CLINICAL FEATURES OF COVID–19 IN CHILDREN

Authors

DOI:

https://doi.org/10.11603/24116-4944.2021.2.12889

Keywords:

COVID-19, clinical specifics, children

Abstract

The aim of the study – to analyze the clinical and laboratory features of COVID–19 in children of different ages.

Materials and Methods. The clinical course of COVID-19 in 175 children aged 1 month to 18 years was retrospectively evaluated. To assess the clinical course of the disease, patients were divided into groups depending on age, while assessing the concomitant comorbid pathology, clinical and laboratory features of the disease, the duration of inpatient treatment. In the statistical analysis, 95 % confidence interval (95 % CI) was calculated for the mean values and Pearson’s criterion for the comparative analysis of frequency tables.

Results and Discussion. It was found that the largest group of children with COVID–19 were children aged 1–5. The most common symptoms in all children were fever ≥38.5 ° C, cough, nasal congestion and discharge, sore throat, and gastrointestinal disturbances in infants under 1 year of age, and asthenic syndrome in children ≥10 years of age. Based on clinical, laboratory and instrumental data, 139 children (79.4 %) were diagnosed with a mild course, 24 children (13.7 %) – moderate, and 12 children (6.9 %) – severe.

Conclusions. Children of all ages may have COVID–19 with the leading symptoms of respiratory viral infection, with a predominance of mild disease in infants <1 year of age and moderate to severe in children over 15 years of age.

Author Biographies

H. A. Pavlyshyn, I. Horbachevsky Ternopil National Medical University

I. Horbachevsky Ternopil National Medical University, MD, Professor, Head of Pediatrics Department No. 2

O. V. Labivka, I. Horbachevsky Ternopil National Medical University

I. Horbachevsky Ternopil National Medical University, postgraduate of Pediatrics Department No. 2

References

Panchenko, O.A., & Zavarzina, A.R. (2020). Diahnostyka koronavirusnoi infektsii yak aktualna problema derzhavnoho rivnia [Diagnosis of coronavirus infection as an urgent problem at the state level]. Ukrainskyi zhurnal medytsyny, biolohii ta sportu – Ukrainian Journal of Medicine, Biology and Sports, 5, 278-284 [in Ukrainian].

Ponti, G., Maccaferri, M., Ruini, C., Tomasi, A., & Ozben, T. (2020). Biomarkers associated with COVID–19 disease progression. Critical Reviews in Clinical Laboratory Science, 57 (6), 389-399.

Blanchard–Rohner, G., Didierlaurent, A., Tilmanne, A., Smeesters, P., & Marchant, A. (2021). Pediatric COVID–19: Immunopathogenesis, Transmission and Prevention. Vaccines, 9, 1002.

Zhonghua, Er Ke Za Zhi. (2020). Recommendations for the diagnosis, prevention and control of the 2019 novel coronavirus infection in children (first interim edition). Chinese Journal of Pediatrics, 58, 169-174.

Wu, Z., & Googan, J.M. (2020). Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID–19) Outbreak in China. JAMA, 323, 1239-1242.

Livingston, Е., & Bucher, K. (2020). Coronavirus Disease 2019 (COVID–19) in Italy. JAMA, 323, 236-249.

CDC COVID–19 Response Team. (2020). Coronavirus disease 2019 in children of United States. Morb. Mortal Wkly. Rep., 69, 422-426.

Castagnoli, R., Votto, M., & Licari, A. (2020). Severe acute respiratory syndrome coronavirus 2 (SARS–CoV–2) infection in children and adolescents: a systematic review. JAMA Pediatr., 174, 882-889.

Midulla, F., Cristiani, L., & Mancino, F. Will children reveal their secret? The coronavirus dilemma. Eur. Respir. J., 55, 2000749.

Cao, Q., & Chen, Yi–C. SARS–CoV–2 infection in children: Transmission dynamics and clinical characteristics. Journal of the Formosan Medical Association, 119 (3), 670-673.

Dong, Y., Mo, Xi., Hu, Y., Qi, X., Jiang, F., Jiang, Z., et al. (2020). Epidemiology of COVID–19 Among Children in China. Pediatrics, 145 (6), e20200702.

Lu, X., Zhang, L., Du, H., Zhang, J., Li, Y., Qu, J. et al. (2020). SARS–CoV–2 Infection in Children. N. Engl. J. Med., 382, 1663-1665.

Posfay–Barbe, K., Wagner, N., Gauthey, M., Moussaoui, D., Loevy, N., Diana, A., et al. (2020). COVID–19 in children and the dynamics of infection in families. Pediatrics, 146 (2), e20201576.

Duarte–Salles, T., Vizcaya, D., Pistillo, A., Casajust, P., Sena, A., Yin Hui Lai, L., et all. ( 2020). Baseline Characteristics, Management, and Outcomes of 55,270 Children and Adolescents Diagnosed with COVID–19 and 1,952,693 with Influenza in France, Germany, Spain, South Korea and the United States: An International Network Cohort Study. Medrxiv, 33140074.

Wong, B., Ramsay, M., & Ladhani, S. (2021). Should children be vaccinated against COVID–19 now? Arch Dis Child, 106 (12), 1147-1148.

Dong, Y., Mo, X., Hu, Y., Qi, X., Jiang, F., & Jiang, Z. Epidemiological characteristics of 2143 pediatric patients with 2019 coronavirus disease in China. Pediatrics, 58 (4), 712-713.

Vabret, A., Mourez, T., Gouarin, S., Petitjean, J., & Freymuth, F. (2003). An outbreak of coronavirus OC43 respiratory infection in Normandy, France. Clin. Infect. Dis., 36, 985-989.

S. Chiu, S., Chan, K.H., Chu, K.W., Kwan, S.W., Guan, Yi., Poon, L., et al. (2005). Human coronavirus NL63 infection and other coronavirus infections in children hospitalized with acute respiratory disease in Hong Kong. Clin. Infect. Dis., 40, 1721-1729.

Uddin, S., , Englund, J., Kuypers, J., Chu, H., Steinhoff, M., Khatry, S., et all. (2018). Burden and risk factors for coronavirus infections in infants in rural Nepal. Clin. Infect. Dis., 67, 1507-1514.

Viner, R., Ward, J., & Hudson, L. (2021). Systematic review of reviews of symptoms and signs of COVID–19 in children and adolescents. Arch. Dis. Child., 106, 802-807.

Zhonghua, E. (2020). Recommendations for the diagnosis, prevention and control of the 2019 novel coronavirus infection in children (first interim edition). Chinese Journal of Pediatrics, 58, 169-174.

Cheng, F., Ng, P., Chiu, W., Chu, W., Li, A., Lo, K., et al. (2005). A case–control study of SARS versus community acquired pneumonia. Arch. Dis. Child, 90, 747-749.

Hon, K., Leung, C., Cheng, W., Chan, P., Chu, W., Kwan, Y., et al. (2003). Clinical presentations and outcome of severe acute respiratory syndrome in children. Lancet, 361, 1701–1703.

Leung, C., Kwan, Y., Ko, P., S. Chiu, S., Loung, P., Fong, N., et al. (2003). Severe acute respiratory syndrome in children: experience in a regional hospital in Hong Kong. Pediatr Crit Care Med., 4, 279-283.

Bitnun, A., Allen, U., Heurter, H., M. King, S., Opavsky, M.A.L., Ford–Jones, E., et all. (2003). Children hospitalized with severe acute respiratory syndrome–related illness in Toronto . Pediatrics, 112, 261-268.

Chen, Z–M., Fu, J–F., Shu, Q., Chen, Y–H., Hua, C–Z., Li, F–B., et al. (2020). Diagnosis and treatment recommendations for pediatric respiratory infection caused by the 2019 novel coronavirus. World J. Pediatr., 16, 240-246.

Leung, C., Kwan, Y., Ko, P., Susan, S. Chiu., P, Loung., et al. (2004). Severe acute respiratory syndrome among children. Pediatrics, 113, 535-543.

Zimmermann, P., & Curtis, N. (2020). Coronavirus Infections in Children Including COVID–19. The Pediatric Infectious Disease Journal, 39 (5), 355-368.

Götzinger, F., Santiago–García, B., Noguera–Julián, A., Lanaspa, M., Lancella, L., Calò Carducci, F.I., et al. (2020). COVID–19 in children and adolescents in Europe: A Multinational, Multicentre Cohort Study. Lancet Child Adolesc. Health, 4, 653-661.

Cao, Q., & Chen, Y–C. (2020). SARS–CoV–2 infection in children: Transmission dynamics and clinical characteristics. J. Formos Med. Assoc., 119, 670-673.

Published

2022-05-04

How to Cite

Pavlyshyn, H. A., & Labivka, O. V. (2022). CLINICAL FEATURES OF COVID–19 IN CHILDREN. Actual Problems of Pediatrics, Obstetrics and Gynecology, (2), 25–31. https://doi.org/10.11603/24116-4944.2021.2.12889

Issue

Section

PEDIATRICS