SPERM DNA FRAGMENTATION: CAUSES, MECHANISM, INFLUENCE ON THE ONSET AND CARRYING A PREGNANCY

Authors

  • S. V. Khmil Medical Center “Сlinic of Prof. Stefan Khmil” “I. Horbachevsky Ternopil National Medical University”
  • O. Yu. Mayorova Medical Center “Сlinic of Prof. Stefan Khmil” Volodymyr Hnatiuk Ternopil National Pedagogical University
  • L. M. Malanchuk “I. Horbachevsky Ternopil National Medical University”
  • М. S. Khmil Medical Center “Сlinic of Prof. Stefan Khmil” “I. Horbachevsky Ternopil National Medical University”
  • A. S. Khmil-Dosvald Medical Center “Сlinic of Prof. Stefan Khmil” “I. Horbachevsky Ternopil National Medical University”
  • I. V. Dudchuk Medical Center “Сlinic of Prof. Stefan Khmil”

DOI:

https://doi.org/10.11603/24116-4944.2020.2.11859

Keywords:

ejaculate, sperm DNA fragmentation, assisted reproductive technologies, pregnancy

Abstract

The aim of the study – to investigate the causes of sperm DNA fragmentation, to establish the relationship between DNA disruption and ejaculate quality, and to study the effect of sperm DNA fragmentation on the onset and carrying a pregnancy.

Materials and Methods. Bibliosemantic and analytical methods were used in the research.

Results and Discussion. During the study, 46 sources of modern foreign literature on sperm DNA fragmentation and its impact on the onset and delivery of pregnancy were analyzed.

Conclusions. Analysis of the literature showed that the level of sperm DNA fragmentation in the range of 15–30 % is statistically significant in terms of reducing positive pregnancy outcomes for in vivo, AMI, as well as in terms of increasing the risk of early miscarriage. If the level of DNA fragmentation of the partner’s sperm is> 30 %, IVF or ICSI will be the most effective methods of assisted reproductive technologies. However, the risk of developing fetal malformations associated with these assisted reproduction procedures should be borne in mind. Determining the level of DNA fragmentation can be used as a useful analysis in predicting miscarriages caused by male factor.

Author Biographies

S. V. Khmil, Medical Center “Сlinic of Prof. Stefan Khmil” “I. Horbachevsky Ternopil National Medical University”

MD, PhD, DSci, Professor, Merited figure of Science and Technology of Ukraine, Professor of the Department of Obstetrics and Gynecology No. 1 I. Horbachevsky Ternopil National Medical University, director of Medical Center «Professor Stefan Khmil Clinic»

O. Yu. Mayorova, Medical Center “Сlinic of Prof. Stefan Khmil” Volodymyr Hnatiuk Ternopil National Pedagogical University

Assistant Professor Department of Botany and Zoology, Volodymyr Hnatiuk Ternopil National Pedagogical University, Biologist of Medical Center «Professor Stefan Khmil Clinic»

L. M. Malanchuk, “I. Horbachevsky Ternopil National Medical University”

MD, PhD, DSci, Head of the Department of Obstetrics and Gynecology No. 1 I. Horbachevsky Ternopil National Medical University

М. S. Khmil, Medical Center “Сlinic of Prof. Stefan Khmil” “I. Horbachevsky Ternopil National Medical University”

Assistant of the Department of Obstetrics and Gynecology No. 1 I. Horbachevsky Ternopil National Medical University, medical director of the Medical Center «Professor Stefan Khmil Clinic»

A. S. Khmil-Dosvald, Medical Center “Сlinic of Prof. Stefan Khmil” “I. Horbachevsky Ternopil National Medical University”

Postgraduate student of the Department of Obstetrics and Gynecology No. 1 I. Horbachevsky Ternopil National Medical University, obstetrician-gynecologist, reproductive specialist of the Medical Center «Professor Stefan Khmil Clinic»

I. V. Dudchuk, Medical Center “Сlinic of Prof. Stefan Khmil”

biologist of Medical Center «Professor Stefan Khmil Clinic»

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Published

2021-03-04

How to Cite

Khmil, S. V., Mayorova, O. Y., Malanchuk, L. M., Khmil М. S., Khmil-Dosvald, A. S., & Dudchuk, I. V. (2021). SPERM DNA FRAGMENTATION: CAUSES, MECHANISM, INFLUENCE ON THE ONSET AND CARRYING A PREGNANCY. Actual Problems of Pediatrics, Obstetrics and Gynecology, (2), 173–178. https://doi.org/10.11603/24116-4944.2020.2.11859

Issue

No. 2 (2020)

Section

OBSTETRICS AND GYNECOLOGY

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