FEATURES OF THE COURSE OF MULTIPLE PREGNANCIES, CHILDBIRTH AND THE STATE OF NEWBORNS IN WOMEN WITH THE ART AND THE USE OF OBSTETRIC UNLOADING PESSARY
DOI:
https://doi.org/10.11603/24116-4944.2021.2.12604Keywords:
multiple pregnancy, unloading obstetric pessary, assisted reproductive technologies, premature childbirth, miscarriageAbstract
The purpose of the study – to explore the anamnestic features, the frequency of obstetric and perinatal complications in women with multiple pregnancy (MP) after the use of assisted reproductive technologies (ART), and evaluate the results after applying the obstetric unloading pessary in order to prevent miscarriage of pregnancy and premature birth.
Materials and Methods. An analysis of 35 women with MP with the use of ART was carried out. Studied anamnestic data, the course of pregnancy and the results of ultrasound of the state of fetuses and cervix. Patients were installed obstetric unloading pessary on the period of pregnancy 16-20 weeks with a prophylactic goal.
Results and Discussion. Through the study of anamnestic data in women with MP after ART, a number of somatic and gynecological pathologies have been established, which could affect the course of pregnancy and the intrauterine state of babies. 13 (37,1 %) of pregnant women were revealed diseases of the urine-separation system, 7 (20 %) – of eyes (myopia), 5 (14,2 %) – of cardiovascular system, 3 (8,5 %) – gastrointestinal disorders, 2 (2,7 %) – diseases of respiratory organs with signs of pulmonary failure. Pathologies that could affect the course of pregnancy: 28 (80 %) patients had placental dysfunction, 18 (51,4 %) – anemia, 12 (34,2 %) – polyhydramnios, 8 (22,8 %) – preeclampsia. According to the cervicometry, ICI (shortening the cervix to <25 mm) is diagnosed of 2 (5,7 %) women. 15 (42,8 %) of patients for the period of gestation were diagnosed by the threat of interrupting pregnancy, 20 (57,1 %) – the threat of premature births. In order to prevent abortion in these patients, an obstetric unloading pessary was installed at the optimal time of 16-20 weeks of pregnancy. All 35 (100 %) surveyed women gave birth during full-term pregnancy (37-39 weeks): in 2 (2,7 %) deliveries were vaginal, in 33 (94,2 %) – planned cesarean section according to indications. In 3 (8,5 %) patients babies with low body weight were born: in one – one newborn due to a violation of the placental complex of the fetus, in the second – one fetus of twins with discordant development, in the third – both newborns with intrauterine growth retardation due to mother’s COVID -19 at 28–29 weeks gestation.
Conclusions. The course of MP after the use of ART constitutes a high risk of developing a number of maternal and perinatal complications. The use of an obstetric unloading pessary allows to prolong pregnancy until the optimal time for delivery and fetal maturity.
References
Bespalova, O.N., & Sargsyan, G.S. (2017). Vybor metoda korrektsii istmiko-tservikalnoy nedostatochnosti [Selection of the method for correction of cervical incompetence]. Zhurnal akusherstva i zhenskih bolezney – J. Obstet. Women's Dis., 66 (3), 157-168. DOI: 10.17816/JOWD663157-168 [in Russian].
Bespalova, O.N., & Sargsyan, G.S. (2017). Effektivnost primeneniya akusherskogo pessariya pri ugrozhayushchih prezhdevremennyh rodah i korotkoy sheyke matki [The effectiveness of the obstetric pessary for threatening preterm birth and short cervix]. Meditsinskiy Sovet – Medical Council, 13, 118-126. DOI: 10.21518/2079-701x-2017-13-118-126 [in Russian].
Vasylyshyna, V.R. (2014). Porivnialni aspekty bahatoplidnoi vahitnosti bez i pislia dopomizhnykh reproduktyvnykh tekhnolohii [Comparative aspects multipara pregnancy without and after auxiliary reproductive technologies]. Candidateʼs thesis. Кyiv. Retrieved from: https://nmapo.edu.ua/zagruzka/DrAr/ArVasilishina.pdf [in Ukrainian].
Ventskivsky, B.M., Poladych, I.V. (2016). Patohenetychni mekhanizmy nevynoshuvannia u zhinok z bahatoplidnoiu vahitnistiu, zumovlenoiu zastosuvanniam dopomizhnykh reproduktyvnykh tekhnolohii [Pathogenetic mechanisms of miscarriage in women with a multiple pregnancy, due to the use of ART]. Zdorovye zhenshchiny – Health of a Woman, 6, 173-176 [in Ukrainian].
Dobrokhotova, Yu.E., Borovkova, E.I., Zalesskaya, S.A., Nagaitseva, E.A., & Raba, D.P. (2018). Diagnostika i taktika vedeniya patsientok s istmiko-tservikalnoy nedostatochnostyu [Diagnosis and management patients with cervical insufficiency]. Ginekologiya – Gynecology, 20 (2), 41-45. DOI: 10.26442/2079-5696_2018.2.41-4 [in Russian].
Kovalenko, T.S., Chechneva, M.A., Kapustina, M.V., Zemskova, N.Iu., Yakhontova, O.A, & Akhvlediani, K.N. (2018). Istmiko-tservikalnaya nedostatochnost pri mnogoplodnoy beremennosti [Isthmic-cervical insufficiency in multiple pregnancies]. Rossiyskiy vestnik akushera-ginekologa – Rus. Bull. Obstet. Gynecol., 18 (1), 44-50. DOI: 10.17116/rosakush201818144-50 [in Russian].
Astrakhantseva, M.M., Breusenko, L.E., Lebedev, E.V., Plekhanova, E.R., Saveleva, G.M., & Shalina, R.I. (2016). Istmiko-tservikalnaya nedostatochnost. Diagnostika i korrektsiya [Isthmicocervical insufficiency: Diagnosis and correction]. Rossiyskiy vestnik akushera-ginekologa – Rus. Bull. Obstet. Gynecol., 16 (2), 83-88. DOI: 10.17116/rosakush201616283-88 [in Russian].
Barinov, S.V., Artyimuk, N.V., Novikova, O.N., Shamina, I.V., Tirskaya, Yu.I., & Beglov, D.E. (2019). Opyt vedeniya beremennyh gruppy vysokogo riska po prezhdevremennym rodam s primeneniem akusherskogo kupoloobraznogo pessariya i serklyaya [Experience in managing pregnant women at high risk for preterm birth, by using a dome-shaped obstetric pessary and cerclage]. Akusherstvo i ginekologiya – Obstet. Gynecol., 1, 140-148. DOI: 10.18565/aig.2019.1.140-148 [in Russian].
Noskova, O.V., Churilov, A.V., Sviridova, V.V., & Litvinova, E.V. (2019). Osobennosti techeniya beremennosti, rodov i perinatalnyie ishodyi u beremennyih s istmiko-tservikalnoy nedostatochnostyu [Features of the course of pregnancy, childbirth and perinatal outcomes in pregnant women with isthmic-cervical insufficiency]. Vestnik gigienyi i epidemiologii – Bull. Hygiene Epidemiol., 23 (3), 247-250 [in Ukrainian].
Barinov, S.V., Belinina, A.A., Koliado, O.V., Molchanova, I.V., Shkret, A.A., & Stepanov, S.S. (2020). Prediktoryi nevyinashivaniya pri mnogoplodnoy beremennosti [The predictors of preterm labour in patients with multiple pregnancy]. Meditsinskiy Sovet – Medical Council, 3, 144-150. DOI: 10.21518/2079-701X-2020-3-144-150 [in Russian].
Bondarenko, K.R., Kuznetsov, P.A., Dzhokhadze, L.S., Lyan, V.V., Kriger, A.V., & Eletnova, E.S. (2020). Tsentilnyie nomogrammyi dlya otsenki massy i dliny novorozhdennyh pri mnogoplodnoy beremennosti [Centile nomograms for body weight and length of multiple-birth infants]. RMJ. Mat i ditya – Russian Journal of Woman and Child Health, 3 (1), 20-25. DOI: 10.32364/2618-8430-2020-3-1-20-25 [in Russian].
Yakovleva, O.V., Glukhova, T.N., & Rogozhina, I.E. (2020). Osnovnye printsipy vedeniya beremennosti posle vspomogatelnyh reproduktivnyh tehnologiy [Basic principles for the management of pregnancy after assisted reproductive]. Meditsinskiy vestnik Severnogo Kavkaza – Medical News of North Caucasus, 15 (1), 140-145. DOI: https://doi.org/10.14300/mnnc.2020.15035 [in Russian].
Barinov, S.V., Artymuk, N.V., Novikova, O.N., Shamina, I.V., Tirskaya, Y.I., Belinina, & Di Renzo, G.C. (2021). Analysis of risk factors and predictors of pregnancy loss and strategies for the management of cervical insufficiency in pregnant women at a high risk of preterm birth. J. Matern. Fetal Neonatal Med., 34 (13), 2071-2079. DOI: 10.1080/14767058.2019.1656195.
Hamilton, B.E., Martin, J.A., Osterman, M.J., Curtin, S.C., & Matthews, T.J. (2015). Births: final data for 2014. Nat. Vital Stat. Rep, 64 (12), 1-64.
Brown, R., Gagnon, R., & Delisle, M.F. (2019). No. 373-Cervical insufficiency and cervical cerclage. J. Obstet. Gynaecol. Can., 41 (2), 233-247. DOI: 10.1016/j.jogc.2018.08.009.
Guideline Summary: VA/DoD clinical practice guideline for the management of pregnancy.Prepared by: The Management of Pregnancy Work Group With support from: The Office of Quality, Safety and Value, VA, Washington, DC & Office of Evidence Based Practice, U.S. Army Medical Command Version 3.0 – 2018 Based on evidence reviewed through May 2017. 2018. Retrieved from: https://www.healthquality.va.gov/guidelines/WH/up/VADoDPregnancyCPG4102018.pdf.
Marasinghe, J.P. (2016). Cеrvіcаl pеssаrу аnd vаgіnаl prоgеstеrоnе іn twіn prеgnаncіеs wіth а shоrt cеrvіx. Obstet. Gynecol., 128 (2), 408. DOI: 10.1097/AOG.0000000000001546.
Vink, J., & Feltovich, H. (2016). Cervical etiology of spontaneous preterm birth. Semin. Fetal Neonatal Med., 21 (2), 106-112. DOI: https://doi.org/10.1016/j.siny.2015.12.009.
Boiko, V.I., Nikitina, I.N., Babar, T.V., & Boiko, А.V. (2018). The problem of miscarriage in multiple pregnancу. Wiad. Lek., 71 (7), 1195-1199.
Vygivska, L.M., Nykoniuk, T.R., & Oleshko, V.F. (2017). The optimization ways of pregnancy and labor management tactics in women after application of assisted reproductive technologies. Zdorovye Zhenshchiny – Health of a Woman, 9, 111-113. Retrieved from: http://nbuv.gov.ua/UJRN/Zdzh_2017_9_22 [in Ukrainian].
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Actual Problems of Pediatrics, Obstetrics and Gynecology
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish in this journal agree to the following terms:
1. The authors reserve the right to authorship of the work and pass the journal right of first publication of this work is licensed under a Creative Commons Attribution License, which allows others to freely distribute the work published with reference to the authors of the original work and the first publication of this magazine.
2. Authors are entitled to enter into a separate agreement on additional non-exclusive distribution of work in the form in which it was published in the magazine (eg work place in the electronic repository institution or publish monographs in part), provided that the reference to the first publication of this magazine.
3. Policy magazine allows and encourages authors placement on the Internet (eg, in storage facilities or on personal websites) manuscript of how to submit the manuscript to the editor and during his editorial processing, since it contributes to productive scientific discussion and positive impact on the efficiency and dynamics of citing published work (see. The Effect of Open Access).