THE ROLE OF POLYMORPHISM OF INDIVIDUAL GENES IN THE FORMATION OF BRONCHIAL ASTHMA IN CHILDREN
DOI:
https://doi.org/10.11603/24116-4944.2020.1.11476Keywords:
children, bronchial asthma, tumor necrosis factor, polymorphism, genesAbstract
The aim of the study – to determine the effect of G308A polymorphism of the tumor necrosis factor-alpha (TNFα) gene on the formation of bronchial asthma (BA) in children.
Materials and Methods. The G308A polymorphism of the tumor necrosis factor-alpha (TNFα) gene was studied in 101 children with asthma.
Results and Discussion. It was found that asthma more often had early debut (in 64.36 % of cases the diagnosis had been confirmed during first six years of life). In the study of G308A polymorphism of TNFα gene production in patients was established the prevalence of G/G (n = 69) genotype. In the case of the surveyed burdened family history for asthma, was noticed the genotype G/G (on the maternal line – in 74.36 % of cases and in 70.00 % – according to paternal line), less often G/A genotype of G308A TNFα ( in 20.51 % and 30.00 % respectively). The monozygotic variant of GG for the major allele (70.42 %) was mostly diagnosed. After analyzing the peculiarities of the occurrence of asthma in children, it was found that in patients with the implementation of an allergic march dominated G/G genotype of the TNFα gene (34.78 %) and each fourth child had the G/A genotype. Children with BA, like first and only one form of allergic pathology, had a homozygous variant of G/G domination for the main allele of the TNFα gene (76.92 %).
Conclusions. 1. The dominant genotype G/G G308A TNFα in children with asthma is established in the case of early onset of the disease, processing the genetic history and despite the severity of the course. 2. Molecular genetic study of the TNFα gene polymorphism can be applied for forming groups of risk and assessment of control over the course of BA.
References
Gang, L., Flory, L.N., Bryan, L.S., Darell, S., & Johnson, M.D. (2015). A systematic review of predictive models for asthma development in сhildren. BMC Med. Inform. Decis. Mak., 15, 99. DOI:10.1186/s12911-015-0224-9. DOI: https://doi.org/10.1186/s12911-015-0224-9
Banadyha, N.V. (2018). Henotypovi osoblyvosti perebihu riznykh fenotypiv bronkhialnoi astmy u ditei [Genotypic features of different phenotypes of bronchial asthma in children]. Sovremennaya pediatriya – Modern Pediatrics, 6, 9-13 [in Ukrainian].
Benedictis, F.M., & Attanasi, M. (2016). Asthma in childhood. Eur. Respir. Rev., 25 (139), 41-47. DOI:10.1183/16000617.0082-2015. DOI: https://doi.org/10.1183/16000617.0082-2015
Zhang, Y., Li, T., Yuan, H., Pan, W., & Dai, Q. (2018). Correlations of inflammatory factors with intestinal flora and gastrointestinal incommensurate symptoms in children with asthma. Med. Sci. Monit., 24, 7975-7979. DOI:10.12659/MSM.910854. DOI: https://doi.org/10.12659/MSM.910854
Kim, H., Ellis, A.K, Fischer, D., Olivenstein, M.R., Chapman, K.R., & Lee, J. (2017). Asthma biomarkers in the age of biologics. Allergy Asthma Clin. Immunol., 13, 48. DOI:10.1186/s13223-017-0219-4. DOI: https://doi.org/10.1186/s13223-017-0219-4
Kupczyk, M., Bartuzi, Z., Bodzenta-Łukaszyk, A., Kulus, M., Kuna, P., Kupryś-Lipińska, I., & Mazurek, H. (2019). Polish Society of Allergology statement on the diagnosis and treatment of severe, difficult-to-control bronchial asthma. Postepy Dermatol. Alergol., 36 (2), 147-157. DOI:10.5114/ada.2019.84591. DOI: https://doi.org/10.5114/ada.2019.84591
Garas, M., Sazhyn, S., Lekhkun, G., Goncharuk, R., Gorenko, N. (2018). Indices of nonspecific bronchial reactivity in severe asthma phenotype determination in schoolchildren. Wiad. Lek., 71 (8), 1537-1540.
Voronina, E.V., Lobanova, N.V., Yakhin, I.R., Romanova, N.A., & Seregin, Y.A. (2018). Role of tumor necrosis factor alpha in immune pathogenesis of different diseases and its significance for evolving anticytokine therapy with monoclonal antibodies. Meditsinskaya immunologiya – Medical Immunology, 20 (6), 797-806. DOI.org/10.15789/1563-0625-2018-6-797-806. 9. Babusikova, E., Jurecekova, J., Jesenak, M., & Evinova, A. (2017). Association of gene polymorphisms in interleukin 6 in infantile bronchial asthma. Arch. Bronconeumol., 53 (7), 381-386. DOI:10.1016/j.arbres.2016.09.012. DOI: https://doi.org/10.1016/j.arbres.2016.09.012
Çelebi Sözener, Z., Çiftci, F., Aydın, Ö., & Mungan, D. (2018). Relation of systemic comorbidities in asthma with disease: control, severity and phenotype. Tuberk Toraks., 66 (4), 288-296. DOI:10.5578/tt.67629. DOI: https://doi.org/10.5578/tt.67629
Lin, Sh.-Ch., Shi, L.-Sh., & Ye, Y.-L. (2019). Advanced molecular knowledge of therapeutic drugs and natural products focusing on inflammatory cytokines in asthma. Cells., 8 (7), 685. DOI:10.3390/cells8070685. DOI: https://doi.org/10.3390/cells8070685
Klaassen, E.M., Penders, J., Jöbsis, Q., Kant, K.D., Thijs, C., Mommers, M., & Schayck, C.P. (2015). An ADAM33 Polymorphism associates with progression of preschool wheeze into childhood asthma: A prospective case-control study with replication in a birth cohort study. PLoS One., 10 (3), e0119349. DOI:10.1371/journal.pone.0119349. DOI: https://doi.org/10.1371/journal.pone.0119349
Lee, E., Lee, S.Y., Park, M.J., & Hong, S.J. (2020).TNF-α (rs1800629) polymorphism modifies the effect of sensitization to house dust mite in asthma and bronchial hyperresponsiveness in children. Exp. Mol. Pathol., 15, 104467. DOI:10.1016/j.yexmp.2020.104467. DOI: https://doi.org/10.1016/j.yexmp.2020.104467
Shi, Z.G., Sun, Y., Wang, K.S., Jia, J.D., Yang, J., & Li, Y.N. (2019). Effects of miR-26a/miR-146a/miR-31 on airway inflammation of asthma mice and asthma children. Eur. Rev. Med. Pharmacol. Sci., 23 (12), 5432-5440. DOI:10.26355/eurrev_201906_18212.
Kang, S.W., Kim, S.K., Han, Y.R., Hong, D., Chon, J., Chung, J.H., …, & Ban, J.Y. (2019). Promoter polymorphism (-308G/A) of tumor necrosis factor-alpha (TNF-α) gene and asthma risk: An updated meta-analysis. Genet. Test. Mol. Biomarkers., 23 (6), 363-372. DOI:10.1089/gtmb.2018.0238. DOI: https://doi.org/10.1089/gtmb.2018.0238
Nasser, M.Z., & Ezzat, D.A. (2018). Association of -308G/A polymorphism and serum level of TNF- α with bronchial asthma in children. Egypt J. Immunol., 25 (2), 117-124.
Krusche, J., Twardziok, M., Rehbach, K., Böck, A.,Tsang, M.S., Schröder, P.C., & Kumbrink, J. (2019). TNF-α-induced protein 3 is a key player in childhood asthma development and environment-mediated protection. J. Allergy Clin. Immunol., 144 (6), 1684-1696.e12. DOI:10.1016/j.jaci.2019.07.029. DOI: https://doi.org/10.1016/j.jaci.2019.07.029
Chen, C.L., Li, H., Xing, X.H., Guan, H.S., Zhang, J.H., & Zhao, J.W. (2015). Effect of TRPV1 gene mutation on bronchial asthma in children before and after treatment. Allergy Asthma Proc., 36 (2), e29-36. DOI:10.2500/aap.2015.36.3828.
Chen, C.-L., Li, H., Xing, X.-H., Guan, H.-S., Zhang, J.-H., & Zhao, J.-W. (2015). Effect of TRPV1 gene mutation on bronchial asthma in children before and after treatment. Allergy Asthma Proc., 36 (2), e29-36. DOI:10.2500/aap.2015.36.3828. DOI: https://doi.org/10.2500/aap.2015.36.3828
Ture, M., Yildiz, M., & Karkucak, M. (2015). Investigation of TNF-alpha gene (G308A) and GSTP1 gene (Ilel05Val) polymorphisms in turkish patients with retinopathy of prematurity. Turk. J. Med. Sci., 45, 164-169. DOI: https://doi.org/10.3906/sag-1307-94
Downloads
Published
How to Cite
Issue
Section
License
Authors who publish in this journal agree to the following terms:
1. The authors reserve the right to authorship of the work and pass the journal right of first publication of this work is licensed under a Creative Commons Attribution License, which allows others to freely distribute the work published with reference to the authors of the original work and the first publication of this magazine.
2. Authors are entitled to enter into a separate agreement on additional non-exclusive distribution of work in the form in which it was published in the magazine (eg work place in the electronic repository institution or publish monographs in part), provided that the reference to the first publication of this magazine.
3. Policy magazine allows and encourages authors placement on the Internet (eg, in storage facilities or on personal websites) manuscript of how to submit the manuscript to the editor and during his editorial processing, since it contributes to productive scientific discussion and positive impact on the efficiency and dynamics of citing published work (see. The Effect of Open Access).
