EXPERIENCE OF USE OF PRP THERAPY IN WOMEN WITH INFERTILITY IN ADVANCED MATERNAL AGE
DOI:
https://doi.org/10.11603/24116-4944.2021.2.12605Keywords:
ovarian reserve, infertility, late reproductive ageAbstract
The aim of the study – improvement of the quality and quantity of the obtained oocytes in the treatment cycles of assisted reproductive technologies in women of advanced reproductive age by the injection of autologous platelet-rich plasma into ovaries.
Materials and Methods. The research involved 63 women of reproductive age (43 infertile patients prepared for ART and 20 healthy women). The general clinical methods of research included the analysis of medical history data, subjective complaints, objective examination of the reproductive system organs. The condition of the system of hypothalamus, hypophysis and ovaries was examined on the basis of the levels of gonadotropic and steroid hormones in blood serum measured with the use of immunoenzyme assay. The determination of the said figures was done with the use of the standard methods.
Results and Discussion. We regard the ovarian reserveas an important component of a womanʼs reproductive potential, which is indicative of the functional condition of the reproductive system and assessed on the basis of biochemical and ultrasonographic parameters. Women who are older than 35 experience the reduction of the follicular apparatus, with the reduction of the number and sizes of primordial and maturing follicles, fibrosis of the cortical layer associated with the fibrosis of vessel walls, cystic atresia of maturing follicles. The pathomorphological examination of the infertile patients allowed the study of the pathomorphogenesis of the ovarian dysfunction, where the leading factor is the dystrophic-atrophic reorganization of the follicular apparatus associated with the development of fibrosis of the organ, which is directly correlated with the patientsʼ age. The use of autologous platelet-rich plasma according to the suggested method has allowed a significant increase in the number of oocytes and improvement of the ART efficiency.
Conclusions. The obtained results show that the quality of the ovarian response to stimulation in women older than 35 years is determined by the condition of the patientsʼ ovarian reserve. The condition of the ovarian reserve fully reflects the prognosis of ART efficiency and achieving the desired pregnancy. The high efficiency and safety of the used method make it possible to recommend it for wide use in treating female infertility.
References
Henyk, N.I., & Yakymchuk, N.V. (2018). Modyfikatsiia prohramy prekontseptsiinoi pidhotovky na etapi planuvannia vahitnosti iz vrakhuvanniam psykhoemotsiinoho stanu zhinok [Modification of the pre-conceptional treatment program at the stage of pregnancy planning regarding the psychoemotional state of women]. Simeina medytsyna – Family Medicine, 5 (79), 128-131 [in Ukrainian].
Henyk, N.I., Yakymchuk, N.V., & Nesterak, R.V. (2012). Vyvchennia psykholohichnoi hotovnosti do materynstva v systemi psykhoprofilaktychnoi roboty po pidhotovtsi vahitnoi zhinky do polohiv [Study of psychological readiness for motherhood in the system of psychoprophylactic work to prepare a pregnant woman for childbirth]. Proceeding of Regional Scientific Practical Conference: «Psykhosomatychna medytsyna – shliakhy rozvytku» – "Psychosomatic Medicine – Ways of Development". Ivano-Frankivsk [in Ukrainian].
Dobryakov, I.V. (2014). Retrospektivnoye opredeleniye osobennostey psikhologicheskogo komponenta gestatsionnoy dominanty [Retrospective determination of the features of the psychological component of gestational dominance]. Voprosy psikhicheskogo zdorovya detey i podrostkov – Mental Health Issues in Children and Adolescents, 2, 71-75 [in Russian].
Znamenskaya, S.I., Kiselev, A.G., Shapovalova, Ye.A., & Maksimova, I.M. (2012). Osobennosti izmeneniy struktury psikhoemotsionalnoy sfery u zhenshchin po trimestram beremennosti [The peculiarities of changes in the structure of psychoemotional sphere in women during the gestation flavors of pregnanc]. Zhurnal akusherstva i zhenskikh bolezney – J. Obstet. Womenʼs Dis., LXI, 6, 30-35 [in Russian].
Kaminskiy, V.V., Genyk, N.I., Tkachuk, R.R., Herych, P.R., & Strimbitskiy, V.V. (2018). Vehetatyvni ta psykhosomatychni rozlady u zhinok pid chas vahitnosti [Autonomic and psychosomatic disorders in women during pregnancy]. Simeina medytsyna – Family Medicine, 3 (77), 129-137 [in Ukrainian].
Lytvynenko, N.V., Purdenko, T.Y., & Ostrovskaya, L.Y. (2015). Vehetatyvnyi ta psykhoemotsiinyi status zhinok u dynamitsi vahitnosti [Vegetative and psycho-emotional status of women in the course of pregnancy]. Simeina medytsyna – Family Medicine, 3 (59), 51-53 [in Ukrainian].
Lokhina, Ye.V., & Kachalina, T.S. (2013). Vliyaniye mediko-psikhologicheskoy podgotovki k rodam po programme «Schastlivoye materinstvo» na psikhoemotsionalnoye sostoyaniye zhenshchin v period beremennosti [The influence of medical and psychological preparation for childbirth under the program "Happy Motherhood" on the psycho-emotional state of women during pregnancy]. Meditsinskiy almanakh – Medical Almanac, 2 (26), 199-202 [in Russian].
Nikiforova, T.V., Agarkova, L.A., & Schastnyy, Ye.D. (2015). Ispolzovaniye standartizirovannykh shkal pri otsenke effektivnosti kognitivnoy psikhoterapii vo vremya beremennosti u depressivnykh patsiyentov s poterey ploda v anamneze [The use of standardized scales when evaluating the effectiveness of cognitive psychotherapy during pregnancy, depressed patients with loss of the fetus in history]. Uspekhi sovremennogo yestestvoznaniya – Advances Curr. Nat. Sci., 1 (6), 932-936 [in Russian].
Syusyuka, V.G. (2017). Otsinka parametriv vehetatyvnoho balansu ta aktyvnosti rehuliatornykh system u vahitnykh z urakhuvanniam yikh psykhoemotsiinoho stanu [Parameters estimation of vegetative balance and activity of regulatory systems of pregnant women in view of their psychoemotional state]. Perinatolohiia i pediatriia – Perinatology and Pediatrics, 2 (70), 64-68. DOI: 10.15574/pp.2017.70.64 [in Russian].
Syusyuka, V.G. (2016). Otsinka vplyvu prohramy medyko-psykholohichnoi korektsii psykhoemotsinoi dezadaptatsii u vahitnykh na perynatalni naslidky yikh rozrodzhennia [Estimation of influence of introduced program of medical and psychological correction of psychoemotional disadaptation of pregnant women on perinatal consequences of their delivery]. Perinatolohiia i pediatriia – Perinatology and Pediatrics, 3 (67), 43-48. DOI: 10.15574/PP.2016.67.43 [in Ukrainian].
Torchinov, A.M., Umakhanova, M.M., Doronin, G.L., Dzhonboboyeva, G.N., & Ron, M.G. (2013). Problema poteri beremennosti – diagnostika, vedeniye beremennosti, lecheniye i prognozy na sovremennom etape razvitiya akusherstva (obzor literatury) [Problem of pregnancy loss: diagnostics, pregnancy observation, treatment and forecasting at the modern stage of development of midwifery (literature review)]. Lechashchiy vrach – Attending Physician, 9, 85-91 [in Russian].
Filinov, A.G. (2016). Kardioritmogramma v otsenke vegetativnoy nervnoy sistemy v razlichnyye sroki normalno protekayushchey beremennosti [Cardiorhythmogramme in evaluation of vegetative nervous system within different terms of normal course of pregnancy]. Meditsinskiy almanakh – Medical Almanac, 5 (45), 55-58 [in Russian].
Filippova, G.G. (2015). Prenatalnyy stress: usileniye riska pri sovremennykh tekhnologiyakh vedeniya beremennosti i lecheniya besplodiya [Prenatal stress: increased risk with modern technologies of pregnancy management and infertility treatment]. Proceedings of the International Scientific Conference: «Psikhologycheskiye problemy sovremennoy semi» – "Psychological Problems of the Modern Families”. Moscow – Zvenigorod (pp. 418-426) [in Russian].
Allaire, A.D. (2014). Placenta apoptosis in preeclampsia. Obstet. Gynecol., 96 (2), 271-276. DOI: 10.1016/s0029-7844(00)00895-4.
Ananth, C.V. (2014). Ischemic placental disease: a unifying concept forpreeclampsia, intrauterine growth restriction, and placental abruption. Semin. Perinatol., 38 (3), 131-132. DOI: 10.1053/j.semperi.2014.03.001.
Anderson, G., & Maes, M. (2013). Postpartum depression: psychoneuroimmunological underpinnings and treatment. Neuropsychiatr. Dis. Treat., 9, 277. DOI: 10.2147/NDT.S25320.
Bartsch, E., Medcalf, K.E., Park, A.L., & Ray, J.G. (2016). Clinical risk factors for preeclampsia determined in earlypregnancy: systematic review and meta-analysis of large cohort studies. BMJ, 353, i1753. DOI: 10.1136/bmj.i1753.
Blankley, G., Galbally, M., Snellen, M., Power, J., & Lewis, A.J. (2015). Borderlinepersonality disorder in the perinatal period: early infant and maternal outcomes. Australas Psychiatry., 23 (6), 688-692. DOI: 10.1177/1039856215590254.
Bogaerts, A.F., Devlieger, R., Nuyts, E., Witters, I., Gyselaers, W., Guelinckx, I., & Van den Bergh, B.R.H. (2013). Anxiety and depressed mood in obese pregnant women: a prospective controlledcohort study. Obes. Facts., 6 (2), 152-164. DOI: 10.1159/000346315.
Cuijpers, P., Vogelzangs, N., Twisk, J., Kleiboer, A., Li, J., &Penninx,B.W. (2013). Differential mortality rates in major and subthreshold depression: a meta-analysis ofstudies that measured both. Br. J. Psychiatry, 202 (1), 22-27. DOI: 10.1192/bjp.bp.112.112169.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Actual Problems of Pediatrics, Obstetrics and Gynecology
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish in this journal agree to the following terms:
1. The authors reserve the right to authorship of the work and pass the journal right of first publication of this work is licensed under a Creative Commons Attribution License, which allows others to freely distribute the work published with reference to the authors of the original work and the first publication of this magazine.
2. Authors are entitled to enter into a separate agreement on additional non-exclusive distribution of work in the form in which it was published in the magazine (eg work place in the electronic repository institution or publish monographs in part), provided that the reference to the first publication of this magazine.
3. Policy magazine allows and encourages authors placement on the Internet (eg, in storage facilities or on personal websites) manuscript of how to submit the manuscript to the editor and during his editorial processing, since it contributes to productive scientific discussion and positive impact on the efficiency and dynamics of citing published work (see. The Effect of Open Access).
