INFLUENCE OF THYROID HORMONES AND DRUGS FOR ANESTHESIA ON FOLLATE METABOLISM IN RATS IN THE EXPERIMENT
DOI:
https://doi.org/10.11603/24116-4944.2020.1.11499Keywords:
homocysteine, foliac acid, hyperthyroidism, sodium thiopental, dexmedetomidineAbstract
The aim of the study – to determine the characteristics of the reaction of folate metabolism in experimental animals under conditions of simulated hyperthyroidism to the action of various drugs for anesthesia.
Material and Methods. To simulate the state of hyperthyroidism, rats were administered L-thyroxine for 21 days. The effect of euthyroidism and hyperthyroidism on the level of homocysteine and folic acid on the introduction of sodium thiopental and dexmedetomidine in the experiment was compared.
Results and Discussion. In the blood plasma of animals with experimental hyperthyroidism, changes in the level of homocysteine and folic acid were observed under the influence of sodium thiopental and dexmedetomidine hydrochloride under conditions of hyper- and euthyroidism.
Conclusions. Activation of metabolic processes of the thyroid gland affects the universal defense systems of the body, which is especially evident in conditions of operative and perioperative stress, folate metabolism, which causes an increased risk of thrombosis and the search for drugs to correct disturbed homeostasis.
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