CONNECTIVE TISSUE HEART DYSPLASIA IN PREGNANT WOMEN AND PERINATAL CONSEQUENCES
(LITERATURE REVIEW AND OWN RESEARCH)
DOI:
https://doi.org/10.11603/24116-4944.2020.2.11841Keywords:
pregnancy, connective tissue dysplasia, idiopathic mitral valve prolapse, obstetric complicationsAbstract
The aim of the study – the role of connective tissue dysplasia of the heart with idiomatic mitral valve prolapse in the development of complications of pregnancy and childbirth in women, as well as the choice of optimal methods of pregnancy, prognosis, treatment and prevention of obstetric complications. The article presents modern world ideas about the influence of nonspecific connective tissue dysplasia of the heart on pregnancy, childbirth, fetal condition and postpartum period. Scientists from the world᾽s leading schools, who have achieved significant success in studying the problem of nonspecific connective tissue dysplasia over the last 10 years, state the global prevalence of dysplastic syndromes among young people, their significant impact on clinical manifestations and the course of most "common" diseases and 100 % dependence on adverse factors fetal period. Connective tissue is involved in key processes that determine the success of human reproduction. Mitral valve prolapse is considered to be one of the cardiac manifestations of connective tissue dysplasia syndrome (idiopathic or primary mitral valve prolapse), which has a proven genetic determination. Given the relatively high prevalence of mitral valve prolapse in the young population, the above complications are quite common (20–25 %) in pregnant women. Moreover, in pregnant women mitral valve prolapse is more severe, characterized by a higher incidence of various cardiovascular and obstetric complications, including a number of phenotypic and visceral heart abnormalities that can be inherited in children, which demonstrates the higher general clinical significance of the heart dysplasia problem just for pregnancy. The role of metabolic disorders, immune response, electrolyte imbalance, coagulopathy in the development of functional disorders of the life support systems of pregnancy and uterine-placental-fetal complex in women with connective tissue dysplasia of the heart and idiopathic mitral valve prolapse was detected. The analysis indicates the need for isolation in pregnant women with connective tissue dysplasia of the heart special clinical and biochemical markers for the prediction of obstetric and perinatal complications.
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