ANALYSIS OF CLINICAL AND ANAMNESTIC DATA AND PREMORBID BACKGROUND IN ADENOMYOSIS
DOI:
https://doi.org/10.11603/24116-4944.2020.1.11493Keywords:
adenomyosis, premorbid background, anamnesis, risk factorsAbstract
The aim of the study – to learn the influence of clinical and medical history aspects, features of premorbid background on the formation and course of adenomyosis.
Materials and Methods. The study included 160 patients, 130 of whom were patients with adenomyosis of various degrees of spread (main group). The control group consisted of 30 healthy women. The average age of patients was (39.5±5.7). Clinical and anamnestic data and the state of the premorbid background and the results of a histological study were used.
Results and Discussion. Among patients with adenomyosis, a significant proportion are patients under the age of 35 years – 28.8 %, with menstrual irregularities (92.3 %) from the menarche period, according to the type of menorrhagia; endometrial pathology (endometrial polyps – 37.7 %, endometrial hyperplasia – 22.3 %); frequent curettage of the uterus (78.5 %); electrical excision of the cervix (65 %); the presence of childbirth (49.2 %), in 75 % of cases complicated by surgical interventions; gastrointestinal tract diseases (57.7 %). A burdened gynecological and somatic history with a low health index, a hereditary burden of tumorous diseases are contributing factors, and the high prevalence of previous surgical interventions and chronic inflammatory processes of the genitalia create a favorable background for the development and progression of adenomyosis.
Conclusions. A necessity of the detailed study of the characteristics of clinical and anamnestic data, premorbid background in patients with adenomyosis will allow doctors to predict and timely conduct pathogenetic therapy, which is especially important for patients of fertile age.
References
Zegers-Hochschild, F., Adamson, G.D., Dyer, S., Racowsky, C., de Mouzon, J., Sokol, R., …, & van der Poel, S. (2017). The international glossary on infertility and fertility care. Human. Reprod., 32 (9), 1786-1801. DOI: https://doi.org/10.1093/humrep/dex234
Seidman, J.D., & Kjerulff, K.H. (1996). Pathologic findings from the Maryland Women᾽s Health Study: practice patterns in the diagnosis of adenomyosis. Int. J. Gynecol. Pathol., 15 (3), 217-221. DOI: https://doi.org/10.1097/00004347-199607000-00005
Vercellini, P., Vigano, P., Somigliana, E., Daguati, R., Abbiati, A., & Fedele, L. (2006). Adenomyosis: epidemiological factors. Best. Pract. Res. Clin. Obstet. Gynaecol., 20 (4), 465-477. DOI: https://doi.org/10.1016/j.bpobgyn.2006.01.017
Vercellini P, Parazzini F, Oldani S, Panazza S, Bramante T, Crosignani PG, ..., & Oldani, S. (1995). Surgery: Adenomyosis at hysterectomy: a study on frequency distribution and patient characteristics. Human. Reprod., 10 (5), 1160-1162. DOI: https://doi.org/10.1093/oxfordjournals.humrep.a136111
Pinzauti, S., Lazzeri, L., Tosti, C., Centini, G., Orlandini, C., Luisi, S., …, & Petraglia, F. (2015). Transvaginal sonographic features of diffuse adenomyosis in 18–30-year-old nulligravid women without endometriosis: association with symptoms. Ultrasound Obstet. Gynecol., 46 (6), 730-736.
Chapron, C., Tosti, C., Marcellin, L., Bourdon, M., Lafay-Pillet, M.C., Millischer, A.E., …, & Santulli, P. (2017). Relationship between the magnetic resonance imaging appearance of adenomyosis and endometriosis phenotypes. Human. Reprod., 32 (7), 1393-1401. DOI: https://doi.org/10.1093/humrep/dex088
Strizhakov, A.N., & Davydov, A.I. (1996). Endometrioz. Klinicheskiye i teoreticheskiye aspekty [Endometriosis. Clinical and theoretical aspects]. Moscow: Meditsyna [in Russian].
Dzhamalutdinova, K.M., Kozachenko, I.F., Gus, A.I., & Adamyan, L.V. (2018). Sovremennyye aspekty patogeneza i diagnostiki adenomioza [The pathogenesis and diagnosis of adenomyosis: current aspects]. Akusherstvo i ginekologiya – Obstetrics and Gynecology, 1, 29-34. Retrieved from: https://doi.org/10.18565/aig.2018.1.29-34 [in Russian]. DOI: https://doi.org/10.18565/aig.2018.1.29-34
Horban, N.Y., Vovk, I.B., Lysiana, T.O., Ponomariova, I.H., & Zhulkevych, I.V. (2019). Peculiarities of uterine cavity biocenosis in patients with different types of endometrial hyperproliferative pathology. J. Med. Life, 12 (3), 266-270. DOI: 10.25122/jml-2019-0074. DOI: https://doi.org/10.25122/jml-2019-0074
Gorban, N.Y., Zadorozhna, T.D., Vovk, I.B., & Zhulkevych, I.V. (2019). Morphological features of uterine polyps in females of reproductive age. Visnyk naukovykh doslidzhen – Bulletin of Scientific Research, 2, 47-52. https://doi.org/10.11603/2415-8798.2019.2.10267 [in Ukrainian]. DOI: https://doi.org/10.11603/2415-8798.2019.2.10267
Kryvokulsky, B.D., Zhulkevych, I.V., Kryvokulsky, D.B., & Shkrobot, L.V. (2018). Vyvchennia vplyvu viku ta indeksu komorbidnosti na ryzyk trombotychnykh uskladnen u khvorykh na rak endometriia na dooperatsinomu etapi [Studying the influence of age and comorbidity index on the thrombotic complications risk in patients with endometrial cancer at preoperative stage]. Visnyk naukovykh doslidzhen – Bulletin of Scientific Research, 2, 151-153. https://doi.org/10.11603/2415-8798.2018.2.9212 [in Ukrainian]. DOI: https://doi.org/10.11603/2415-8798.2018.2.9212
Brun, J.-L., Botolahy, Z.A., Benjoar, M., Marty, M., & Bazot, M. (2014). Diagnosis of adenomyosis. EMC - Gynecology-Obstetrics, 50 (4), 1-10.
Lacheta, J. (2019). Uterine adenomyosis: Pathogenesis, diagnostics, symptomatology and treatment. Ceska Gynekologie, 84 (3), 240-246.
Martínez Camilo, R.V. (2015). Adenomyosis in climacteric women. Revista Cubana de Obstetricia y Ginecologia, 41 (3), 234-240.
Gordts, S., Grimbizis, G.F., & Campo, R. (2018). Symptoms and classification of uterine adenomyosis, including the place of hysteroscopy in diagnosis. Fertility and Sterility, 109 (3), 380-388. DOI: https://doi.org/10.1016/j.fertnstert.2018.01.006
Arutyunyan, A.F. (2017). Osobennosti dopplerometricheskikh pokazateley pri razlichnykh stepenyakh adenomioza [Features of dopplerometric indicators at various degrees of adenomyosis]. Zdorovye i obrazovaniye – Health and Education, 19, 10, 32-36 [in Russian].
Damirov, M.M. (2015). Sovremennaya taktika vedeniya bolnykh s adenomiozom: prakticheskoye rukovodstvo [Modern tactics of management of patients with adenomyosis: a practical guide]. Moscow: Iz-vo BINOM [in Russian].
Arutyunyan, A.F. (2018). Adenomioz: molekulyarno-geneticheskiye, immunologicheskiye i gemodinamicheskiye faktory razvitiya, taktika vedeniya [Adenomyosis: molecular genetic, immunological and hemodynamic development factors, management tactics]. Doctor᾽s thesis. Saint Petersburg [in Russian].
Arutyunyan, A.F., Gaidukov, S.N., & Kostyushov, V.E. (2015). Adenomyosis: Algorithms complex conservative treatment. Proceedings from: VIII International Research and Practice Conference. Munich, Germany.
Arutyunyan, A.F., Gaidukov, S.N., Pavlova, N.G., & Kostyushov, E.V. (2016). Transvaginal color doppler ultrasonography significance for prediction fibroids relapse after organ surgery on the uterus patients with adenomyosis. Proceedings from: VII International Scientific Conference. Chicago, USA.
Zhang, J., Yu, J., Zhang, D., & Xia, W. (2019). Treatment of adenomyosis by hysteroscope. J. Minim. Invasive Gynecol., 26 (7), s193.
Mikos, T., Lioupis, M., Anthoulakis, C., & Grimbizis, G.F. (2020). The outcome of fertility-sparing and nonfertility-sparing surgery for the treatment of adenomyosis: A systematic review and meta-analysis. J. Minim. Invasive Gynecol., 27 (2), 309-331.e3. DOI: https://doi.org/10.1016/j.jmig.2019.08.004
Choi, E.Ji., Cho, S.B., Lee, S.R., Lim, Y.M., Jeong, K., Moon, H.-S., & Chung, H. (2017). Comorbidity of gynecological and non-gynecological diseases with adenomyosis and endometriosis. Obstetrics & Gynecology Science, 60 (6), 579-586. DOI: https://doi.org/10.5468/ogs.2017.60.6.579
Che, X., Wang, J., He, J., Guo, X., Li, T., & Zhang, X. (2020). The new application of mifepristone in the relief of adenomyosis-caused dysmenorrhea. Int. J. Med. Sci., 17 (2), 224-233. Retrieved from: http://www.medsci.org/v17p0224.htm DOI: https://doi.org/10.7150/ijms.39252
Naftalin, J., Hoo, W., Pateman, K., Mavrelos, D., Holland, T., & Jurkovic, D. (2012). How common is adenomyosis? A prospective study of prevalence using transvaginal ultrasound in a gynaecology clinic. Hum. Reprod., 27, 3432-3439. DOI: https://doi.org/10.1093/humrep/des332
Garcia, L., & Isaacson, K. (2011). Adenomyosis: review of the literature. J. Minim. Invasive Gynecol., 18, 428-437. DOI: https://doi.org/10.1016/j.jmig.2011.04.004
Pinzauti, S., Lazzeri, L., Tosti, C., Centini, G., Orlandini, C., Luisi, S., …, & Petraglia, F. (2015). Transvaginal sonographic features of diffuse adenomyosis in 18-30-year-old nulligravid women without endometriosis: association with symptoms. Ultrasound Obstet. Gynecol., 46, 730-736. DOI: https://doi.org/10.1002/uog.14834
Puente J.M., Fabris A., Patel J., Patel A., Cerrillo M., Requena A., & Garcia-Velasco, J.A. (2016). Adenomyosis in infertile women: prevalence and the role of 3D ultrasound as a marker of severity of the disease. Reprod. Biol. Endocrinol., 14, 60. DOI: https://doi.org/10.1186/s12958-016-0185-6
Spitz, I.M., Grunberg, S.M., Chabbert-Buffet, N., Lindenberg, T., Gelber, H., & Sitruk-Ware, R. (2005). Management of patients receiving long-term treatment with mifepristone. Fertil. Steril., 84, 1719-1726. DOI: https://doi.org/10.1016/j.fertnstert.2005.05.056
Li, L., Leng, J., Jia, S., & Lang, J. (2019). Treatment of symptomatic adenomyosis with the levonorgestrel-releasing intrauterine system. Int. J. Gynaecol. Obstet., 146 (3), 357-363. DOI: https://doi.org/10.1002/ijgo.12887
Vargas, M.V., & Huang, K. (2019). Endometriosis and adenomyosis. Evidence-based Obstetrics and Gynecology. E. Norwitz, D. Miller, C. Zelop, D. Keefe (Eds.). Ch. 8. John Wiley & Sons, Ltd. Retrieved from: https://doi.org/10.1002/9781119072980.ch8. DOI: https://doi.org/10.1002/9781119072980.ch8
van den Bosch, V.T., Cornelis, A., van Schoubroeck, D., van Pachterbeke, C., & Timmerman, D. (2014). OP 16.08: Three-dimensional (3D) in vitro ultrasound examination in adenomyosis. Ultrasound in Obstetrics & Gynecology., 44 (1), 113.
Downloads
Published
How to Cite
Issue
Section
License
Authors who publish in this journal agree to the following terms:
1. The authors reserve the right to authorship of the work and pass the journal right of first publication of this work is licensed under a Creative Commons Attribution License, which allows others to freely distribute the work published with reference to the authors of the original work and the first publication of this magazine.
2. Authors are entitled to enter into a separate agreement on additional non-exclusive distribution of work in the form in which it was published in the magazine (eg work place in the electronic repository institution or publish monographs in part), provided that the reference to the first publication of this magazine.
3. Policy magazine allows and encourages authors placement on the Internet (eg, in storage facilities or on personal websites) manuscript of how to submit the manuscript to the editor and during his editorial processing, since it contributes to productive scientific discussion and positive impact on the efficiency and dynamics of citing published work (see. The Effect of Open Access).
