THE ROLE OF LIPID METABOLISM DISORDERS IN THE ABNORMAL UTERINE BLEEDING IN REPRODUCTIVE AGE WOMEN

Authors

  • V. M. Zaporozhan Odessa National Medical University, Odessa
  • N. M. Rozhkovska Odessa National Medical University, Odessa
  • V. G. Marichereda Odessa National Medical University, Odessa
  • I. S. Lomakina Odessa National Medical University, Odessa

DOI:

https://doi.org/10.11603/24116-4944.2020.1.11490

Keywords:

abnormal uterine bleeding, endometrial hyperplasia, receptors, expression, lipid profile, obesity

Abstract

The aim of the study – to assess the effect of lipid metabolism disorders on the risk of abnormal uterine bleeding in women of reproductive age.

Materials and Methods. Thirty women of reproductive age with abnormal uterine bleeding were examined. The expression of α-receptors for estrogen ER1, receptors for progesterone PgR and nuclear protein Ki-67 in the glands and stroma of the endometrium was performed by immunohistochemical method. Lipidogram parameters were evaluated, body mass index was determined, and anthropometry was performed.

Results and Discussion. When assessing nutritional status, the prevalence among patients of BMI> 25 kg/m2 was found to be 96.7 %, while signs of nutritional constitutional obesity were 33.3 %. The average BMI was (29.1±1.6) kg/m2. The expression of estrogen receptors ER1 was higher in the glands (Me (25 %; 75 %) = 100 (80; 100) than in the stroma (Me (25 %; 75 %) = 80 (60; 90). On the other hand, the number of cells with a positive reaction to PgR progesterone receptors in the stroma and glands did not practically differ in Me (25 %; 75 %) = 80 (50, 90). The expression of Ki-67 protein was higher in glands – (ME (25 %; 75 %) =  90 (70; 100), in the stroma it did not exceed 50 % ((Me (25 %; 75 %) = 40 (30; 50).

Conclusions. 1. In patients with abnormal uterine bleeding, lipid disturbances in the form of type 2b dyslipidemia are often found. 2. The severity of dyslipidemia correlates with the intensity of abnormal uterine bleedings and the expression of proliferation markers.

Author Biographies

V. M. Zaporozhan, Odessa National Medical University, Odessa

Doctor of Medical Sciences, Professor of the Department of Obstetrics and Gynecology No. 1, Odessa National Medical University

N. M. Rozhkovska, Odessa National Medical University, Odessa

Doctor of Medical Sciences, Professor of Obstetrics and Gynecology No. 1, Odessa National Medical University

V. G. Marichereda, Odessa National Medical University, Odessa

Doctor of Medical Sciences, Professor of the Department of Obstetrics and Gynecology No. 1, Vice-Rector for Research, Odessa National Medical University

I. S. Lomakina, Odessa National Medical University, Odessa

obstetrician-gynecologist, post-graduate student of the Department of Obstetrics and Gynecology No. 1, Odessa National Medical University

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Published

2020-11-03

How to Cite

Zaporozhan, V. M., Rozhkovska, N. M., Marichereda, V. G., & Lomakina, I. S. (2020). THE ROLE OF LIPID METABOLISM DISORDERS IN THE ABNORMAL UTERINE BLEEDING IN REPRODUCTIVE AGE WOMEN. Actual Problems of Pediatrics, Obstetrics and Gynecology, (1), 80–84. https://doi.org/10.11603/24116-4944.2020.1.11490

Issue

No. 1 (2020)

Section

OBSTETRICS AND GYNECOLOGY

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