MENSTRUAL DYSFUNCTION IN ADOLESCENT GIRLS ASSOCIATED WITH METABOLIC SYNDROME (LITERATURE REVIEW)

(LITERATURE REVIEW)

Authors

DOI:

https://doi.org/10.11603/24116-4944.2021.2.12887

Keywords:

metabolic syndrome, obesity, menstrual disorders, reproductive health of adolescents

Abstract

The aim of the study – to determine the frequency and structure of gynecological morbidity and menstrual disorders in adolescent girls associated with metabolic syndrome. The role of adipose tissue in the regulation of the menstrual cycle as one of the hormone-producing organs has been proven. Disorders in the hypothalamic-pituitary-ovarian complex against the background of the metabolic syndrome manifest as symptoms of dysfunction of the reproductive system. In addition, there is a correlation between body mass index and the severity of menstrual dysfunction.

Conclusions. Gynecological morbidity in adolescent girls with metabolic syndrome is characterized by an increase in the frequency of menstrual irregularities in 21–33 % of cases, manifested as dysmenorrhea, abnormal uterine bleeding, luteal phase insufficiency, anovulation, infertility, oligomenorrhea – 60 %, amenorrhea in 28.3 %, uterine bleeding – in 48.3 %. These girls develop proliferative processes in the endometrium against the background of chronic anovulation. However, early detection and correction of metabolic and menstrual disorders can have a significant impact on the prognosis and consequences of the metabolic syndrome for the health of girls.

Author Biographies

A. A. Sinkina, Sumy State University

Associate Professor of Obstetrics, Gynecology and Family Planning, Sumy State University

I. M. Nikitina, Sumy State University

Doctor of Medical Sciences, Associate Professor of Obstetrics, Gynecology and Family Planning, Sumy State University

References

Tronko, M.D. (2019). Vyklyky ta realii suchasnoi endokrynolohichnoi sluzhby: fundamentalna ta prykladna nauka v klinichnii endokrynolohii [Challenges and realities of modern endocrinology service: basic and applied science in clinical endocrinology]. Zdorovia Ukrainy – Health of Ukraine, 46 (2), 24-26 [in Ukrainian].

Zelinska, N.B. (2013). Metabolichnyi syndrom u ditei [Metabolic syndrome in children] Zdorovia Ukrainy – Health of Ukraine, 6, 48-51 [in Ukrainian].

Reinehr, T., de Sousa, G., Toschke, A.M., & Andler, W. (2007). Comparison of metabolic syndrome prevalence using eight different definitions: a critical approach. Arch. Dis. Child., 92 (12), 1067-1072. DOI: 10.1136/adc.2006.104588.

Bohler, H.Jr., Mokshagundam, S., & Winters, S.J. (2010). Adipose tissue and reproduction in women. Fertil. Steril., 94 (3), 795-825. DOI: 10.1016/j.fertnstert.2009.03.079.

The ESHRE Capri Workshop Group (2006). Nutrition and reproduction in women. Hum. Reprod. Update, 12 (3), 193-207. DOI: 10.1093/humupd/dmk003.

Fischer-Posovszky, P., Roos, J., Kotnik, P., Battelino, T., Inzaghi, E., Nobili, V., …, & Wabitsch, M. (2016). Functional significance and predictive value of micro-RNAs in pediatric obesity: tiny molecules with huge impact? Horm. Res. Paediatr., 86 (1), 3-10. DOI: 10.1159/000444677.

Elias C.F., Purohit D. (2013). Leptin signaling and circuits in puberty and fertility. Cell Mol. Life Sci., 70 (5), 841-862. DOI: 10.1007/s00018-012-1095-1.

Moran, L.J., Norman, R.J., & Teede, H.J. (2015). Metabolic risk in PCOS: phenotype and adiposity impact. Trends Endocrinol. Metab., 26 (3), 136-143. DOI: 10.1016/j.tem.2014.12.003.

Brewer, C.J., & Balen, A.H. (2010). The adverse effects of obesity on conception and implantation. Reproduction, 140 (3), 347-364. DOI: 10.1530/REP-09-0568.

Voronenko, N.Iu. (2013). Sotsialno-psykholohichni osoblyvosti zdorovia zhinok iz metabolichnym syndromom [Socio-psychological features of the health of women with metabolic syndrome] Ukr. Med. Chasopys – Ukrainian Medical Journal, 3 (95), 146-149 [in Ukrainian].

Zelinska, N.B. (2013). Ozhyrinnia ta metabolichnyi syndrom u ditei [Obesity and metabolic syndrome in children]. Klinichna endokrynolohiia ta endokrynolohichna khirurhiia – Clin. Endocrinol. Endocr. Surg., 4 (45), 62-72 [in Ukrainian].

Fleming, R., Hopkinson, Z.E., Wallace, A.M., Greer, I.A., & Sattar, N. (2002). Ovarian function and metabolic factors in women with oligomenorrhea treated with metformin in a randomized double blind placebo-controlled trial. J. Clin. Endocrinol. Metab., 87 (2), 569-574. DOI: 10.1210/jcem.87.2.8261.

Kuneš, J., Vaněčková, I., Mikulášková, B., Behuliak, M., Maletínská, L., & Zicha, J. (2015). Epigenetics and a New look on metabolic syndrome. Physiol. Res., 64 (5), 611-620. DOI: 10.33549/physiolres.933174.

Ross, M.G., & Desai, M. (2013). Developmental programming of offspring obesity, adipogenesis, and appetite. Clin. Obstet. Gynecol., 56 (3), 529-536. DOI: 10.1097/GRF.0b013e318299c39d.

Tatarchuk, T.F., Kosei, N.V., Reheda, S.I., Tutchenko, T.M., & Hlamazda, M.I. (2019). Rol porushen reproduktyvnoho zdorovia v rozvytku metabolichnoho syndromu u zhinok [The role of reproductive health disorders in the development of metabolic syndrome in women]. Zhurnal Natsionalnoi akademii medychnykh nauk Ukrainy – National Academy of Medical Sciences of Ukraine Journal, 25 (1), 77-87 [in Ukrainian].

De Lorenzo, A., Soldati, L., Sarlo, F., Calvani, M., Di Lorenzo, N., & Di Renzo, L. (2016). New obesity classifcation criteria as a tool for bariatric surgery indication. World J. Gastroenterol., 22 (2), 681-703. DOI: 10.3748/wjg.v22.i2.681.

Beloded, O.A. (2018). Syndrom polykystoznykh yaychnykov [Polycystic ovary syndrome]. Upravlenye ryskamy – Risk Management, 4 (78), 8-14 [in Russian].

Pacifico, L., Anania, C., Martino, F., Poggiogalle, E., Chiarelli, F., Arca, M., & Chiesa, C. (2011). Management of metabolic syndrome in children and adolescents. Nutr. Metab. Cardiovasc. Dis., 21 (6), 455-466. DOI: 10.1016/j.numecd.2011.01.011.

Royall, D., Brauer, P., Bjorklund, L., O'Young, O., Tremblay, A., Jeejeebhoy, K., …, & Mutch, D.M. (2014). Development of a dietary management care map for metabolic syndrome. Can. J. Diet. Pract. Res., 75 (3), 132-139. DOI: 10.3148/cjdpr-2014-005.

Pedachenko (Voronenko), N.Yu. (2013). Klynycheskaya kharakterystyka zhenshchyn reproduktyvnogo vozrasta s metabolycheskym syndromom [Clinical characteristics of women of reproductive age with metabolic syndrome]. Medytsyna – Medicine, 4 (83), 37-46 [in Russian].

Pedachenko, N.Yu. (2010). Stan reproduktyvnoi systemy pry metabolichnomu syndromi [The state of the reproductive system in metabolic syndrome]. Zdorovia zhinky – Women's Health, 8 (54), 136-139 [in Ukrainian].

Zabolotna, I.E., & Yashchenko, L.V. (2019). Ozhyrinnia ta nadmirna masa tila v ditei, kryterii diahnostyky ta statystyka [Obesity and overweight in children, diagnostic criteria and prevalence statistics]. Klinichna ta profilaktychna medytsyna – Clinical and preventive medicine, 8 (2), 36-46 [in Ukrainian].

Bentsa, T.M., & Fohel, E.A. (2013). Sovremennye metody dyahnostyky metabolycheskoho syndroma [Modern methods for diagnosing metabolic syndrome]. Praktycheskaia anhyolohyia – Practical Anchiology, 7-8, 18-19 [in Russian].

Sorokman, T.V., Popeliuk, O.M.V., & Makarova, O.V. (2017). Znyzhennia masy tila – narizhnyi kamin terapii metabolichnoho syndromu v pidlitkiv [Weight loss is a cornerstone of the treatment of metabolic syndrome in adolescents]. Mizhnarodnyi endokrynolohichnyi zhurnal – International Journal of Endocrinology, 13 (2), 108-113 [in Ukrainian].

Li, Y.Q., Cao, X.X., Bai, B., Zhang, J.N., Wang, M.Q., & Zhang, Y.H. (2013). Severe iron deficiency is associated with a reduced conception rate in femalerats. Gynecol. Obstet. Invest., 77 (1), 19-23. DOI: 10.1159/000355112.

Pankiv, I.V., & Povorozniuk, V.V. (2019). Stan zabezpechennia vitaminom D naselennia Zakhidnoho rehionu Ukrainy [The state of vitamin D supply in the population of the Western region of Ukraine]. Mizhnarodnyi endokrynolohichnyi zhurnal – International Journal of Endocrinology, 3, 268-371 [in Ukrainian].

Spiro, A., & Buttriss, J.L. (2014). Vitamin D: An overview of vitamin D status and intake in Europe. Nutr. Bull., 39 (4), 322-350. DOI: 10.1111/nbu.12108.

Cheng, L. (2018). The convergence of two epidemics: vitamin D deficiency in obese school-aged children. J. Pediatr. Nurs., 38, 206. DOI: 10.1016/j.pedn.2017.10.005.

Pavlyshyn, H.A., & Shulhai, A.-M.A. (2021). Zabezpechennist vitaminom D i metabolichnyi syndrom u ditei pidlitkovoho viku z ozhyrinniam [Vitamin D supplementation and metabolic syndrome in obese adolescents]. Aktualni pytannia pediatrii, akusherstva ta hinekolohii – Actual Problems of Pediatrics, Obstetrics and Gynecology, 1, 12-19 [in Ukrainian].

Published

2022-05-03

How to Cite

Sinkina, A. A., & Nikitina, I. M. (2022). MENSTRUAL DYSFUNCTION IN ADOLESCENT GIRLS ASSOCIATED WITH METABOLIC SYNDROME (LITERATURE REVIEW): (LITERATURE REVIEW). Actual Problems of Pediatrics, Obstetrics and Gynecology, (2), 114–119. https://doi.org/10.11603/24116-4944.2021.2.12887

Issue

Section

OBSTETRICS AND GYNECOLOGY