EFFECT OF COVID-19 ON MEN'S REPRODUCTIVE FUNCTION

Authors

DOI:

https://doi.org/10.11603/24116-4944.2021.2.12679

Keywords:

COVID-19, male reproductive function, ejaculate, spermogram parameters

Abstract

The aim of the study – to analyze the changes in spermogram of men who became ill with COVID-19.

Materials and Methods. 46 men aged 20–60 were examined. Spermogram parameters before the disease, 14–30 and 60–90 days after the disease were determined. These indicators were determined according to the guidelines of the "Laboratory study of ejaculate", compiled in accordance with the Guidelines of the World Health Organization for the study and treatment of human ejaculate (1999).

Results and Discussion. 14–30 days after the disease, a decrease in the concentration and total number of sperm, total sperm motility, living and morphologically normal spermatozoa was detected. 60–90 days after COVID-19 transfer, sperm counts improved. Qualitative and quantitative deterioration of ejaculate was observed in men aged 20–40; in patients aged 40–60, no changes in sperm counts were detected.

Conclusions. Transfer of COVID-19 adversely affects the qualitative and quantitative parameters of ejaculate, but after 2–3 months these indicators improved. Deterioration was observed only in men aged 20–40 years, while in older patients (40–60 years) no such changes were detected.

Author Biographies

S. V. Khmil, I. Horbachevsky Ternopil State Medical University, Medical Center «Professor Stefan Khmil Clinic»

MD, PhD, DSci, Professor, Merited figure of Science and Technology of Ukraine, Professor of the Department of Obstetrics and Gynecology No. 1 I. Horbachevsky Ternopil National Medical University, director of Medical Center «Professor Stefan Khmil Clinic»

O. Yu. Mayorova, I. Horbachevsky Ternopil State Medical University, Medical Center «Professor Stefan Khmil Clinic»

Ph.D., Teacher of the Botany and Zoology Department, Ternopil Volodymyr Hnatiuk National Pedagogical University, Biologist of  Medical Center «Clinic of Prof. Stefan Khmil»

M. S. Khmil, I. Horbachevsky Ternopil State Medical University, Medical Center «Professor Stefan Khmil Clinic»

Ph.D., Assistant of the Department of Obstetrics and Gynecology № 1, I. Horbachevsky Ternopil National Medical University, medical director of the Medical Center «Clinic of Professor S. Khmil» 

I. V. Chorna, Medical Center «Professor Stefan Khmil Clinic»

biologist of Medical Center «Clinic of Professor S. Khmil»

References

Guan, W.J., Ni, Z.Y., Hu, Y., Liang, W.H., Ou, C.Q., He, J.X., …, & Zhong, N.S. (2020). Clinical characteristics of coronavirus disease 2019 in China. N. Engl. J. Med., 382 (18), 1708-1720. DOI: 10.1056/NEJMoa2002032.

Hamming, I., Timens, W., Bulthuis, M.L., Lely, A.T., Navis, G., & van Goor, H. (2004). Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. J. Pathol., 203 (2), 631-637. DOI: 10.1002/path.1570.

Zou, X., Chen, K., Zou, J., Han, P., Hao, J., & Han, Z. (2020). Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019nCoV infection. Front. Med., 14 (2), 185-192. DOI: 10.1007/s11684-020-0754-0.

Wang, Z., & Xu, X. (2020). scRNA-seq profiling of human testes reveals the presence of the ACE2 receptor, a target for SARS-CoV-2 infection in spermatogonia, Leydig and Sertoli cells. Cells, 9 (4), 920. DOI: 10.3390/cells 9040920.

Lardone, M.C., Piottante, A., Valdevenito, R., Ebensperger, M., & Castro, A. (2013). Histological and hormonal testicular function in oligo/azoospermic infertile men. Andrologia, 45 (6), 379-385. DOI: 10.1111/and.12026.

Gralinski, L.E., & Menachery, V.D. (2020). Return of the coronavirus: 2019-nCoV. Viruses, 12 (2), 135. DOI: 10.3390/v12020135.

Ding, Y., He, L., Zhang, Q., Huang, Z., & Che, X. (2004). Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathways. J. Pathol., 203 (2), 622-630. DOI: 10.1002/path.1560.

Sergerie, M., Mieusset, R., Croute, F., Daudin, M., & Bujan, L. (2007). High risk of temporary alteration of semen parameters after recent acute febrile illness. Fertil. Steril., 88 (4), 970. DOI: 10.1016/j.fertn stert.2006.12.045.

Evenson, D.P., Jost, L.K., Corzett, M., & Balhorn, R. (2000). Characteristics of human sperm chromatin structure following an episode of influenza and high fever: a case study. J. Andrology, 21 (5), 739-746. DOI: 10.1002/j.1939-4640.2000.tb021 42.x.

Holtmann, N., Edimiris, P., Andree, M., Doehmen, C., Baston-Buest, D., Adams, O., …, & Bielfeld, A.P. (2020). Assessment of SARS-CoV-2 in human semen-a cohort study. Fertil. Steril., 114 (2), 233-238. DOI: 10.1016/j.fertnstert.2020.05.028.

Song, C., Wang, Y., Li, W., Hu, B., Chen, G., Xia, P., …, & Liu, Y. (2020). Absence of 2019 Novel Coronavirus in Semen and Testes of COVID-19 Patients. Biol. Reprod., 103 (1), 4-6. DOI: 10.1093/biolre/ioaa050.

Ma, L., Xie, W., Li, D., Shi, L., Mao, Y., Xiong, Y., …, & Zhang, M. (2020). Effect of SARS-CoV-2 infection upon male gonadal function: a single center-based study. MedRxiv, 14. DOI: 10.1101/2020.03.21.20037267.

WHO. (1999). Laboratory manual for the examination of human semen and sperm-cervical mucus interaction (4th edn). Geneva: World Health Organization, Switzerland.

Fan, C., Li, K., Ding, Y., Lu, W., & Wang, J. (2020). ACE2 expression in kidney and testis may cause kidney and testis damage after 2019-nCoV infection, Front. Med. Retrieved from: https://doi.org/10.1101/2020.02.12.20022418.

Published

2022-05-03

How to Cite

Khmil, S. V., Mayorova, O. Y. ., Khmil, M. S., & Chorna, I. V. (2022). EFFECT OF COVID-19 ON MEN’S REPRODUCTIVE FUNCTION. Actual Problems of Pediatrics, Obstetrics and Gynecology, (2), 131–134. https://doi.org/10.11603/24116-4944.2021.2.12679

Issue

Section

OBSTETRICS AND GYNECOLOGY