USE EXPERIENCE OF RATIONAL ANTIBACTERIAL THERAPY IN THE TREATMENT OF NEWBORNS IN THE INTENSIVE CARE UNIT
DOI:
https://doi.org/10.11603/24116-4944.2020.1.11482Keywords:
newborns, antibacterial therapy, department of anesthesiology and intensive care of newborns, Gram-positive microorganisms, Gram-negative microorganismsAbstract
The aim of the study – to establish the quantitative and qualitative composition of the microflora of the upper respiratory tract of newborn patients and to determine its sensitivity to antibacterial drugs.
Materials and Methods. A microbiological study of cultures from the upper respiratory tract and determination of the sensitivity of the microflora to antibacterial drugs in 201 patients who were hospitalized and treated in the Department of Anesthesiology and Intensive Care of Newborns of the City Children’s Hospital No. 5 in Zaporizhzhia. The studies were performed during the hospitalization of the patient to the department, then inoculations were performed every 7 days.
Results and Discussion. Sufficient sensitivity of Gram-positive microorganisms, which prevailed in inoculation at all stages of the study, was found to vancomycin, some carbopenems, linezolid, clindamycin throughout the study. The study of Gram-negative microflora sensitivity to antibiotics revealed a high sensitivity to modern protected penicillins, carbapenems, aminoglycosides, fluoroquinolones, and in the study of sensitivity in repeated inoculations, repeated susceptibility was observed to carbapenems, aminoglycosides.
Conclusions. Gram-positive microorganisms predominated in microbiological studies, both in hospitalization and in secondary studies. The use of antibacterial therapy taking into account the sensitivity of the flora is the key to faster improvement of clinical and biological parameters of the patient and, as a consequence, reduce the length of stay in the intensive care unit.
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