ANALYSIS OF THE EFFICIENCY OF MEASURE VACCINATION IN CHILDREN WITH FOOD SENSITIZATION
DOI:
https://doi.org/10.11603/24116-4944.2020.1.11480Keywords:
children, measles, vaccination, food sensitization, vaccine, immunoglobulinsAbstract
The aim of the study – to analyze the efficiency of vaccination against measles and to study the peculiarities of the post-vaccination period in children with CS 1 and 6 months after vaccination.
Materials and Methods. 41 children 11–12 months aged were examined: group 1 – 18 children without clinical signs of CS (relatively healthy), group 2 – 23 children with clinical signs of CS. Conducted examinations: general clinical (full blood count, urine analysys), determination of levels of immunoglobulins (Ig) A, M, G before and 1 month after vaccination, IgG against measles 6 months after vaccination. All children are vaccinated with a live combination vaccine to prevent measles, mumps and rubella at the age of 12–13 months.
Results and Discussion. In both groups the course of the postvaccination process was satisfactory, there were no severe complications such as anaphylactic reaction or toxic erythema. Children with CS before vaccination had reduced level of IgG and IgM, Ig A compared with healthy and 1 month after vaccination in children with CS, IgG probably became higher than in healthy people, IgM and Ig A after vaccination in children with CS probably became higher than before vaccination. Six months after vaccination, 89 % of healthy children had a positive result of anti-measles IgG (IgG> 1.1) and 74 % of children with clinical signs of CS, which is 15 % less.
Сonclusions. Thus, measles vaccination in 74 % of children with CS is effective that is evidenced by a sufficient level of IgG 6 months after vaccination. Children who remain seronegative after the first dose of the vaccine should receive a booster dose. Children with clinical signs of CS did not have any complications after live combination vaccination.
References
Kramarov, S.O., Yevtushenko, V.V., Kovalokh, I.Yu., Kaminska, T.M., & Golovach, O.V. (2018). Klinichna kartyna koru v ditei, hospitalizovanykh pid chas spalakhu 2017-2018 rr. [Clinical features of measles in children hospitalized during 2017-2018 outbreak]. Aktualna infektolohiia – Actual Infectology, 6, 5, 240-245 [in Ukrainian].
Trykhlib, V.I., Shchur, A.B., Hrushkevych, V.V., Hryshyn, O.S., Pavlovska, M.O., Musiienko, T.I., & Kozachenko, L.V. (2018). Osoblyvosti klinichnykh proiaviv ta perebihu koru [Peculiarities of measles clinical manifestations and course]. Aktualna infektolohiia – Actual Infectology, 6, 3, 141-152 [in Ukrainian].
Wendorf, K., Winter, K., Zipprich, J., Schechter, R., Hacker, J., Preas, C., …, & Harriman, K. (2017). Subacute sclerosing panencephalitis: The devastating measles complication that might be more common than previously estimated. Clinical Infectious Diseases, 65 (2), 226-232. DOI: https://doi.org/10.1093/cid/cix302
Jackson, B., & Black, R. (2017). Available studies fail to provide strong evidence of increased risk of diarrhea mortality due to measles in the period 4-26 weeks after measles rash onset. BMC Public Health, 17 (S4), 783. DOI: https://doi.org/10.1186/s12889-017-4745-2
Marusik, I.I. (2017). Kir u ditei [Measles in children]. Aktualna infektolohiia – Actual Infectology, 5, 3, 129-133 [in Ukrainian].
Prokopiv, O.V., Myshenyuk, S.A., & Prykuda, N.M. (2019). Nevrolohichni uskladnennia koru u ditei [Neurological complications of measles in children]. Infektsiini khvoroby – Infectious Diseases, 1 (95), 14-19 [in Ukrainian].
Smyrnova, D.D., Usachova O.V., & Firiulina, O.M. (2019). Osoblyvosti perebihu koru v epidsezoni 2017-2018 rr. – rozvytok asotsiiovanoho z virusom koru urazhennia pechinky [Peculiarities of measles in the epidemiological season 2017-2018 – development of measles virus-associated liver damage]. Infektsiini khvoroby – Infectious Diseases, 1 (95), 20-25 [in Ukrainian].
Laksono B.M., de Vries R.D., McQuaid S., Duprex W.P., & de Swart Ri.L. (2016). Measles virus host invasion and pathogenesis. Viruses, 8 (8), 210. DOI: https://doi.org/10.3390/v8080210
Yevtushenko, V.V., Kramarov, S.О., Shadrin, V.O., Markov, A.I., Kaminska, T.M., & Hrechukha, Ye.O. (2019). Klinichni ta epidemiolohichni osoblyvosti koru v hospitalizovanykh ditei pid chas dvokh spalakhiv (2005–2006 i 2017–2018 rokiv) v Ukraini [Clinical and epidemiological features of measles in children hospitalized during two outbreaks (2005–2006 and 2017–2018) in Ukraine]. Zaporizkyi medychnyi zhurnal – Zaporizhzhia Medical Journal, 21, 6 (117), 808-814 [in Ukrainian].
Ryabokon, Yu.Yu., Bilokobyla, S.O., & Ryabokon, O.V. (2019). Suchasnyi perebih koru v doroslykh (ohliad literatury) [Modern course of measles in adults (literature review)]. Zaporizkyi medychnyi zhurnal – Zaporizhzhia Medical Journal, 21, 5 (116), 697-701 [in Ukrainian].
Daragan, G.M., Krushynska, T.Yu., Stepanskyi, D.O., Demchyshyna, I.V., & Kolesnikova, I.P. (2018). Aktualni pytannia vaktsynatsii ta epidemiolohichnoho nahliadu za korom i krasnukhoiu v Ukraini [Problematics of proving the fact of occupational TB in health care workers]. Medychni perspektyvy – Medical Perspectives, 3, 38-43 [in Ukrainian].
Bondarenko, A.M. (2019). Vaktsynatsiia – otsinka dotsilnosti ta ryzykiv [Vaccination assessment of feasibility and risks]. Infektsiini khvoroby – Infectious Diseases, 2 (96), 75-95 [in Ukrainian].
Ishhuk, I.S., & Stetsyuk, I.O. (2018). Vaktsynatsiia proty koru yak efektyvna profilaktyka vynyknennia zakhvoriuvannia [Measles vaccination as effective prophylaxis of the disease]. Infektsiini khvoroby – Infectious Diseases, 3 (93), 57-61 [in Ukrainian].
Grammens, T., Schirvel, C., Leenen, S., Shodu, N., Hutse, V., Mendes da Costa, E., & Sabbe, M. (2017). Ongoing measles outbreak in Wallonia, Belgium, December 2016 to March 2017: characteristics and challenges. Eurosurveillance, 22 (17). DOI: https://doi.org/10.2807/1560-7917.ES.2017.22.17.30524
Santibanez, S., Hübschen, J.M., Ben Mamou, M.C., Muscat, M., Brown, K.E., Myers, R., …, & Mankertz, A. (2017). Molecular surveillance of measles and rubella in the WHO European Region: new challenges in the elimination phase. Clin. Microbiol Infect., 23 (8), 516-523. DOI: https://doi.org/10.1016/j.cmi.2017.06.030
Toptygina, A.P., Smerdova, M.A., Naumova, M.A., Vladimirova, N.P., & Mamaeva, T.A. (2018). Vliyaniye osobennostey populyatsionnogo immuniteta na strukturu zabolevayemosti koryu i krasnukhoy [Influence of population immunity peculiarities on the structure of measles and rubella prevalence]. Infektsiya i immunitet – Russian Journal of Infection and Immunity, 8 (3), 341-348 [in Russian]. DOI: https://doi.org/10.15789/2220-7619-2018-3-341-348
Nikiforov, A.Yu., Kostyukova, T.L., Nagayeva, S.Yu., Vinogradov, A.F., & Sizhenkova, L.P. (2019). Kor u rebenka: klinicheskiy sluchay [Measles in a child: A clinical case]. Voprosy sovremennoy pediatrii – Current Pediatrics, 18, 5, 369-373 [in Russian].
Chernaya, N.L., Solondaev, V.K., Koneva, Ye.V., Batorshina, S.Ye., & Dadaeva, O.B. (2016). Vynuzhdennoye resheniye roditeley o privivkakh kak psikhologicheskaya «pochva» antivaktsinalnykh ustanovok [Forced parents decision of vaccination as a psychological ground for an anti-vaccination paradigm]. Voprosy sovremennoy pediatrii – Current Pediatrics, 15, 2, 168-174 [in Russian]. DOI: https://doi.org/10.15690/vsp.v15i2.1535
Artemova, I.V., & Kulichenko, T.V. (2017). Epidemiya kori. Realna li ugroza? [A measles outbreak. Is the threat real?] Voprosy sovremennoy pediatrii – Current Pediatrics, 16, 5, 358-361 [in Russian].
Chernyshova L.I., Lapii, F.I., Volokha, A.P., Bondarenko, A.V., Stepanovskyi, Yu.S., & Hilfanova, A.M. (2019). Imunoprofilaktyka infektsiinykh khvorob: navch.-metod. posib. [Immunoprophylaxis of infectious diseases: teaching method way]. Chernyshova, L.I., Lapii, F.I., Volokha, A.P. Eds. 2nd edn., revised and suppl. Kyiv: VSV “Medytsyna” [in Ukrainian].
Snegova, N.F., Kostinov, M.P., Pakhomov, D.V., & Ilyina, N.I. (2018). Vaccination against measles in children born to HIV-infected mothers (clinical and immunological aspects). Infektsiya i immunitet – Russian Journal of Infection and Immunity, 2, 325-336.
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