SUCCESSFUL TREATMENT OF SEVERE OVARIAN HYPERSTIMULATION SYNDROME IN EARLY PREGNANCY (CASE REPORT)

Authors

DOI:

https://doi.org/10.11603/24116-4944.2021.1.12361

Keywords:

ovarian hyperstimulation syndrome, in vitro fertilization, pregnancy

Abstract

The aim of the study – description of a clinical case using the various methods of diagnosis and treatment of ovarian hyperstimulation syndrome in the early pregnancy.

Materials and Methods. A 34-year-old patient Z. presented with severe ovarian hyperstimulation syndrome that arose in the early pregnancy, which was a result of in vitro fertilization. For the purpose of investigation and monitoring of the patient condition complete blood count, basic metabolic panel, urine test and ultrasonography of the abdomen and the chest were performed. Management was based on the current Ukrainian medical guidelines.

Results and Discussion. After a thorough investigation of this clinical case we made a conclusion that ovarian hyperstimulation syndrome had started to develop immediately after oocytes retrieval and the clinical presentation of the ovarian hyperstimulation syndrome corresponded to the grade 3 of the severity.

Conclusions. Application of a comprehensive approach in the diagnosis and treatment of ovarian hyperstimulation syndrome allows tracing the dynamics of the pathological process under the influence of early term pregnancy and treatment measures. Needless to say, ovarian hyperstimulation syndrome is considered as an important risk factor that contributes to the complications of pregnancy after IVF and reproductive loss during the first trimester. Therefore, every patient should have an individual approach when choosing in vitro fertilization protocols, taking into account the personal risk to develop ovarian hyperstimulation syndrome.

Author Biography

D. V. Letsyn, Zaporizhia State Medical University

Postgraduate student, Department of Obstetric, Gynecology and Reproductive Medicine Faculty of Graduate Studies, Zaporizhzhia State Medical University

References

Sagamonova, K.Yu., Levchenko, M.V., Klepikova, A.A., Kazantseva, T.A., Arabadzhan, S.M., & Pivovarchik, S.N. (2016). Sluchay uspeshnogo lecheniya giperstimulyatsii yaichnikov tyazheloy stepeni [Successful treatment of severe ovarian hyperstimulation degree (case report)]. Problemy reproduktsii – Reproduction Problems, 22 (3), 63-66. DOI: 10.17116/repro201622363-66 [in Russian].

Egorova, E.A., & Terenteva, A. P. (2015). Sindrom giperstimulyatsii yaichnikov (obzor literatury i klinicheskoye nablyudeniye) [Ovarian hyperstimulation syndrome (the review of the literature and case report)]. Radiologiya – Praktika – Radiology – Practice, 3 (51), 29-36 [in Russian].

Alekhina, A.G., Petrov, Yu.A., & Blesmanovich, A.E (2018). Sindrom giperstimulyatsii yaichnikov v realiyakh nashego vremeni [Ovarian hyperstimulation syndrome in the realities of our time]. Zdorovye i obrazovaniye – Health and Education, 20 (4), 22-26 DOI: http://dx.doi.org/10.26787/nydha-2226-7425-2018-20-4 [in Russian].

Ermolenko, K.S., Radzinsky, V.E., Khamoshina, M.B., & Kostin, I.N. (2017) Kontroliruyemaya giperstimulyatsiya v programmakh ekstrakorporalnogo oplodotvoreniya u patsiyentok s anovulyatornym besplodiyem: chem menshe, tem luchshe? [Controlled ovarian hyperstimulation in patients with anovulatory infertility participating in in vitro fertilization programs: the less the better?]. Doctor. Ru., 9 (138), 69-73 [in Russian].

Bitsadze, V.O., Akinshina, S.V., Andreeva, M.D., & Makatsariya, A.D. (2013). Tromboembolicheskiye oslozhneniya, svyazannyye s ispolzovaniyem vspomogatelnykh reproduktivnykh tekhnologiy. Sindrom giperstimulyatsii yaichnikov [Thromboembolic complications related to the use of assistive reproductive treatment. Ovarian hyperstimulation syndrome]. Prakticheskaya meditsina – Practical Medicine, 7 (76), 20-31 [in Russian].

Айзятулова, Е. М. (2016). Suchasnyi pidkhid shchodo provedennia kontrolovanoi stymuliatsii yaiechnykiv u tsyklakh dopomizhnykh reproduktyvnykh tekhnolohii u zhinok iz vysokym ryzykom syndromu hiperstymuliatsii yaiechnykiv [Modern approach concerning controlled ovarian stimulation in circles of additional reproductive technologies in women with high risk of ovarian hyper stimulation syndrome]. Aktualni pytannia pediatrii, akusherstva ta hinekolohii – Actual Problems of Pediatrics, Obstetrics and Gynecology, 1, 34-33 DOI: https://doi.org/10.11603/24116-4944.2016.1.5980 [in Ukrainian].

Avramenko, N.V., Kabachenko, O.V., Barkovskyi, D.Ye., & Kopiika, V.V. (2018). Zahalnoklinichni, biokhimichni pokaznyky ta riven hormoniv peryferychnoi krovi zhinok v umovakh syndromu hiperstymuliatsii yaiechnykiv [General clinical, biochemical parameters and peripheral blood hormone level in women at ovarian hyperstimulation syndrome]. Mizhnarodnyi medychnyi zhurnal – International Medical Journal, 2, 41-45 [in Ukrainian].

Dzyuba, D.O., Dynya, A.B., Haan, I.A., & Halushko, O.A. (2017). Porushennia vodno-elektrolitnoho balansu ta yikh korektsiia [Violations of water-electrolyte balance and their correction]. Hostri ta nevidkladni stany u praktytsi likaria – Acute and Urgent Conditions in the Doctors Practice, 3 (66), 17-21 [in Ukrainian].

Abramyan, G.R. (2017). Profilaktika trombozov v programmakh vspomogatelnykh reproduktivnykh tekhnologiy [Prophylaxis of thrombosis in programs of assisted reproductive technologies]. Prakticheskaya meditsina – Practical Medicine, 7 (108), 143-146 [in Russian].

Martazanova, B.A., Mishiyeva, N.G., Vedikhina, I.A., Aksenenko, A.A., Ipen, S.M., Ibragimova, M.Kh., ..., & Abubakirov, A.N. (2015). Gormonalnyy profil posle zameny triggera ovulyatsii u zhenshchin s vysokim riskom razvitiya sindroma giperstimulyatsii yaichnikov [Hormonal profile after ovulation trigger replacement in women at high risk of ovarian hyperstimulation syndrome]. Akusherstvo i ginekologiya – Obstetrics and Gynecology, 6, 84-90 [in Russian].

Shlapak, I.P., Holubovska, O.A., & Halushko, O.A. (2015). Dehidratatsiinyi syndrom [Dehydration syndrome]. Hostri ta nevidkladni stany u praktytsi likaria – Acute and Urgent Conditions in the Doctors Practice, 6 (56), 15-19 [in Ukrainian].

Ivakhnenko Ye.V. (2015). Dinamika elektrolitov plazmy krovi i mochi na etapakh nablyudeniy pri razlichnykh tipakh infuzionnoy terapii u patsiyentov s infektsionno-toksicheskim shokom [Dynamics of blood plasma and urine electrolytes at the stages of observation in various types of infusion therapy in patients with toxic shock syndrome]. Meditsina neotlozhnykh sostoyaniy – Emergency Medicine, 4, 28-31 [in Russian].

Veropotvelyan, P.N., Tsekhmistrenko, I.S., Veropotvelyan, N.P., & Goruk, P.S. (2016). Prakticheskiy podkhod k vedeniyu patsiyentok s sindromom giperstimulyatsii yaichnikov [A practical approach to the management of patients with ovarian hyperstimulation syndrome]. Meditsinskiye aspekty zdorovya zhenshchiny – Medical Aspects of a Woman's Health, 8 (105), 42-51 [in Russian].

Kulikov, A.V., Shifman, Ye.M., & Portnov, I.G. (2015). Intensivnaya terapiya sindroma giperstimulyatsii yaichnikov (klinicheskiye rekomendatsii) [Intensive therapy of ovarian hyperstimulation syndrome (clinical guidelines)]. Anesteziologiya i reanimatologiya – Anesthesiology and Reanimatology, 1, 73-76 [in Russian].

Shcherbakova, L.N., Ivanova, N.V., Bugerenko, A.Ye., & Panina, O.B. (2015). Preduprezhdeniye razvitiya sindroma giperstimulyatsii yaichnikov v programme ekstrakorporalnogo oplodotvoreniya [The prevention of development of syndrome of hyper-stimulation of ovary in program of extra-corporeal fertilization]. Rossiyskiy meditsinskiy zhurnal – Russian Medical Journal, 21 (1), 28-31 [in Russian].

Vorotnikova, S.Yu. (2012). Primeneniye kabergolina dlya profilaktiki i lecheniya sindroma giperstimulyatsii yaichnikov [The use of cabergoline for the prevention and treatment of ovarian hyperstimulation syndrome]. Ozhireniye i metabolism – Obesity and Metabolism, 9 (4), 48-50 [in Russian].

Shvets, M.V. (2017). Mechanisms of hormonal systems regulating water-salt metabolism. Clin. Exp. Pathol., 3,103.

Abuzeid, M., Warda, H., Joseph, S., Corrado, M.G., Abuzeid, Y., Ashraf, M., & Rizk, B. (2014). Outpatient management of severe ovarian hyperstimulation syndrome (OHSS) with placement of pigtail catheter. FVV in ObGyn, 6 (1), 31-37.

Humaidan, P., Nelson, S.M., Devroey, P., Coddington, C.C., Schwartz, L.B., Gordon, K., ..., & Stegmann, B.J. (2016). Ovarian hyperstimulation syndrome: review and new classification criteria for reporting in clinical trials. Hum. Reprod., 31 (9), 1997-2004. DOI: 10.1093/humrep/dew149 [in Russian].

Timmons, D., Montrief, T., Koyfman, A., & Long, B. (2019). Ovarian hyperstimulation syndrome: a review for emergency clinicians. Am. J. Emerg. Med., 37 (8), 1577-1584. DOI: 10.1016/j.ajem.2019.05.018.

Published

2021-09-09

How to Cite

Letsyn, D. V. (2021). SUCCESSFUL TREATMENT OF SEVERE OVARIAN HYPERSTIMULATION SYNDROME IN EARLY PREGNANCY (CASE REPORT). Actual Problems of Pediatrics, Obstetrics and Gynecology, (1), 87–92. https://doi.org/10.11603/24116-4944.2021.1.12361

Issue

Section

OBSTETRICS AND GYNECOLOGY