VITAMIN D SUPPLY AND METABOLIC SYNDROME IN OBSESSED ADOLESCENT CHILDREN
DOI:
https://doi.org/10.11603/24116-4944.2021.1.12348Keywords:
vitamin D, deficiency, obesity, metabolic syndromeAbstract
The aim of the study – to analyze the data of scientific publications that highlight the state of vitamin D supply and its relationship with the development of metabolic syndrome in adolescents.
Materials and Methods. The analysis of Web of Sciense, SpringerOpen, Structure (NCBI), HINARI, PudMed, Scopus data, which describe the state of vitamin D supply of children depending on body mass index and its relationship with anthropometry, carbohydrate and lipid metabolism.
Results and Discussion. Obesity and vitamin D deficiency contribute to the development of metabolic syndrome criteria in adolescents. Important factors in the development of vitamin D deficiency and metabolic syndrome are low income per family member, insufficient consumption of milk, foods fortified with vitamin D, low physical activity, insufficient exposure to the outdoors, prolonged spending time at the computer, gadgets. Vitamin D supplementation in obese adolescents is characterized by direct correlations with serum levels of high-density lipoprotein and inverse correlations with waist circumference, triglycerides, glycemia, and hypertension.
Conclusions. Vitamin D deficiency is associated with risk factors for metabolic syndrome in obese children. The prevalence of vitamin D deficiency among adolescents depends on many factors that are thought to play an important role in the increased risk of developing metabolic syndrome. Establishing mechanisms for the relationship between vitamin D deficiency and metabolic risk factors in obese children will allow the development of new approaches to reduce the risk of obesity, metabolic syndrome and related cardiovascular disease.
References
Zelinska, N.B. (2018). Ozhyrinnia v ditei: vyznachennia, likuvannia, profilaktyka. Klinichni praktychni nastanovy Endokrynolohichnoho Tovarystva Chastyna 2 [Obesity in children: identification, treatment, prevention. Clinical practice guidelines of Endocrine Society. Part 1]. Ukraiinskyi zhurnal dytiachoi endokrynolohii – Ukrainian Journal of Pediatric Endocrinology, 1, 65-76 [in Ukrainian].
Zelinska, N.B. (2013). Ozhyrinnia ta metabolichnyi syndrom u ditei [Obesity and metabolic syndrome in children]. Klinichna endokrynolohiia ta endokrynna khirurhiia – Clinical Endocrinology and Endocrine Surgery, 4, 62-72 [in Ukrainian].
Alleyne, G., Nishtar, S., Chan Hon Yee, C., Radcliffe, P., Clark, H., et al. (2015). Draft final report of the commission on ending childhood obesity. Geneva, Switzerland: World Health Organization.
Skinner, A.C., Ravanbakht, S.N., Skelton, J.A., Perrin, E.M., & Armstrong, S.C. (2018). Prevalence of obesity and severe obesity in us children, 1999-2016. Pediatrics, 141 (3), e20173459. DOI: 10.1542/peds.2017-3459.
Zabolotna, I.E., & Yashchenko, L.V. (2019). Ozhyrinnia ta nadmirna masa tila v ditei, kryterii diahnostyky ta statystyka poshyrenosti [Obesity and overweight among children, diagnostic criteria and statistics of prevalence]. Klinichna ta profilaktychna medytsyna – Clinical and Preventive Medicine, 8 (2), 36-46 [in Ukrainian].
Dev, D.A., McBride, B.A., Fiese, B.H., Jones, B.L., & Cho, H. (2013). Behalf of the strong kids research team. Risk factors for overweight/obesity in preschool children: an ecological approach. Child Obes., 9 (5), 399‐408. DOI: 10.1089/chi.2012.0150.
Chung, S.T., Onuzuruike, A.U., & Magge, S.N. (2018). Cardiometabolic risk in obese children. Ann. N. Y. Acad. Sci., 1411 (1), 166-183. DOI: 10.1111/nyas.13602.
Kostovski, M., Simeonovski, V., Mironska, K., Tasic, V., & Gucev, Z. (2018). Metabolic profiles in obese children and adolescents with insulin resistance. Open Access Maced. J. Med. Sci., 6 (3), 511-518. DOI: 10.3889/oamjms.2018.097.
Verstuyf, A., Carmeliet, G., Bouillon, R., & Mathieu, C. (2010). Vitamin D: a pleiotropic hormone. Kidney Int., 78 (2), 140-145. DOI: 10.1038/ki.2010.17
Lai, Y.H., & Fang, T.C. (2013). The pleiotropic effect of vitamin D. ISRN Nephrol., 2013, 898125. DOI: 10.5402/2013/898125.
Censani, M., Hammad, H.T., Christos, P.J., & Schumaker, T. (2018). Vitamin D deficiency associated with markers of cardiovascular disease in children with obesity. Glob. Pediatr. Health., 5, 2333794X17751773. DOI: 10.1177/2333794X17751773.
Wolden-Kirk, H., Overbergh, L., Christesen, H.T., Brusgaard, K., & Mathieu, C. (2011). Vitamin D and diabetes: its importance for beta cell and immune function. Mol. Cell Endocrinol., 347 (1-2), 106-120. DOI: 10.1016/j.mce.2011.08.016.
Altieri, B., Grant, W.B., Della Casa, S., Orio, F., Pontecorvi, A., Colao, A., et al. (2017). Vitamin D and pancreas: The role of sunshine vitamin in the pathogenesis of diabetes mellitus and pancreatic cancer. Crit. Rev. Food. Sci. Nutr., 57 (16), 3472-88. DOI: 10.1080/10408398.2015.1136922.
Pankiv, V.I., Povoroznyuk, V.V., Pankiv, I.V., Boiko, V.I., & Hluhovska, S.V. (2019). Stan zabezpechennia vitaminom D naselennia Zakhidnoho rehionu Ukrainy [Vitamin D status in the population of the Western region of Ukraine]. Mizhnarodnyi endokrynolohichnyi zhurnal – International Journal of Endocrinology, 3, 268-271. DOI: http://dx.doi.org/10.22141/2224-0721.15.3.2019.172115 [in Ukrainian].
Spiro, A., & Buttriss, J.L. (2014). Vitamin D: An overview of vitamin D status and intake in Europe. Nutr Bull., 39 (4), 322-350. DOI: 10.1111/nbu.12108.
Braegger, C., Campoy, C., Colomb, V., Decsi, T., Domellof, M., Fewtrell, M., et al. (2013). Vitamin D in the healthy European paediatric population. J. Pediatr. Gastroenterol. Nutr., 56 (6), 692-701. DOI: 10.1097/MPG.0b013e31828f3c05.
Elamin, M.B., Abu Elnour, N.O., Elamin, K.B., Fatourechi, M.M., Alkatib, A.A., & Almandoz, J.P., et al. (2011). Vitamin D and cardiovascular outcomes: a systematic review and meta-analysis. J. Clin. Endocrinol. Metab., 96 (7), 1931-1942.
Lim, K., Hamano, T., & Thadhani, R. (2018). Vitamin D and Calcimimetics in Cardiovascular Disease. Semin Nephrol., 38 (3), 251-266.
Holik, MF. (2017). The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention. Rev. Endocr. Metab. Disord., 18 (2), 153-165. DOI: 10.1007/s11154-017-9424-1.
Pike, J.W., & Christakos, S. (2017). Biology and Mechanisms of Action of the Vitamin D Hormone. Endocrinol. Metab. Clin. North Am., 46 (4), 815-843. DOI: 10.1016/j.ecl.2017.07.001.
Povoroznyuk, V.V., & Balatska, N.I. (2012). Defitsyt vitaminu D u naselennia Ukrainy ta faktory ryzyku yoho rozvytku [Vitamin D deficiency in the population of Ukraine and risk factors for its development]. Bil. Suhloby. Khrebet – Pain. Joints. Spine, 4 (8), 5-11 [in Ukrainian].
Rochel, N., & Molnar, F. (2017). Structural aspects of Vitamin D endocrinology. Mol. Cell Endocrinol., 453, 22-35. DOI: 10.1016/j.mce.2017.02.046.
Carlberg, C. (2017). Molecular endocrinology of vitamin D on the epigenome level. Mol. Cell Endocrinol., 453, 14-21. DOI: 10.1016/j.mce.2017.03.016.
Shulhai, A.-M., Pavlyshyn, H.A., & Shulhai, O.M. (2019). Peculiarities of the prevalence and risk factors for vitamin D deficiency in overweight and obese adolescents in Ukraine. Arch. Balk Med. Union., 54 (1), 57-63. DOI: 10.31688/ABMU.2019.54.1.08.
Shulhai, A.M., Pavlyshyn, H., & Shulhai, O. (2019). Relation of carbohydrate exchange markers with vitamin D status in adolescents with overweight and obesity. Pediatr. Endocrinol. Diabetes Metab., 25 (4), 169-176. DOI: 10.5114/pedm.2019.89640.
Shulhai, A.-M., Pavlyshyn, H., & Shulhai, O. (2019). Metabolic disorders in adolescents with overweight and obesity. XXXV Zjazd Polskiego Towarzhystwa Pediatrycznego; In: Mazur A, ed. Rzeszow, Poland. Rzeszow: Grupa Medica; 2019.
Cheng, L. (2018). The convergence of two epidemics: vitamin D deficiency in obese school-aged children. J. Pediatr. Nurs., 38, 20N6. DOI: 10.1016/j.pedn.2017.10.005.
Reis, J.P., von Mühlen, D., Miller, E.R. 3rd, Michos, E.D., & Appel, L.J. (2009). Vitamin D status and cardiometabolic risk factors in the United States adolescent population. Pediatrics, 124 (3), 371n9. doi: 10.1542/peds.2009-0213.
Vierucci, F., Del Pistoia, M., Fanos, M., Gori, M., Carlone, G., Erba P, & Saggese, G. (2013). Vitamin D status and predictors of hypovitaminosis D in Italian children and adolescents: a cross-sectional study. Eur. J. Pediatr., 172 (12), 1607-1617. DOI: 10.1007/s00431-013-2119-z.
Greene-Finestone, L.S., Garriguet, D., Brooks, S., Langlois, K., & Whiting, S.J. (2017). Overweight and obesity are associated with lower vitamin D status in Canadian children and adolescents. Paediatr Child Health, 22 (8), 438d44. DOI: 10.1093/pch/pxx116.
Dura-Trave, T., Gallinas-Victoriano, F., Chueca-Guindulain, M.J., & Berrade-Zubiri, S. (2017). Prevalence of hypovitaminosis D and associated factors in obese Spanish children. Nutr. Diabetes., 7 (3), e248. DOI: 10.1038/nutd.2016.50.
Kaddam, I.M., Al-Shaikh, A.M., Abaalkhail, B.A., Asseri, K.S., Al-Saleh, Y.M., Al-Qarni, A.A., …, & Mukhtar, A.M. (2017). Prevalence of vitamin D deficiency and its associated factors in three regions of Saudi Arabia. Saudi Med. J., 38 (4), 381n90. DOI: 10.15537/smj.2017.4.18753.
Turer, С., Lin, H., & Flores, G. (2013). Prevalence of Vitamin D deficiency among overweight and obese US children. Pediatrics, 131 (1), 152-161.
Datta, S., Pal, M., & DE, A. (2014). The dependency of vitamin d status on anthropometric data. Malays J. Med. Sci., 21 (3), 54-61.
Vanlint, S. (2013). Vitamin D and obesity. Nutrients., 5 (3), 949-956. DOI: 10.3390/nu5030949.
Moore, C.E., & Liu, Y. (2017). Elevated systolic blood pressure of children in the United States is associated with low serum 25-hydroxyvitamin D concentrations related to body mass index: National Health and Examination Survey 2007-2010. Nutr. Res., 38, 64‐70.
McMullan, C.J., Borgi, L., Curhan, G.C., Fisher, N., & Forman, J.P. (2017). The effect of vitamin D on renin-angiotensin system activation and blood pressure: a randomized control trial. J. Hypertens, 35 (4), 822-829. DOI: 10.1097/HJH.0000000000001220.
Menezes, A.R., Lamb, M.C., Lavie, C.J., & DiNicolantonio, J.J. (2014). Vitamin D and atherosclerosis. Curr. Opin. Cardiol., 29 (6), 571-577.
Lavie, C.J., Dinicolantonio, J.J., & Milani, R.V. (2013). Vitamin D and cardiovascular health. Circulation, 128, 2404-2406.
Pelham, C.J., Drews, E.M., & Agrawal, D.K. (2016). Vitamin D controls resistance artery function through regulation of perivascular adipose tissue hypoxia and inflammation. J. Mol. Cell Cardiol., 98, 1110. DOI: 10.1016/j.yjmcc.2016.06.067.
Komisarenko, Yu.I. (2013). Vitamin D ta yoho rol u rehuliatsii metabolichnykh rozladiv pry tsukrovomu diabeti [Vitamin D and its role in the regulation of metabolic disorders in diabetes]. Liky Ukrainy – Medicines of Ukraine, 4, 51-54 [in Ukrainian].
Holick, M. (2013). Vitamin D – effects on skeletal and extraskeletal health and the need for supplementation. Nutrients, 5 (1), 111-148.
Mitri, J., Muraru, M.D., & Pittas, A.G. (2011). Vitamin D and type 2 diabetes: A systematic review. Eur. J. Clin. Nutr., 65, 1005-1015. DOI: 10.1038/ejcn.2011.118.
Lips, P., Eekhoff, M., van Schoor, N., Oosterwerff, M., de Jongh, R., Krul-Poel, Y., et al. (2017). Vitamin D and type 2 diabetes. J. Steroid Biochem. Mol. Biol., 173, 280o85. DOI: 10.1016/j.jsbmb.2016.11.021.
Wimalawansa, S.J. (2018). Associations of vitamin D with insulin resistance, obesity, type 2 diabetes, and metabolic syndrome. J. Steroid Biochem. Mol. Biol., 175, 177-189.
Jung, U.J., & Choi, M.S. (2014). Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease. Int. J. Mol. Sci., 15 (4), 6184o223. DOI: 10.3390/ijms15046184.
Al-Hamad, D., & Raman, V. (2017). Metabolic syndrome in children and adolescents. Transl. Pediatr., 6 (4), 397-407. DOI: 10.21037/tp.2017.10.02.
Agudelo, G.M., Bedoya, G., Estrada, A., Patiño, F.A., Muñoz, A.M., & Velásquez, C.M. (2014). Variations in the prevalence of metabolic syndrome in adolescents according to different criteria used for diagnosis: which definition should be chosen for this age group? Metab. Syndr. Relat. Disord., 12, 202-209. DOI: 10.1089/met.2013.0127.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Actual Problems of Pediatrics, Obstetrics and Gynecology
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish in this journal agree to the following terms:
1. The authors reserve the right to authorship of the work and pass the journal right of first publication of this work is licensed under a Creative Commons Attribution License, which allows others to freely distribute the work published with reference to the authors of the original work and the first publication of this magazine.
2. Authors are entitled to enter into a separate agreement on additional non-exclusive distribution of work in the form in which it was published in the magazine (eg work place in the electronic repository institution or publish monographs in part), provided that the reference to the first publication of this magazine.
3. Policy magazine allows and encourages authors placement on the Internet (eg, in storage facilities or on personal websites) manuscript of how to submit the manuscript to the editor and during his editorial processing, since it contributes to productive scientific discussion and positive impact on the efficiency and dynamics of citing published work (see. The Effect of Open Access).