CLINICAL AND DIAGNOSTIC ASPECTS OF THE STATE OF THE MUCOSAL ECOSYSTEM IN CASE OF RECURRENT BACTERIAL VAGINOSIS IN WOMEN OF REPRODUCTIVE AGE WITH EXO-ENDOCERVIСAL PATHOLOGY
DOI:
https://doi.org/10.11603/24116-4944.2022.1.13216Keywords:
bacterial vaginosis, exo-endocervical pathology, microbiota of the vaginal mucosaAbstract
The purpose of the study was to assess the prevalence and clinical picture of vaginal dysbiosis in women of reproductive age as an additional factor inducing exo-endocervical pathology, and to identify the main trigger mechanisms for the development of this pathology.
Materials and methods. 90 women of reproductive age with clinical and laboratory manifestations of bacterial vaginosis were included in the study; two groups were formed: 50 patients with verified exo-endocervical pathology (main group) and 40 patients with BV manifestations without cervical pathology (comparison group).
Research results and their discussion. When studying the etiological structure of vaginitis in the examined groups, a combination of urogenital candidiasis and bacterial vaginosis was revealed in more than half of the observations (57.8%); the proportion of recurrent bacterial vaginosis prevailed 2.0 times in patients with exo-endocervical pathology, and 2.1 times higher share of severe dysbiosis was revealed.
Conclusions. A 2.0 times higher proportion of recurrent bacterial vaginosis and urogenital candidiasis was found in patients with exo-endocervical pathology. The microbiota of the vaginal biotope in case of exo-endocervical pathology is characterized by a deficiency of lactobacilli (52.0%), their low concentration (42.0%), a high frequency of the release of enterococci (58.0%), and multicomponent associations (66.0%).
References
Ananeva, M. M. (2018). Etiologicheskie i patogeneticheskie aspekty nespecificheskogo bakterialnogo vaginoza [Etiological and pathogenetic aspects of non-specific bacterial vaginosis]. Zaporozhskij medicinskij zhurnal – Zaporizhzhya Medical Journal, 3 (108), (Vols. 20), (pp. 34–37) [in Ukrainian].
Vdovichenko, Yu. P., & Gopchuk, Sh. M. (2016). Bakterialnij vaginoz – monoterapiya kombinovanimi preparatami [Bacterial vaginosis - monotherapy with combined drugs]. Zdorove zhenshiny – Women's Health, 1, 32–36 [in Ukrainian].
Klimnyuk, S. I. & Mihajlishin, G. I., & Malanchuk, L. M. (2019). Mikrobiologichni osoblivosti bakterialnih vaginoziv u zhinok riznih vikovih kategorij ta shlyahi yih mikrobiologichnoyi korekciyi [Microbiological features of bacterial vaginosis in women of different age categories and ways of their microbiological correction. Zdobutki klinichnoyi i eksperimentalnoyi medicini. – Proceedings of clinical and experimental medicine, 3, 21-31[in Ukrainian].
Lusta, M. V. (2018). Femoflor skrin yak metod diagnostiki disbakteriozu urogenitalnogo traktu zhinok reproduktivnogo viku [Femoflor screen as a method of diagnosing dysbacteriosis of the urogenital tract of women of reproductive age]. Hist : vseukrayinskij medichnij zhurnal molodih vchenih – Hist: All-Ukrainian medical journal of young scientists, 20, 212 [in Ukrainian].
Malanchuk, L. M. & Malanchuk, S. L., & Nebeso, T. A. (2016). Vaginalna mikrobiota: yak vidnoviti balans pri disbiozi [Vaginal microbiota: how to restore balance in dysbiosis]. Zdorove zhenshiny – Women's Health, 2, 107–111[in Ukrainian].
Nosenko, O. M. (2016). Suchasnij poglyad na cervikovaginalnij disbioz, viklikanij poyednannyam bakterialnogo vaginozu, asocijovanih bakterij ta drizhdzhopodibnih gribiv rodu Candida (oglyad literaturi ta vlasni dani) [Modern view of cervicovaginal dysbiosis caused by a combination of bacterial vaginosis, associated bacteria and yeast-like fungi of the genus Candida (literature review and own data)]. Zdorove zhenshiny – Women's Health, 7(153), 74–83 [in Ukrainian].
Parubina, D. Yu. (2018). Osoblivosti zaproponovanogo algoritmu vedennya paciyentok reproduktivnogo viku, hvorih na lejomiomu matki z riznim tipom biocenozu pihvi, ta ocinka jogo efektivnosti [Peculiarities of the proposed management algorithm for women of reproductive age, patients with uterine leiomyoma with different types of vaginal biocenosis, and evaluation of its effectiveness]. Odeskij medichnij zhurnal – Odesa Medical Journal, 2, 39–43[in Ukrainian].
Pirogova, V. I., & Malachinska, M. J., & Shurpyak, S. O., & Shuruk, N. V. (2015). Mikroekologiya pihvi – sho potribno znati akusheru-ginekologu (klinichna lekciya) [Microecology of the vagina - what an obstetrician-gynecologist needs to know (clinical lecture)]. Zdorove zhenshiny – Health of women, 7, 8–13 [in Ukrainian].
Tatarchuk, T. F. Sovremennyj podhod k terapii nespecificheskih vaginitov (obzor konferencii) [Modern approach to therapy of non-specific vaginitis (overview of the conference]. Zdorove zhenshiny – Health of women, 7, 126–129 [in Ukrainian].
Tertishnik, A. O. (2016). Stan mikrobiocenozu pihvi u paciyentok z nespecifichnim hronichnim salpigooforitom [The state of vaginal microbiocenosis in patients with nonspecific chronic salpygoophoritis]. Neonatologiya, hirurgiya ta perinatalna medicina – Neonatology, surgery and perinatal medicine, 1(19), (Vols. 6), (pp. 23–27) [in Ukrainian].
Zheng, J.J., Song, J.H., Yu, C.X., Wang, F., Wang, P.C., & Meng, J.W. (2019). Difference in vaginal microecology, local immunity and HPV infection among childbearing-age women with different degrees of cervical lesions in Inner Mongolia. BMC Womens Health.,19(1):109. Published 2019 Aug 12. doi:10.1186/s12905-019-0806-2
Zhang, Z., Li, T., & Zhang, D., et al. (2021). Distinction between vaginal and cervical microbiota in high-risk human papilloma virus-infected women in China. BMC Microbiol., 21(1), 90. Published 2021 Mar 25. doi:10.1186/s12866-021-02152-y
Letarov, A.V., Golomidova, A.K., & Tarasyan, K.K. (2010). Ecological basis for rational phage therapy. Acta Naturae., 2(1), 60-72.
Liang,Y., Chen, M., Qin, L., Wan, B., & Wang, H. A (2019). Meta-analysis of the relationship between vaginal microecology, human papillomavirus infection and cervical intraepithelial neoplasia. Infect Agent Cancer. Oct 26;14:29. doi: 10.1186/s13027-019-0243-8. Erratum in: Infect Agent Cancer. 2019 Dec 9;14:47. PMID: 31673281; PMCID: PMC6815368.
Li, D., Chi, X.Z., & Zhang, L., et al. (2020). Vaginal microbiome analysis of healthy women during different periods of gestation [published correction appears in Biosci Rep. 2020 Sep 30;40(9):]. Biosci Rep., 40(7):BSR20201766. doi:10.1042/BSR20201766
Lin, W., Zhang, Q., & Chen, Y., et al. (2022). Changes of the vaginal microbiota in HPV infection and cervical intraepithelial neoplasia: a cross-sectional analysis. Sci Rep.,12(1):2812. Published 2022 Feb 18. doi:10.1038/s41598-022-06731-5.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Actual Problems of Pediatrics, Obstetrics and Gynecology
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish in this journal agree to the following terms:
1. The authors reserve the right to authorship of the work and pass the journal right of first publication of this work is licensed under a Creative Commons Attribution License, which allows others to freely distribute the work published with reference to the authors of the original work and the first publication of this magazine.
2. Authors are entitled to enter into a separate agreement on additional non-exclusive distribution of work in the form in which it was published in the magazine (eg work place in the electronic repository institution or publish monographs in part), provided that the reference to the first publication of this magazine.
3. Policy magazine allows and encourages authors placement on the Internet (eg, in storage facilities or on personal websites) manuscript of how to submit the manuscript to the editor and during his editorial processing, since it contributes to productive scientific discussion and positive impact on the efficiency and dynamics of citing published work (see. The Effect of Open Access).
