OPTIMIZATION OF DIAGNOSIS OF DEGREE OF PREECLAMPSIA DIFFICULTY ON THE BACKGROUND OF METABOLIC SYNDROME WITH ASSESSMENT OF PSYCHOSOMATIC CONDITION OF WOMEN
DOI:
https://doi.org/10.11603/24116-4944.2021.1.12371Keywords:
preeclampsia, uric acid, serum iron, metabolic syndromeAbstract
The aim of the study – to optimize markers for determining the severity of preeclampsia in women on the background of metabolic syndrome with an assessment of their psychosomatic state.
Materials and Methods. We examined 60 pregnant women in the third trimester of pregnancy (28–38 weeks of pregnancy), depending on the presence and absence of preeclampsia, severity and metabolic syndrome. In mild preeclampsia on the background of metabolic syndrome, the level of uric acid exceeded the control by about 1.3 times, and in moderate preeclampsia on the background of metabolic syndrome, this figure exceeded the control group by one and a half times.
Results and Discussion. Thus, with increasing severity of preeclampsia on the background of metabolic syndrome there is an increase in the level of uric acid in the blood, which may indicate a prognostic criterion for preeclampsia. In determining the serum iron, we also found quite significant changes. In mild preeclampsia, serum iron levels increased significantly compared with the control group, and increased even more in moderate preeclampsia. Analyzing the data obtained, we can talk about a violation of serum iron metabolism in preeclampsia. Assessing the psycho-emotional state of women, it was found that most of the surveyed pregnant women tend to perceive situations as threatening, react to them with anxiety, nervousness and anxiety.
Conclusion. Evaluating the study data, the importance of determining the level of uric acid and serum iron as markers for assessing the degree of preeclampsia on the background of metabolic syndrome.
References
Aplin, J.D., Myers, J.E., Timms, K., & Westwood, M. (2020). Tracking placental development in health and disease. Nat. Rev. Endocrinol., 16 (9), 479-494. DOI: 10.1038/s41574-020-0372-6.
Farhat, S., Zafar, M.U., Sheikh, M.A., Qasim, C.M., Urooj, F., & Fatima, S.S. (2020). Association of resolvin level in pregnant women with preeclampsia and metabolic syndrome. Taiwan J. Obstet. Gynecol, 59 (1), 105-108. DOI: 10.1016/j.tjog.2019.11.016.
Brown, D. (2020). Preeclampsia, hypertension, and a possible treatment for preeclampsia. Med. Hypotheses., 140, 109669. DOI: 10.1016/j.mehy.2020.109669.
Banadakoppa, M., Balakrishnan, M., & Yallampalli, C. (2020). Common variants of fetal and maternal complement genes in preeclampsia: pregnancy specific complotype. Sci. Rep., 10 (1), 4811. DOI: 10.1038/s41598-020-60539-9.
Gutierrez-Aguirre, C.H., García-Lozano, J.A., Treviño-Montemayor, O.R., Iglesias-Benavides, J.L., Cantú-Rodríguez, O.G., González-Llano, & Gómez-Almaguer, D. (2017). Comparative analysis of iron status and other hematological parameters in preeclampsia. Hematology, 22 (1), 36-40. DOI: 10.1080/10245332.2016.1220120.
Choi, S.Y., Kim, K.H., Lee, M., Yeo, M.K., Kim, J., & Suh, K.S. (2020). Complement component C4d deposition in the placenta of preeclampsia patients and renal glomeruli in 1 postpartum renal biopsy. Appl. Immunohistochem. Mol. Morphol., 28 (2), 139-145. DOI: 10.1097/PAI.0000000000000755.
Yuliani, D., Hadisaputro, S., & Nugraheni, S. (2019). Distribution of preeclampsia risk factors in pregnant woman with mild preeclampsia in banyumas district. J. Kebid, 9, 135. DOI: 10.31983/jkb.v9i2.5162.
Ababio, G.K., Adu-Bonsaffoh, K., Abindau, E., Narh, G., Tetteh, D., Botchway, F., & Quaye, I.K. (2019). Effects of factor v Leiden polymorphism on the pathogenesis and outcomes of preeclampsia. BMC Med. Genet., 20 (1), 189. DOI: 10.1186/s12881-019-0924-6.
Ma'ayeh, M., Krishnan, V., Gee, S.E., Russo, J., Shellhaas, C., & Rood, K.M. (2020). Fetal renal artery impedance in pregnancies affected by preeclampsia. J. Perinat. Med. DOI: 10.1515/jpm-2020-0024.
Pasyar, S., Wilson, L.M., Pudwell, J., Peng, Y.P., & Smith, G.N. (2020). Investigating the diagnostic capacity of uric acid in the occurrence of preeclampsia. Pregnancy Hypertens, 19, 106-111. DOI: 10.1016/j.preghy.2019.12.010.
Ma'ayeh, M., Rood, K.M., Kniss, D., & Costantine, M.M. (2020). Novel interventions for the prevention of preeclampsia. Curr. Hypertens. Rep., 22 (2), 17. DOI: 10.1007/s11906-020-1026-8.
Murthi, P., Pinar, A.A., Dimitriadis, E., & Samuel, C.S. (2020). Inflammasomes-A molecular link for altered immunoregulation and inflammation mediated vascular dysfunction in preeclampsia. Int. J. Mol. Sci., 21 (4), 1406. DOI: 10.3390/ijms21041406.
Ryu, A., Cho, N.J., Kim, Y.S., & Lee, E.Y. (2019). Predictive value of serum uric acid levels for adverse perinatal outcomes in preeclampsia. Medicine, 98 (18), e15462. DOI: 10.1097/MD.0000000000015462.
Riwa, A., Ghulmiyyah, L., Hobeika, E., Usta, I., Mirza, F., & Nassar, A. (2021). Preeclampsia: a review of early predictors. Mat. Fet. Med. DOI: 10.1097/FM9.0000000000000088. Pub Ah of Pr.
Nirupama, R., Sheshadri, D., Janhavi, P., Peddha, M., & Ravindra, P. (2020). Preeclampsia: Pathophysiology and management. J. Gynecol. Obstet. Hum. Reprod, 50 (2). DOI: 10.1016/j.jogoh.2020.101975.
Schuster, J., Cheng, S.B., Padbury, J., & Sharma, S. (2021). Placental extracellular vesicles and pre-eclampsia. Am. J. Reprod. Immunol., 85 (2), e13297. DOI: https://doi.org/10.1111/aji.13297.
Sibai, B.M., & Stella, C.L. (2009). Diagnosis and management of atypical preeclampsia-eclampsia. Am. J. Obstet. Gynecol., 200 (5), 481. e1-7. DOI: 10.1016/j.ajog.2008.07.048.
Masoura, S., Makedou, K., Theodoridis, T., Kourtis, A., Zepiridis, L., & Athanasiadis, A. (2015). The involvement of uric acid in the pathogenesis of preeclampsia. Curr. Hypertens. Rev., 11 (2), 110-115. DOI: 10.2174/1573402111666150529130703.
Michalczyk, M., Celewicz, A., Celewicz, M., Woźniakowska-Gondek, P., & Rzepka, R. (2020). The role of inflammation in the pathogenesis of preeclampsia. Mediators Inflamm., 2020, 3864941. DOI: 10.1155/2020/3864941.
Khaliq, O.P., Konoshita, T., Moodley, J., & Naicker, T. (2018). The role of uric acid in preeclampsia: is uric acid a causative factor or a sign of preeclampsia? Curr. Hypertens. Rep., 20 (9), 80. DOI: 10.1007/s11906-018-0878-7.
Dhariwal, N.K., & Lynde, G.C. (2017). Update in the management of patients with preeclampsia. Anesthesiol. Clin., 35 (1), 95-106. DOI: 10.1016/j.anclin.2016.09.009.
Zhao, X., Frempong, S.T., & Duan, T. (2019). Uric acid levels in gestational hypertensive women predict preeclampsia and outcome of small-for-gestational-age infants. J. Matern. Fetal. Neonatal. Med., 1-7. DOI: 10.1080/14767058.2019.1671339.
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