FEATURES OF THE CLINICAL COURSE OF VULVAR PRECANCER AND CANCER IN WOMEN OF PRE- AND POSTMENSTRUAL AGE
DOI:
https://doi.org/10.11603/24116-4944.2020.2.11856Keywords:
vulva, cancer, precancer, anamnesis, vulvoscopy, histological examinationAbstract
The aim of the study – to learn the features of the clinical course of precancerous lesions and vulvar cancer in pre- and postmenopausal women.
Materials and Methods. From 2017 to 2020, 160 patients with dystrophic diseases, precancerous lesions and early vulvar cancer were examined in the Outpatient Department of the National Cancer Institute. The analysis of outpatient cards and medical histories of all women allowed us to further study the features of the clinical course of pathological processes of the external genitalia depending on age. The age of patients in the study ranged from 49 to 70 years old (59.6±3.5). Menstrual function was unchanged in 40 (25 %) of 160 women. The age of menarche varied from 11 to 18 years (mean age – (14.5±0.3 years). The average duration of the menstrual cycle was (30±0.4) days. Most patients have repeatedly consulted gynecologists and dermatologists about itching and discomfort in the external genitalia. The doctor performed conservative treatment of ‘‘leukoplakia and kraurosis’’ for many months, and sometimes years, without histological clarification of the diagnosis.
Results and Discussion. In the study of vulvar biopsies, patients diagnosed with vulvar cancer stage IA (34 %) dominated comparing with VIN (intraepithelial neoplasia of the vulva) (12 %).
Conclusion. One of the features of the clinical course of vular neoplasia in women of pre- and postmenopausal age is that the malignant process is more often detected at the stage of monofocal invasive tumor.
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