COMPLEX THERAPY OF MENSTRUAL DYSFUNCTION IN REPRODUCTIVE AGE WOMEN WITH METABOLIC SYNDROME

Authors

  • Л. Є. Лимар I. Horbachevsky Ternopil National Medical University
  • Н. А. Лимар Municipal Institution “Mother and Child", Ternopil
  • І. М. Malanchyn I. Horbachevsky Ternopil National Medical University
  • В. М. Мартинюк I. Horbachevsky Ternopil National Medical University

DOI:

https://doi.org/10.11603/24116-4944.2021.2.12884

Keywords:

menstrual dysfunction, metabolic syndrome, inositol

Abstract

The aim of the study – to find the impact of complex therapy with vicarious inositols on menstrual function in women with MD and MS.

Materials and Methods. 76 women of reproductive age (aged 18–43) were treated with MD and MS: oligomenorrhea and dysmenorrhea. The control group had 30 women with MD without MS. The manifestations of MD were studied, the level of protein fractions, cholesterol, transaminases in MS was determined.

Results and Discussion. Patients were divided into 2 groups according to the method of treatment. A significant decrease in albumin, an increase in cholesterol, transaminases, and high indicators of BMI were revealed. The results are confirmed by literary data. The women of both groups feared obesity to the point of exultation. The use of inositol in complex therapy led to a significant decrease in cholesterol, transaminases, and albumin elevation. In group 2, the BMI decreased to a normal level. The obtained results correspond to the literature data.

Conclusions. In women of reproductive age with MS, menstrual dysfunction is observed, namely: oligomenorrhea and dysmenorrhea. In women with MD and MS, there is an increase in the level of cholesterol, ALT, AST, GGT in blood, which is evidence of impaired liver function. Complex therapy with vicarious inositol ensures a decrease in BMI to 25.0 kg/m2. In 65.9 % of women, and in 90.2 % of women, it restores a normal menstrual cycle.

Author Biographies

Л. Є. Лимар, I. Horbachevsky Ternopil National Medical University

I. Horbachevsky Ternopil National Medical University, PhD (Medicine), Associate Professor of the Department of Obstetrics and Gynecology No. 1

Н. А. Лимар, Municipal Institution “Mother and Child", Ternopil

Municipal Institution “Mother and Child", Ternopil, PhD (Medicine), obstetrician-gynecologist, resident of the branch of Municipal Institution “Mother and Child", Ternopil

І. М. Malanchyn, I. Horbachevsky Ternopil National Medical University

PhD (Medicine), Associate Professor of the Department of Obstetrics and Gynecology No.1

 

В. М. Мартинюк, I. Horbachevsky Ternopil National Medical University

PhD (Medicine), Assistant of the Department of Obstetrics and Gynecology

References

Dyndar, O.A. (2019). Osoblyvosti metabolichnykh i hormonalnykh porushen u zhinok z metabolichnym syndromom na prehravidarnomu etapi [Features of metabolic and hormonal disorders in women with metabolic syndrome at the pre-pregnancy stage]. Hinekolohiia, akusherstvo, reproduktolohiya – Gynecol. Obstet. Reprod., 1 (33), 10 [in Ukrainian].

Legro, R., & Arslanian, S. (2014). Klinicheskoe prakticheskoe rukovodstvo odshchestva endokrinologov SSHA “Diagnostika i lechenie sindroma polikistosnykh iaichnikov” [Clinical practical guide to the US Society of Endocrinologists "Diagnosis and treatment of polycystic ovary syndrome"]. Kyiv [in Russian].

Lymar, L.E., & Lymar, N.A. (2015). Deiaki aspekty patohenezu rozladiv menstrualnoi funktsii pry khronichnykh hepatytakh [Some aspects of the pathogenesis of menstrual dysfunction in chronic hepatitis]. Aktualni pytannia pediatrii, akusherstva ta hinekolohii – Current Issues of Pediatrics, Obstetrics and Gynecology, 1, 145-148 [in Ukrainian].

Manukhin, I.B., Tumilovich, L.G., & Gevorkyan, M.A. (2014). Gynekologicheskaya endokrinologiya: klinicheskie lektsii, 3-e izdanie. Pererabotannoe [Gynecological endocrinology: clinical lectures. 3rd ed.]. Moscow: GEOTAR Media [in Russian].

Milevskaya, N.V. (2017). Amenoreya u divchat-pidlitkiv: prychyny, diahnostyka [Amenorrhea in teenage girls: causes, diagnosis]. Zhinochyi likar – Female Doctor, 1 (69), 60-63 [in Ukrainian].

Kaminskyy, V.V., Tatarchuk, T.F., & Dubossarska, Yu.O. (2016). Natsionalnyi konsensus shchodo vedennia patsiientok iz hiperandroheniieiu [National consensus on the management of patients with hyperandrogenism]. Kyiv [in Ukrainian].

Semenina G. B. (2016). Endokrynni ta obminno-metabolichni porushennya v zhinok iz syndromom polikistoznykh yayechnykiv i novi mozhlyvosti yikhnioyi korektsiyi [Endocrine and metabolic disorders in women with polycystic ovary syndrome and new possibilities for their correction]. Reproduktyvna endokrynolohiia – Reproductive Endocrinology, 6, 15-17 [in Ukrainian].

Tatarchuk, T.F. (2013). Reproduktyvnoe zdorove zhenshchyny v 21 veke [Reproductive health of women in the XXI century]. Z turbotoiu pro zhinku – With Care for a Woman, 8 (47), 6-8[in Ukrainian].

Kapshuk, I. M., & Islamova, H. O. (2018.) Osoblyvosti likuvannia syndromu polikistoznykh yaiechnykiv u zhinok z metabolichnym syndromom [Features of treatment of polycystic ovary syndrome in women with metabolic syndrome]. Slovo pro zdorovia – A word about health, 1 (13), 32-36. [in Ukrainian].

Kalugina, L.V., & Yusko, T.I. (2018). Mio-inozitol: terapevticheskiye vozmozhnosti i pregravidarnaya podgotovka pri sindrome polikistoznykh yaichnikov (obzor literatury) [Myo-inositol: therapeutic capabilities and pre-pregnancy training in polycystic ovary syndrome (literature review)]. Reproduktivna endokrinologiya – Reproductive Endocrinology, 4 (42), 40-45 [in Russian].

Gromova, O.A., Torshin, I.Yu., & Limanova, O.A. (2013). Perspektivy ispolzovaniya mio-inozitola u zhenshchn s polikistozom yaichnikov i insulinorezistentnostiu v programmakh podgotovki k ekstrakorporalnomu oplodotvoreniiu [Prospects for the use of myo-inositol in women with polycystic ovaries and insulin resistance in preparation programs for in vitro fertilization]. Effektivnaya farmakoterapiya – Effective Pharmacotherapy, 5 (51) [in Ukrainian].

March, W.A., Moore, V.M., Willson, K.J., Phillips, D.I., Norman, R.J., & Davies, M.J. (2010). The prevalence of polycystic ovary syndrome in community sample assessed under contrasting diagnostic criteria. Hum. Reprod., 25 (2), 544 551.

Schinder, A.E. (2013). Nekontratseptivnyye polozhitelnyye effekty kombinirovannykh oralnykh kontratseptivov [Non-contraceptive positive effects of combined oral contraceptives]. Int. J. Endocrinol. Metab., 11, 41-47 [in Russian].

Corwey G., Dewailly D., Diamanti-Kandarakis E. (2014). Ofitsialnoye zayavleniye Yevropeyskogo obshchestva endokrinologii «Sindrom polikistoznykh yaichnikov» [The official statement of the European Society of Endocrinology "Polycystic ovary syndrome"]. Eur. J. Endocrinol., 171, 1-29 [in Russian].

Published

2022-05-03

How to Cite

Лимар, Л. Є., Лимар, Н. А., Malanchyn І. М., & Мартинюк, В. М. (2022). COMPLEX THERAPY OF MENSTRUAL DYSFUNCTION IN REPRODUCTIVE AGE WOMEN WITH METABOLIC SYNDROME . Actual Problems of Pediatrics, Obstetrics and Gynecology, (2), 82–85. https://doi.org/10.11603/24116-4944.2021.2.12884

Issue

Section

OBSTETRICS AND GYNECOLOGY