PECULIARITIES OF SEX HORMONE-BINDING GLOBULIN IN PUBERTAL GIRLS WITH DIFFUSE LIVER DISEASES
DOI:
https://doi.org/10.11603/24116-4944.2020.2.11831Keywords:
girls, puberty, diffuse liver diseases, sex hormone-binding globulinAbstract
The aim of the study – to evaluate the characteristics of the secretion of sex hormone-binding globulin (SHBG) in pubertal girls with diffuse liver diseases.
Materials and Methods. The study included 582 girls aged 12–17 years, of whom 402 with diffuse liver diseases (chronic viral hepatitis (n=120), non-alcoholic fatty disease (n=120), autoimmune hepatitis (n=30), fibrosis and cirrhosis (n=12), biliary dyskinesia (n=120)) and 180 conventionally somatically healthy girls with normal sexual development. After a comprehensive hepatological examination, the diagnosis of liver disease was made by a gastroenterologist. In the groups with liver diseases and healthy girls, the age groups from 12 to 17, inclusive, were evenly represented. The level of SHBG in venous blood was determined by the immunochemical method in the age groups 12, 13, 14, 15, 16 and 17 years old.
Results and Discussion. Among girls with diffuse liver diseases in all age categories, the highest level of SHBG was recorded in patients with chronic viral hepatitis, and the lowest in girls with liver cirrhosis. Low SHBG levels were also characteristic of girls with non-alcoholic fatty liver disease. It was found that the production of SHBG in puberty decreased with age in both somatically healthy girls and girls with diffuse liver diseases. However, the decrease in SHBG production in non-alcoholic fatty disease and liver cirrhosis was more pronounced than in healthy patients. In girls with biliary dyskinesia, there were no significant differences in SHBG levels and the rate of its decrease with age compared with similar indicators in controls.
Conclusions. SHBG levels are an indicator of liver dysfunction. SHBG can be an easily measurable and clinically useful biomarker for the early detection of children who may develop chronic diffuse liver disease in the future as well as obesity. Further research is needed to understand how SHBG is regulated in children.
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