye khronycheskoho vospalenyia slyzystoi obolochky matky [Infertility as a result of chronic inflammation of the uterine mucosa]. Mezhdunarodnyj zhurnal eksperimentalnogo obrazovaniya. Medicinskie nauki. – International Journal of Experimental Education. Medical Sciences, 4, 18– 21 [in Ukrainian].
Vovk I. B., Gorban, N.E., Lysyanaya, T.A., Netreba N.I., & Ponomareva, I.G. (2019). Rol vospalitelnogo faktora v geneze giperplasticheskih izmenenij endometriya u zhenshin reproduktivnogo vozrasta [The role of the inflammatory factor in the genesis of endometrial hyperplastic changes in women of reproductive age]. Aktualni pitannya pediatriyi, akusherstva ta ginekologiyi – Current issues of pediatrics, obstetrics and gynecology, 1, 73-80 [in Ukrainian].
Gorbatenko, N.V., Bezhenar, V.F., & Fishman, M.B. (2017).Vliyanie ozhireniya na razvitie narusheniya reproduktivnoj funkcii u zhenshin (analiticheskij obzor literatury) [Influence of obesity on the development of reproductive dysfunction in women (analytical review of the literature)]. Ozhirenie i metabolism – Obesity and metabolism, 1, 3-8 [in Ukrainian].
Gorban, N. Ye., Zadorozhna, T.D., Vovk, I.B., & Zhulkevich, I.V. (2019). Morfologichni osoblivosti polipiv tila matki u zhinok reproduktivnogo viku [Morphological features of uterine polyps in women of reproductive age].Visnik nauk. doslidzhen – Bulletin of Sciences. Research, 2(95), 47-52 [in Ukrainian].
Lisyana, T. O., Ponomarova, I.G., Kovalchuk, O.A., Kacalap, O.M., & Gorban, N.Ye. (2017). Harakteristika disbiotichnih porushen statevih shlyahiv u zhinok z giperplastichnimi procesami ta polipami endometriya [Characteristics of dysbiotic disorders of the genital tract in women with hyperplastic processes and endometrial polyps]. Svit medicini ta biologiyi – The world of medicine and biology, 4(62), 54-58 [in Ukrainian].
Nosenko, O. M. & Yurchenko, S.V. (2021). Osoblivosti imunnoyi reaktivnosti endometriya z neatipovoyu giperplaziyeyu u paciyentok iz bezpliddyam ta ozhirinnyam [Features of the immune reactivity of the endometrium with atypical hyperplasia in patients with infertility and obesity]. Aktualni pitannya pediatriyi, akusherstva ta ginekologiyi – Current issues of pediatrics, obstetrics and gynecology, 2, 119-124[in Ukrainian].
Peshikov, O.V. (2019). Vliyanie osobennostej stroeniya yaichnikov na razvitie akushersko-ginekologicheskoj patologii (obzor) [Influence of structural features of the ovaries on the development of obstetric and gynecological pathology (review)] Uralskij medicinskij zhurnal – Ural Medical Journal, 5, 101-107 [in Russian].
Rozhkovskaya, N.N. & Gladchuk, I.Z., & Aleksandrov. A.L. (2017). Vozmozhnosti kompleksnogo ultrazvukovogo obsledovaniya v dooperacionnoj diagnostike opuholevidnyh obrazovanij yaichnikov [Possibilities of complex ultrasound examination in preoperative diagnosis of ovarian tumors]. Zdorove zhenshiny – Women's health, 2, 22–24 [in Ukrainian].
Suhostavec, N. P. (2016). Placentarnaya disfunkciya u zhenshin s endometriomami v anamneze [Placental dysfunction in women with endometriomas in the anamnesis]. Zbirnik naukovih prac spivrobitnikiv NMAPO imeni P. L. Shupika – Collection of scientific works of employees of the P. L. Shupyk NMAPO, 27, 81-84 [in Ukrainian].
Suhanova, A.A., Egorov, M.Yu., Manzhura, E.P., & Pechura, N.S. (2015). Epidemiologicheskie osobennosti opuholej yaichnikov na sovremennom etape [Epidemiological features of ovarian tumors at the present stage]. Zdorove zhenshiny – Women's health, 89,141-144 [in Ukrainian].
Tkachenko, L. V., & Sviridova, N. I. (2016). Sovremennyj podhod k lecheniyu hronicheskogo endometrita u pacientok s giperplasticheskimi processami endometriya [Modern approach to the treatment of chronic endometritis in patients with endometrial hyperplastic processes]. Doktor.Ru. – Doktor.Ru.,7, 15–20 [in Ukrainian].
Chajka, G. V. Yaremchuk, L.V., & Karetna, A.O. (2017). Optimizaciya likuvannya ta reabilitaciyi reproduktivnoyi funkciyi zhinok z giperplaziyeyu endometriya na tli zapalnih zahvoryuvan organiv malogo tazu [Optimization of treatment and rehabilitation of the reproductive function of women with endometrial hyperplasia against the background of inflammatory diseases of the pelvic organs]. Visnik Vinnickogo nacionalnogo medichnogo universitetu – Bulletin of the Vinnytsia National Medical University, 1, part 2, (Vols. 1), (pp. 302-306) [in Ukrainian].
Sharifulin, E.M., & Sharifulin, M.A., & Suturina, L.V. (2017). Endometrialnye markery sindroma polikistoza yaichnikov (obzor literatury) [Endometrial markers of polycystic ovary syndrome (literature review)]. Acta Biomedica Scientifica – Acta Biomedica Scientifica, 5, part 2, (Vols. 2), (pp. 21-27) [in Ukrainian].
Ali Al Chami, & Ertan Saridogan (2017). Endometrial polyps and subfertility. The Journal of Obstetrics and Gynecology of India, 6, 3556–3359 [in India].
Doroshenko-Kravchyk M.V. (2020). Newest approaches to the diagnosis of hyperplastic processes in gynecology. Svit medicini ta biologiyi – The world of medicine and biology, 2 (72), 48-52[in Ukrainian].
Kitaya, K., & Matsubayashi, H., & Yamaguchi, K., & Nishiyama, R., & Takaya, Y., & Ishikawa, T., et al. (2016). Shronic endometritis: potential cause of infertility and obstetric and neonatal complications. Am. J. Reprod. Immunol, 75(1), 13-22.
Kitaya, K., & Takeuchi, T., & Mizuta, S., & Matsubayashi, H., & Ishikawa, T. (2018). Endometritis: new time, new concepts. Fertil Steril, 3, (Vols. 110), (pp. 344-350).
Njume Peter Nijkangetal (2019). Endometrial polyps: Pathogenesis, sequelae and treatment. SAGE Open Medicine. 7, 1–12.
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