VITAMINS B AND HOMOCYSTEINE IN THE SERUM OF CHILDREN WITH CARDIAC SYNCOPE
DOI:
https://doi.org/10.11603/24116-4944.2021.1.12347Keywords:
vitamin B6, folic acid, vitamin B12, homocysteine, cardiac syncope, childrenAbstract
The aim of the study – to investigate vitamin B6, folic acid, vitamin B12 and homocysteine levels in the serum of children with cardiac syncope and to determine their relationships with indicators of cardiovascular system functioning.
Materials and Methods. 19 children with cardiac syncope and 23 practically healthy children aged 8–17 years were examined. Cardiac syncope was diagnosed using criteria of the European Society of Cardiology (2018). Serum vitamins B6, B9, B12 and homocysteine levels were determined by colorimetric enzyme-linked immunosorbent assay using the Monobind test system (USA). 24-hour Holter monitoring and 24-hour ambulatory blood pressure monitoring were provided for all patients.
Results and Discussion. Serum vitamins B6, B9 and B12 levels in children with cardiac syncope were not differ from healthy children (p>0.05). The correlations between vitamin B6 and systolic blood pressure during day (r=0.62), folic acid and the number of syncope episodes in the anamnesis (r=-0.49), vitamin B12 and the average duration of QTc interval (r=0.49), vitamin B12 and the heart rate variability parameter LF/HF (r=0.46) are evidence of possible role of these vitamins in the pathogenesis of cardiac syncope (p<0.05). Compared with the control group, children with cardiac syncope had a significantly higher rate of serum homocysteine (15.30±1.23; 7.81±1.71 μmol/l; p<0.05).
Conclusions. Cardiac syncope in children is characterized by high homocysteine level on the background of reference vitamins B6, B9, B12 values. The prevalence of hyperhomocysteinemia is 72.2% in the group of cardiac syncope.
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