EFFICACY OF CONTROLLED LONG PROTOCOL OVARIAL STIMULATION IN WOMEN WITH ENDOMETRIOSIS-ASSOCIATED INFERTILITY

Authors

  • S. V. Khmil I. Horbachevsky Ternopil National Medical University
  • I. I. Kulyk I. Horbachevsky Ternopil National Medical University

DOI:

https://doi.org/10.11603/24116-4944.2020.2.11846

Keywords:

infertility, endometriosis, controlled ovarian stimulation, efficacy

Abstract

The aim of the study – to analyze the effectiveness of controlled long protocol ovarian stimulation in women with infertility on the background of genitals endometriosis.

Materials and Methods. The study included 114 women aged 21 to 40 years with endometriosis-associated infertility. Patients with endometriosis-associated infertility were divided into subgroups: 1a – with monolateral endometrioid cysts; 1b – with bilateral endometrioid cysts; 2a – without recurrent cysts in the previously operated ovary; 2b – with mono- or bilateral cysts on the previously operated ovary. All patients used a "long" protocol of agonist-GnRH stimulation. Evaluation of aspirated oocytes was performed after denudation, before the ICSI procedure.

Results and Discussion. The lowest number of follicles was recorded in patients of groups 2a and 2b, which was probably less than the results of groups 1a (92.9 %) and 1b (78.6 %). During aspiration it was received significantly less oocytes in all experimental groups relative to the comparison group. The number of fertilized oocytes was the highest in the comparison group, in particular, it exceeded the data of groups 1a and 1b by 25.0 %, respectively, 2a and 2b groups by 200.0 %. In patients with infertility on the background of endometriosis, the yield of blastocysts was significantly lower in groups 1b, 2a and 2b relative to the data of the comparison group.

Conclusions. Long-term controlled ovarian stimulation using a GnRH agonist in women with endometriosis-associated infertility indicates a low efficacy in patients with a history of cystectomy vs in women with tubal-peritoneal infertility. The lowest number of pregnancies was found in women with endometriosis-associated infertility on the background of cystectomy.

Author Biographies

S. V. Khmil, I. Horbachevsky Ternopil National Medical University

Doctor of Medical Science, Professor, Merited Figure of Science and Technology of Ukraine, Professor Department of Obstetrics and Gynecology No. 1 I. Horbachevsky Ternopil National Medical University, Director of the Medical Center "Professor Stefan Khmil Clinic"

I. I. Kulyk, I. Horbachevsky Ternopil National Medical University

obstetrician-gynecologist, reproductive specialist of Medical Center "Professor Stefan Khmil Clinic"

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Published

2021-03-04

How to Cite

Khmil, S. V., & Kulyk, I. I. (2021). EFFICACY OF CONTROLLED LONG PROTOCOL OVARIAL STIMULATION IN WOMEN WITH ENDOMETRIOSIS-ASSOCIATED INFERTILITY. Actual Problems of Pediatrics, Obstetrics and Gynecology, (2), 100–105. https://doi.org/10.11603/24116-4944.2020.2.11846

Issue

No. 2 (2020)

Section

OBSTETRICS AND GYNECOLOGY

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